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细菌DNA结合蛋白

维基百科,自由的百科全书
Bac_DNA_binding
anabaena hu-dna cocrystal structure (ahu6)
鑑定
標誌Bac_DNA_binding
PfamPF00216旧版
InterPro英语InterProIPR000119
PROSITE英语PROSITEPDOC00044
SCOP英语Structural Classification of Proteins1hue / SUPFAM
CDD英语Conserved Domain Databasecd00591

细菌DNA结合蛋白(英語:Bacterial DNA binding protein)又被称为组蛋白类似蛋白(英語:histone-like proteins[1][2],通常为碱性蛋白质,90个左右氨基酸残基,与特定DNA位点结合。

例子

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H-NS

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HU

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IHF

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比较

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Table 1. 三种细菌DNA结合蛋白的比较
DNA结合蛋白 大小 结构 结合位点 效应
H-NS 15.6 kDa exists in dimers to physically prevent RNA polymerase from binding to promoter binds to bent DNA, binds to P1 promoter in E. coli regulation of gene expression
HU 10 kDa α-helical core and two positively charged β-ribbon arms binds non-specifically to dsDNA, binds to DsrA, a small non-coding RNA that regulates transcription induces negative supercoiling into circular DNA
IHF 20 kDa αβαβ hetrodimer binds to specific sequences of DNAcreates kinks in DNA

参考文献

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  1. ^ Drlica K, Rouviere-Yaniv J. Histonelike proteins of bacteria. Microbiol. Rev. September 1987, 51 (3): 301–19. PMC 373113可免费查阅. PMID 3118156. 
  2. ^ Pettijohn DE. Histone-like proteins and bacterial chromosome structure. J. Biol. Chem. September 1988, 263 (26): 12793–6. PMID 3047111.