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細菌DNA結合蛋白

維基百科,自由的百科全書
Bac_DNA_binding
anabaena hu-dna cocrystal structure (ahu6)
鑑定
標誌Bac_DNA_binding
PfamPF00216舊版
InterPro英語InterProIPR000119
PROSITE英語PROSITEPDOC00044
SCOP英語Structural Classification of Proteins1hue / SUPFAM
CDD英語Conserved Domain Databasecd00591

細菌DNA結合蛋白(英語:Bacterial DNA binding protein)又被稱為組蛋白類似蛋白(英語:histone-like proteins[1][2],通常為鹼性蛋白質,90個左右氨基酸殘基,與特定DNA位點結合。

例子

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H-NS

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HU

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IHF

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比較

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Table 1. 三種細菌DNA結合蛋白的比較
DNA結合蛋白 大小 結構 結合位點 效應
H-NS 15.6 kDa exists in dimers to physically prevent RNA polymerase from binding to promoter binds to bent DNA, binds to P1 promoter in E. coli regulation of gene expression
HU 10 kDa α-helical core and two positively charged β-ribbon arms binds non-specifically to dsDNA, binds to DsrA, a small non-coding RNA that regulates transcription induces negative supercoiling into circular DNA
IHF 20 kDa αβαβ hetrodimer binds to specific sequences of DNAcreates kinks in DNA

參考文獻

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  1. ^ Drlica K, Rouviere-Yaniv J. Histonelike proteins of bacteria. Microbiol. Rev. September 1987, 51 (3): 301–19. PMC 373113可免費查閱. PMID 3118156. 
  2. ^ Pettijohn DE. Histone-like proteins and bacterial chromosome structure. J. Biol. Chem. September 1988, 263 (26): 12793–6. PMID 3047111.