S-甲基半胱氨酸
| S-甲基半胱氨酸 | |
|---|---|
| |
| 英文名 | S-Methylcysteine |
| 別名 | 3-甲硫基丙氨酸 |
| 識別 | |
| CAS號 | 7728-98-5  1187-84-4（L） 66255-16-1（S）
|
| PubChem | 24417 |
| ChemSpider | 22826 |
| SMILES |
|
| ChEBI | 45658 |
| DrugBank | 02216 |
| KEGG | C22040 |
| 性質 | |
| 化學式 | C4H9NO2S |
| 摩爾質量 | 135.18 g·mol−1 |
| 外觀 | 白色固體 |
| 熔點 | 248 °C（521 K） |
| 危險性 | |
GHS危險性符號
| |
| GHS提示詞 | 警告 |
| H-術語 | H302, H315, H319, H335 |
| P-術語 | P261, P264, P270, P271, P280, P301+312, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313 |
| 若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。 | |
S-甲基半胱氨酸是一種氨基酸，化學式為CH3SCH2CH(NH2)CO2H。它是半胱氨酸的巰基氫被甲基取代的衍生物。這種氨基酸廣泛存在於植物中，包括一些可食用蔬菜。[1]
生物合成[編輯]
這種氨基酸並非遺傳密碼，而由半胱氨酸在翻譯後的甲基化產生，甲基化的途徑之一就是通過半胱氨酸鋅的修復酶讓烷基化的DNA脫甲基。[2][3]
參考文獻[編輯]
- ^ Maw, George A. Biochemistry of S-Methyl-L-Cysteine and its Principal Derivatives. Sulfur Reports. 1982, 2: 1–26. doi:10.1080/01961778208082422.
- ^ Sors, Thomas G.; Ellis, Danielle R.; Na, Gun Nam; Lahner, Brett; Lee, Sangman; Leustek, Thomas; Pickering, Ingrid J.; Salt, David E. Analysis of sulfur and selenium assimilation in Astragalus plants with varying capacities to accumulate selenium. The Plant Journal. 2005, 42 (6): 785–797. PMID 15941393. doi:10.1111/j.1365-313X.2005.02413.x.
- ^ Clarke, Steven G. The ribosome: A hot spot for the identification of new types of protein methyltransferases. Journal of Biological Chemistry. 2018, 293 (27): 10438–10446. PMID 29743234. doi:10.1074/jbc.AW118.003235.
- ^ He, Haiyang; Lipowska, Malgorzata; Xu, Xiaolong; Taylor, Andrew T.; Carlone, Maria; Marzilli, Luigi G. Re(CO)3Complexes Synthesized via an Improved Preparation of Aqueousfac-[Re(CO)3(H2O)3]+as an Aid in Assessing 99m Tc Imaging Agents. Structural Characterization and Solution Behavior of Complexes with Thioether-Bearing Amino Acids as Tridentate Ligands. Inorganic Chemistry. 2005, 44 (15): 5437–5446. PMID 16022542. doi:10.1021/ic0501869.