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长双歧杆菌

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长双歧杆菌
长双歧杆菌的菌落
科学分类 编辑
域: 细菌域 Bacteria
门: 放线菌门 Actinomycetota
纲: 放线菌纲 Actinomycetes
目: 双歧杆菌目 Bifidobacteriales
科: 双歧杆菌科 Bifidobacteriaceae
属: 双歧杆菌属 Bifidobacterium
种:
长双歧杆菌 B. longum
二名法
Bifidobacterium longum
Reuter 1963 (Approved Lists 1980)[1]

长双歧杆菌学名Bifidobaterium longum)又称龙根菌,是双歧杆菌属的一种厌氧细菌[2][3],属革兰氏阳性菌。此菌可生长在人类消化道中并产生乳酸[4],是婴儿肠道中最早出现的菌种之一[2]。长双歧杆菌绝大多数情况不会致病,常被添加至食品中作为发酵用途[2][5]

分类

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2002年,16S 核糖体RNA序列分析的结果显示长双歧杆菌与同属另两种细菌婴儿双歧杆菌B. infantis)和猪双歧杆菌B. Suis)的序列相似度高达97%,应属同一物种[6][7]

生长环境

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婴儿肠道中有高达九成的细菌为包括本种在内的双歧杆菌属细菌[3],其比例会随婴儿长大成人而逐渐减少,成人的肠道中仅有3%的细菌为双歧杆菌,多种拟杆菌属真杆菌属的细菌取代该属细菌而成为优势物种[4]。有些长双歧杆菌的菌株对胃酸胆汁抗性很高,因此能在胃中存活,并进入肠道中[5][8]

长双歧杆菌具有线毛,可与肠上皮细胞英语Intestinal epithelium表面的糖蛋白结合,另外其细胞壁上的脂壁酸与带有电荷的多糖也能帮助此菌结合肠上皮细胞[2][9]

研究

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免疫系统调节

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使用长双歧杆菌已被证明可以缩短与普通感冒相关的症状的持续时间并最大程度地减轻其严重程度,其效果与神经氨酸酶抑制剂治疗流感的效果相似。

长双歧杆菌 BB536

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长双歧杆菌BB536于1969年在健康母乳喂养婴儿的肠道中发现[10]。它经常用于营养补充剂。在一些小型临床试验中,它已被证明可以帮助排便并缓解乳糖不耐症状。[11][12]

