洛曼妥珠單抗
外觀
單克隆抗體 | |
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種類 | ? |
目標 | RSPO3 |
臨床資料 | |
其他名稱 | OMP-131R10 |
ATC碼 |
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識別資訊 | |
CAS號 | 1684393-04-1 |
ChemSpider |
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UNII | |
KEGG | |
化學資訊 | |
化學式 | C6456H9954N1714O2048S46 |
摩爾質量 | 145,825.36 g·mol−1 |
洛曼妥珠單抗(INN:rosmantuzumab[1];開發代號:OMP-131R10)是一種靶向RSPO3的人源化單克隆抗體,設計用於治療癌症。[2][3][4]
參考資料
[編輯]- ^ World Health Organization. International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 115 (PDF). WHO Drug Information. 2016, 30 (2).
- ^ Katoh M. Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation (Review). Int. J. Mol. Med. August 2018, 42 (2): 713–725. PMC 6034925
. PMID 29786110. doi:10.3892/ijmm.2018.3689.
- ^ Katoh M. Canonical and non-canonical WNT signaling in cancer stem cells and their niches: Cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review). Int. J. Oncol. November 2017, 51 (5): 1357–1369. PMC 5642388
. PMID 29048660. doi:10.3892/ijo.2017.4129.
- ^ Katoh M, Katoh M. Molecular genetics and targeted therapy of WNT-related human diseases (Review). Int. J. Mol. Med. September 2017, 40 (3): 587–606. PMC 5547940
. PMID 28731148. doi:10.3892/ijmm.2017.3071.
- ^ Statement On A Nonproprietary Name Adopted By The USAN Council - Rosmantuzumab, American Medical Association.
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