4-氟丁醇

4-氟丁醇
别名	4-氟丁-1-醇; 4-氟-1-丁醇; 4-氟正丁醇
识别
CAS号	372-93-0
PubChem	9755
ChemSpider	9372
SMILES	C(CCF)CO;
InChI	1S/C4H9FO/c5-3-1-2-4-6/h6H,1-4H2;
InChIKey	SHOBGSRUFRALBO-UHFFFAOYSA-N
性质
化学式	C4H9FO
摩尔质量	92.11 g·mol−1
沸点	129.3 °C（402 K）
溶解性（水）	8 g·L−1（25 °C）
危险性
	GHS危险性符号;
GHS提示词	警告
H-术语	H226, H315, H319, H335
P-术语	P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P302+352, P303+361+353, P304+340, P305+351+338
	致死量或浓度：
LD50（中位剂量）	0.9 mg·kg−1(mouse, injected IP or SC)
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

4-氟丁醇是一种有机化合物，为无色的可燃性液体，化学式为C₄H₉FO。它可由乙酸-4-羟基丁酯经二乙氨基三氟化硫氟化后，用氢化铝锂还原制得。^[2]1,4-丁二醇和四氟化硫的反应虽然也会生成4-氟丁醇，但是也会同时产生四氢呋喃和少量的亚硫酸丁二酯。^[3]它可以被马丁试剂氧化为4-氟丁醛。^[4]

它和2-氟乙醇一样，会因其代谢为氟乙酸盐而具有高毒性。^[5]^[6]

参考文献

^ Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (© 1994-2020 ACD/Labs). Retrieved from SciFinder. [2020-11-30].
^ Rebecca J. M. Goss, Hui Hong. A novel fluorinated erythromycin antibiotic. Chemical Communications. 2005, (31): 3983 [2020-11-30]. ISSN 1359-7345. doi:10.1039/b506635b （英语）.
^ Wang, Chia-Lin J. Sulfur tetrafluoride. e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001. 1-2.
^ Giovanni Tangherlini, Dmitrii V. Kalinin, Dirk Schepmann, Tao Che, Nadine Mykicki, Sonja Ständer, Karin Loser, Bernhard Wünsch. Development of Novel Quinoxaline-Based κ-Opioid Receptor Agonists for the Treatment of Neuroinflammation. Journal of Medicinal Chemistry. 2019-01-24, 62 (2): 893–907 [2020-11-30]. ISSN 0022-2623. doi:10.1021/acs.jmedchem.8b01609 （英语）.
^ Pattison F. Toxic Fluorine Compounds. Nature 1953; 172: 1139–1141.doi:10.1038/1721139a0
^ Pattison FML, Howell WC, McNamara AJ, Schneider JC, Walker JF. Toxic Fluorine Compounds. III.¹ ω-Fluoroalcohols. The Journal of Organic Chemistry 1956; 21(7): 739-747. doi:10.1021/jo01113a006

[1] Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (© 1994-2020 ACD/Labs). Retrieved from SciFinder. [2020-11-30].

[2] Rebecca J. M. Goss, Hui Hong. A novel fluorinated erythromycin antibiotic. Chemical Communications. 2005, (31): 3983 [2020-11-30]. ISSN 1359-7345. doi:10.1039/b506635b （英语）.

[3] Wang, Chia-Lin J. Sulfur tetrafluoride. e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001. 1-2.

[4] Giovanni Tangherlini, Dmitrii V. Kalinin, Dirk Schepmann, Tao Che, Nadine Mykicki, Sonja Ständer, Karin Loser, Bernhard Wünsch. Development of Novel Quinoxaline-Based κ-Opioid Receptor Agonists for the Treatment of Neuroinflammation. Journal of Medicinal Chemistry. 2019-01-24, 62 (2): 893–907 [2020-11-30]. ISSN 0022-2623. doi:10.1021/acs.jmedchem.8b01609 （英语）.

[5] Pattison F. Toxic Fluorine Compounds. Nature 1953; 172: 1139–1141.doi:10.1038/1721139a0

[6] Pattison FML, Howell WC, McNamara AJ, Schneider JC, Walker JF. Toxic Fluorine Compounds. III.¹ ω-Fluoroalcohols. The Journal of Organic Chemistry 1956; 21(7): 739-747. doi:10.1021/jo01113a006

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