细菌DNA结合蛋白
外观
Bac_DNA_binding | |||||||||
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anabaena hu-dna cocrystal structure (ahu6) | |||||||||
鑑定 | |||||||||
標誌 | Bac_DNA_binding | ||||||||
Pfam | PF00216(旧版) | ||||||||
InterPro | IPR000119 | ||||||||
PROSITE | PDOC00044 | ||||||||
SCOP | 1hue / SUPFAM | ||||||||
CDD | cd00591 | ||||||||
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细菌DNA结合蛋白(英語:Bacterial DNA binding protein)又被称为组蛋白类似蛋白(英語:histone-like proteins)[1][2],通常为碱性蛋白质,90个左右氨基酸残基,与特定DNA位点结合。
例子
[编辑]H-NS
[编辑]HU
[编辑]IHF
[编辑]比较
[编辑]DNA结合蛋白 | 大小 | 结构 | 结合位点 | 效应 |
---|---|---|---|---|
H-NS | 15.6 kDa | exists in dimers to physically prevent RNA polymerase from binding to promoter | binds to bent DNA, binds to P1 promoter in E. coli | regulation of gene expression |
HU | 10 kDa | α-helical core and two positively charged β-ribbon arms | binds non-specifically to dsDNA, binds to DsrA, a small non-coding RNA that regulates transcription | induces negative supercoiling into circular DNA |
IHF | 20 kDa | αβαβ hetrodimer | binds to specific sequences of DNA | creates kinks in DNA |
参考文献
[编辑]- ^ Drlica K, Rouviere-Yaniv J. Histonelike proteins of bacteria. Microbiol. Rev. September 1987, 51 (3): 301–19. PMC 373113 . PMID 3118156.
- ^ Pettijohn DE. Histone-like proteins and bacterial chromosome structure. J. Biol. Chem. September 1988, 263 (26): 12793–6. PMID 3047111.