细菌DNA结合蛋白(英語:Bacterial DNA binding protein)又被称为组蛋白类似蛋白(英語:histone-like proteins)[1][2],通常为碱性蛋白质,90个左右氨基酸残基,与特定DNA位点结合。
Table 1. 三种细菌DNA结合蛋白的比较
DNA结合蛋白
|
大小
|
结构
|
结合位点
|
效应
|
H-NS
|
15.6 kDa
|
exists in dimers to physically prevent RNA polymerase from binding to promoter
|
binds to bent DNA, binds to P1 promoter in E. coli
|
regulation of gene expression
|
HU
|
10 kDa
|
α-helical core and two positively charged β-ribbon arms
|
binds non-specifically to dsDNA, binds to DsrA, a small non-coding RNA that regulates transcription
|
induces negative supercoiling into circular DNA
|
IHF
|
20 kDa
|
αβαβ hetrodimer
|
binds to specific sequences of DNA | creates kinks in DNA
|