4-氟丁醇

4-氟丁醇
別名	4-氟丁-1-醇; 4-氟-1-丁醇; 4-氟正丁醇
識別
CAS號	372-93-0
PubChem	9755
ChemSpider	9372
SMILES	C(CCF)CO;
InChI	1S/C4H9FO/c5-3-1-2-4-6/h6H,1-4H2;
InChIKey	SHOBGSRUFRALBO-UHFFFAOYSA-N
性質
化學式	C4H9FO
摩爾質量	92.11 g·mol−1
沸點	129.3 °C（402 K）
溶解性（水）	8 g·L−1（25 °C）
危險性
	GHS危險性符號;
GHS提示詞	警告
H-術語	H226, H315, H319, H335
P-術語	P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P302+352, P303+361+353, P304+340, P305+351+338
	致死量或濃度：
LD50（中位劑量）	0.9 mg·kg−1(mouse, injected IP or SC)
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

4-氟丁醇是一種有機化合物，為無色的可燃性液體，化學式為C₄H₉FO。它可由乙酸-4-羥基丁酯經二乙氨基三氟化硫氟化後，用氫化鋁鋰還原製得。^[2]1,4-丁二醇和四氟化硫的反應雖然也會生成4-氟丁醇，但是也會同時產生四氫呋喃和少量的亞硫酸丁二酯。^[3]它可以被馬丁試劑氧化為4-氟丁醛。^[4]

它和2-氟乙醇一樣，會因其代謝為氟乙酸鹽而具有高毒性。^[5]^[6]

參考文獻

^ Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (© 1994-2020 ACD/Labs). Retrieved from SciFinder. [2020-11-30].
^ Rebecca J. M. Goss, Hui Hong. A novel fluorinated erythromycin antibiotic. Chemical Communications. 2005, (31): 3983 [2020-11-30]. ISSN 1359-7345. doi:10.1039/b506635b （英語）.
^ Wang, Chia-Lin J. Sulfur tetrafluoride. e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001. 1-2.
^ Giovanni Tangherlini, Dmitrii V. Kalinin, Dirk Schepmann, Tao Che, Nadine Mykicki, Sonja Ständer, Karin Loser, Bernhard Wünsch. Development of Novel Quinoxaline-Based κ-Opioid Receptor Agonists for the Treatment of Neuroinflammation. Journal of Medicinal Chemistry. 2019-01-24, 62 (2): 893–907 [2020-11-30]. ISSN 0022-2623. doi:10.1021/acs.jmedchem.8b01609 （英語）.
^ Pattison F. Toxic Fluorine Compounds. Nature 1953; 172: 1139–1141.doi:10.1038/1721139a0
^ Pattison FML, Howell WC, McNamara AJ, Schneider JC, Walker JF. Toxic Fluorine Compounds. III.¹ ω-Fluoroalcohols. The Journal of Organic Chemistry 1956; 21(7): 739-747. doi:10.1021/jo01113a006

[1] Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (© 1994-2020 ACD/Labs). Retrieved from SciFinder. [2020-11-30].

[2] Rebecca J. M. Goss, Hui Hong. A novel fluorinated erythromycin antibiotic. Chemical Communications. 2005, (31): 3983 [2020-11-30]. ISSN 1359-7345. doi:10.1039/b506635b （英語）.

[3] Wang, Chia-Lin J. Sulfur tetrafluoride. e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001. 1-2.

[4] Giovanni Tangherlini, Dmitrii V. Kalinin, Dirk Schepmann, Tao Che, Nadine Mykicki, Sonja Ständer, Karin Loser, Bernhard Wünsch. Development of Novel Quinoxaline-Based κ-Opioid Receptor Agonists for the Treatment of Neuroinflammation. Journal of Medicinal Chemistry. 2019-01-24, 62 (2): 893–907 [2020-11-30]. ISSN 0022-2623. doi:10.1021/acs.jmedchem.8b01609 （英語）.

[5] Pattison F. Toxic Fluorine Compounds. Nature 1953; 172: 1139–1141.doi:10.1038/1721139a0

[6] Pattison FML, Howell WC, McNamara AJ, Schneider JC, Walker JF. Toxic Fluorine Compounds. III.¹ ω-Fluoroalcohols. The Journal of Organic Chemistry 1956; 21(7): 739-747. doi:10.1021/jo01113a006

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