参考文献

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  1. ^ Parte, A.C. Bifidobacterium. LPSN. [2024-03-22]. (原始内容存档于2021-01-25). 
  2. ^ 2.0 2.1 2.2 2.3 Schell, M. A.; Karmirantzou, M.; Snel, B.; Vilanova, D.; Berger, B.; Pessi, G.; Zwahlen, M. -C.; Desiere, F.; Bork, P.; Delley, M.; Pridmore, R. D.; Arigoni, F. The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract. Proceedings of the National Academy of Sciences. 2002, 99 (22): 14422–14427. Bibcode:2002PNAS...9914422S. PMC 137899可免费查阅. PMID 12381787. doi:10.1073/pnas.212527599可免费查阅. 
  3. ^ 3.0 3.1 Garrido, D.; Ruiz-Moyano, S.; Jimenez-Espinoza, R.; Eom, H. J.; Block, D. E.; Mills, D. A. Utilization of galactooligosaccharides by Bifidobacterium longum subsp. Infantis isolates. Food Microbiology. 2013, 33 (2): 262–270. PMC 3593662可免费查阅. PMID 23200660. doi:10.1016/j.fm.2012.10.003. 
  4. ^ 4.0 4.1 Yuan, Jing; Zhu, Li; Liu, Xiankai; Li, Ting; Zhang, Ying; Ying, Tianyi; Wang, Bin; Wang, Junjun; Dong, Hua; Feng, Erling; Li, Qiang; Wang, Jie; Wang, Hongxia; Wei, Kaihua; Zhang, Xuemin; Huang, Cuifeng; Huang, Peitang; Huang, Liuyu; Zeng, Ming; Wang, Hengliang. A Proteome Reference Map and Proteomic Analysis of Bifidobacterium longum NCC2705. Molecular & Cellular Proteomics. June 2006, 5 (6): 1105–1118. PMID 16549425. doi:10.1074/mcp.M500410-MCP200可免费查阅. 
  5. ^ 5.0 5.1 Yazawa, Kazuyuki; Fujimori, Minoru; Amano, Jun; Kano, Yasunobu; Taniguchi, Shun'ichiro. Bifidobacterium longum as a delivery system for cancer gene therapy: Selective localization and growth in hypoxic tumors. Cancer Gene Therapy. February 2000, 7 (2): 269–274. PMID 10770636. S2CID 7375660. doi:10.1038/sj.cgt.7700122. 
  6. ^ Sakata, Shinji; Kitahara, Maki; Sakamoto, Mitsuo; Hayashi, Hidenori; Fukuyama, Masafumi; Benno, Yoshimi. Unification of Bifidobacterium infantis and Bifidobacterium suis as Bifidobacterium longum. International Journal of Systematic and Evolutionary Microbiology. 1 November 2002, 52 (6): 1945–1951. PMID 12508852. doi:10.1099/00207713-52-6-1945. 
  7. ^ Mattarelli, P.; Bonaparte, C.; Pot, B.; Biavati, B. Proposal to reclassify the three biotypes of Bifidobacterium longum as three subspecies: Bifidobacterium longum subsp. longum subsp. nov., Bifidobacterium longum subsp. infantis comb. nov. and Bifidobacterium longum subsp. suis comb. nov.. International Journal of Systematic and Evolutionary Microbiology. 1 April 2008, 58 (4): 767–772. PMID 18398167. doi:10.1099/ijs.0.65319-0可免费查阅. 
  8. ^ Xiao, J.Z.; Kondo, S.; Takahashi, N.; Miyaji, K.; Oshida, K.; Hiramatsu, A.; Iwatsuki, K.; Kokubo, S.; Hosono, A. Effects of Milk Products Fermented by Bifidobacterium longum on Blood Lipids in Rats and Healthy Adult Male Volunteers. Journal of Dairy Science. July 2003, 86 (7): 2452–2461. PMID 12906063. doi:10.3168/jds.S0022-0302(03)73839-9可免费查阅. 
  9. ^ Abbad Andaloussi, S.; Talbaoui, H.; Marczak, R.; Bonaly, R. Isolation and characterization of exocellular polysaccharides produced by Bifidobacterium longum. Applied Microbiology and Biotechnology. November 1995, 43 (6): 995–1000. PMID 8590666. S2CID 10837355. doi:10.1007/BF00166915. 
  10. ^ Minami, Miki; Tsuji, Shoji; Akagawa, Shohei; Akagawa, Yuko; Yoshimoto, Yuki; Kawakami, Hirosato; Kohno, Mamiko; Kaneko, Kazunari. Effect of a Bifidobacterium-Containing Acid-Resistant Microcapsule Formulation on Gut Microbiota: A Pilot Study. Nutrients. 2022-11-15, 14 (22) [2024-04-12]. ISSN 2072-6643. doi:10.3390/nu14224829. (原始内容存档于2024-03-27) (英语). 
  11. ^ Takeda, Tsutomu; Asaoka, Daisuke; Nojiri, Shuko; Yanagisawa, Naotake; Nishizaki, Yuji; Osada, Taro; Koido, Shigeo; Nagahara, Akihito; Katsumata, Noriko; Odamaki, Toshitaka; Xiao, Jin-Zhong. Usefulness of Bifidobacterium longum BB536 in Elderly Individuals With Chronic Constipation: A Randomized Controlled Trial. American Journal of Gastroenterology. 2023-03, 118 (3). ISSN 0002-9270. PMC 9973440可免费查阅. PMID 36216361. doi:10.14309/ajg.0000000000002028 (英语). 
  12. ^ Vitellio, Paola; Celano, Giuseppe; Bonfrate, Leonilde; Gobbetti, Marco; Portincasa, Piero; De Angelis, Maria. Effects of Bifidobacterium longum and Lactobacillus rhamnosus on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study. Nutrients. 2019-04-19, 11 (4) [2024-04-12]. ISSN 2072-6643. PMC 6520754可免费查阅. PMID 31010241. doi:10.3390/nu11040886. (原始内容存档于2024-04-13) (英语).