Template:PBB/5551

穿孔素1
Perforin 1
穿孔素1; Perforin 1
	一個包含Plu-MACPF蛋白的MACPF域結構PDB 2QP2 MACPF域用青色/粉紅色表示；而?棱鏡域則是用橘色表示；兩個鈣原子則是用灰色表示
标识
代号	PRF1; FLH2; HPLH2; P1; PFN1; PFP
扩展标识	遗传学：170280 鼠基因：97551 同源基因：3698 ChEMBL: 5480 GeneCards: PRF1 Gene
基因本体论描述
分子功能	· calcium ion binding; · protein binding; · wide pore channel activity;
细胞成分	· extracellular region; · plasma membrane; · membrane; · integral component of membrane; · cytoplasmic membrane-bounded vesicle; · endosome lumen; · cytolytic granule;
生物过程	· defense response to tumor cell; · immune response to tumor cell; · apoptotic process; · cellular defense response; · cytolysis; · protein homooligomerization; · defense response to virus; · transmembrane transport;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	5551
Ensembl	ENSG00000180644
UniProt	P14222
mRNA序列	NM_001083116
蛋白序列	NP_001076585
基因位置	Chr 10:; 72.36 – 72.36 Mb
PubMed查询	[1]
	查; 论; 编;

参考资料

^ Rosado CJ, Buckle AM, Law RH, Butcher RE, Kan WT, Bird CH, Ung K, Browne KA, Baran K, Bashtannyk-Puhalovich TA, Faux NG, Wong W, Porter CJ, Pike RN, Ellisdon AM, Pearce MC, Bottomley SP, Emsley J, Smith AI, Rossjohn J, Hartland EL, Voskoboinik I, Trapani JA, Bird PI, Dunstone MA, Whisstock JC. A common fold mediates vertebrate defense and bacterial attack. Science. 2007, 317 (5844): 1548–51. PMID 17717151. doi:10.1126/science.1144706.