8A-PDHQ:修订间差异
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| StdInChIKey = QEXADSRMRUUCQJ-UHFFFAOYSA-N |
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'''{{PAGENAME}}'''(全称:'''8a-苯基十氢喹啉''',{{lang-en|8a-Phenyldecahydroquinoline}})是一种[[含氮化合物|含氮]][[有机化合物]],分子式[[C15H21N|C<sub>15</sub>H<sub>21</sub>N]],可作为[[NMDA受体拮抗剂]],1950年代开发<ref>US Patent 3035059</ref>。 |
'''{{PAGENAME}}'''(全称:'''8a-苯基十氢喹啉''',{{lang-en|8a-Phenyldecahydroquinoline}})是一种[[含氮化合物|含氮]][[有机化合物]],分子式[[C15H21N|C<sub>15</sub>H<sub>21</sub>N]],可作为[[NMDA受体拮抗剂]],1950年代由[[Parke-Davis]]开发<ref>US Patent 3035059</ref><ref>{{cite journal |last1=Chen |first1=C |last2=Kozikowski |first2=AP |last3=Wood |first3=PL |last4=Reynolds |first4=IJ |last5=Ball |first5=RG |last6=Pang |first6=YP |title=Synthesis and biological activity of 8a-phenyldecahydroquinolines as probes of PCP's binding conformation. A new PCP-like compound with increased in vivo potency. |journal=Journal of medicinal chemistry |date=1992-05-01 |volume=35 |issue=9 |pages=1634-8 |doi=10.1021/jm00087a020 |pmid=1315871}}</ref><ref>{{cite journal |last1=Elhallaoui |first1=M |last2=Laguerre |first2=M |last3=Carpy |first3=A |last4=Ouazzani |first4=FC |title=Molecular modeling of noncompetitive antagonists of the NMDA receptor: proposal of a pharmacophore and a description of the interaction mode. |journal=Journal of molecular modeling |date=2002-02 |volume=8 |issue=2 |pages=65-72 |doi=10.1007/s00894-001-0067-4 |pmid=12032600}}</ref>。 |
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==参考文献== |
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2024年2月24日 (六) 11:47的版本
识别信息 | |
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CAS号 | 131556-11-1 |
PubChem CID | |
ChemSpider | |
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CompTox Dashboard (EPA) | |
化学信息 | |
化学式 | C15H21N |
摩尔质量 | 215.34 g·mol−1 |
3D模型(JSmol) | |
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8A-PDHQ(全称:8a-苯基十氢喹啉,英語:8a-Phenyldecahydroquinoline)是一种含氮有机化合物,分子式C15H21N,可作为NMDA受体拮抗剂,1950年代由Parke-Davis开发[1][2][3]。
参考文献
- ^ US Patent 3035059
- ^ Chen, C; Kozikowski, AP; Wood, PL; Reynolds, IJ; Ball, RG; Pang, YP. Synthesis and biological activity of 8a-phenyldecahydroquinolines as probes of PCP's binding conformation. A new PCP-like compound with increased in vivo potency.. Journal of medicinal chemistry. 1992-05-01, 35 (9): 1634–8. PMID 1315871. doi:10.1021/jm00087a020.
- ^ Elhallaoui, M; Laguerre, M; Carpy, A; Ouazzani, FC. Molecular modeling of noncompetitive antagonists of the NMDA receptor: proposal of a pharmacophore and a description of the interaction mode.. Journal of molecular modeling. 2002-02, 8 (2): 65–72. PMID 12032600. doi:10.1007/s00894-001-0067-4.