克羅莫結構域

現有可用的蛋白結構：
Pfam	結構（舊版） / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum（英語：PDBsum）	結構概要
PDB	1ak5, 1b3o, 1jcn, 1jr1, 1lrt, 1me7, 1me8, 1me9, 1meh, 1mei, 1mew, 1nf7, 1nfb, 1o50, 1pbj, 1pvm, 1pvn, 1vr9, 1vrd, 1xkf, 1y5h, 1yav, 1zfj, 2cu0, 2d4z, 2ef7, 2j9l, 2nyc, 2nye, 2o16, 2oox, 2oux, 2qh1, 2rc3, 2rif, 2rih, 2v8q, 2v92, 2v9j, 2yvx, 2yzi, 2yzq, 3ddj

克羅莫結構域
	多梳克羅莫結構域的結構
鑑定
標誌	Chromodomain
Pfam	PF00385（舊版）
InterPro（英語：InterPro）	IPR000953
SMART（英語：Simple Modular Architecture Research Tool）	SM00298
PROSITE（英語：PROSITE）	PS50013
SCOP（英語：Structural Classification of Proteins）	1pfb / SUPFAM
CDD（英語：Conserved Domain Database）	cd00024
現有可用的蛋白結構：
Pfam	結構（舊版） / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum（英語：PDBsum）	結構概要
PDB	1ak5, 1b3o, 1jcn, 1jr1, 1lrt, 1me7, 1me8, 1me9, 1meh, 1mei, 1mew, 1nf7, 1nfb, 1o50, 1pbj, 1pvm, 1pvn, 1vr9, 1vrd, 1xkf, 1y5h, 1yav, 1zfj, 2cu0, 2d4z, 2ef7, 2j9l, 2nyc, 2nye, 2o16, 2oox, 2oux, 2qh1, 2rc3, 2rif, 2rih, 2v8q, 2v92, 2v9j, 2yvx, 2yzi, 2yzq, 3ddj

克羅莫結構域或染色質結構域（英語：Chromodomain，chromatin organization modifier^[2]）是一種由40～50個氨基酸殘基組成的蛋白質結構域，往往存在於那些與染色質重塑及操控有關的蛋白質里。此結構域不管在植物及動物之中都高度保守，且在許多基因組（如小鼠）中代表了較大數量的各種蛋白質。許多包含克羅莫結構域的基因有多種可變剪接亞型，有些亞型完全把克羅莫結構域當作內含子切除出去^[3]。在哺乳動物中，包含克羅莫結構域的蛋白質主要負責涉及到染色質重塑及形成異染色質區域這兩方面的基因調控^[4]。包含克羅莫結構域的蛋白質亦會結合到甲基化組蛋白上^[5]^[6]且存在於RNA誘導的轉錄沉默複合物中^[7]。

另見[編輯]

參考文獻[編輯]

^ Min J, Zhang Y, Xu RM. Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev. August 2003, 17 (15): 1823–8. PMC 196225 . PMID 12897052. doi:10.1101/gad.269603.
^ S Messmer, A Franke, R Paro. Analysis of the functional role of the Polycomb chromo domain in Drosophila melanogaster. Genes Dev. July 1992, 6 (7): 1241–1254. PMID 1628830. doi:10.1101/gad.6.7.1241.
^ Tajul-Arifin, K; Teasdale, R; Ravasi, T; Humel, DA; Group, RIKEN GER; Members, GSL; Mattick, JS. Identification and Analysis of Chromodomain-Containing Proteins Encoded in the Mouse Transcriptome. Genome Res. 2003, 13 (6B): 1416–1429. PMC 403676 . PMID 12819141. doi:10.1101/gr.1015703.
^ Jones, DO; Cowell, IG; Singh, PB. Mammalian chromodomain proteins: their role in genome organisation and expression. Bioessays. 2000, 22 (2): 124–37. PMID 10655032. doi:10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E.
^ Nielsen, PR; Nietlispach, D; Mott, HR; Callaghan, J; Bannister, A; Kouzarides, T; Murzin, AG; Murzina, NV; Laue, ED; et al. Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9. Nature. 2002, 416 (6876): 103–7. PMID 11882902. doi:10.1038/nature722.
^ Jacobs, SA; Khorasanizadeh, S. Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail. Science. 2002, 295 (5562): 2080–3. PMID 11859155. doi:10.1126/science.1069473.
^ Verdel, A; Jia, S; Gerber, S; Sugiyama, T; Gygi, S; Grewal, S; Moazed, D. RNAi-Mediated Targeting of Heterochromatin by the RITS Complex. Science. 2004, 303 (5658): 672–6. PMC 3244756 . PMID 14704433. doi:10.1126/science.1093686.

外部連結[編輯]

Chromatin Remodeling: Chromodomains （頁面存檔備份，存於互聯網檔案館） at cellsignal.com （頁面存檔備份，存於互聯網檔案館）

[pmid12897052-1] Min J, Zhang Y, Xu RM. Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev. August 2003, 17 (15): 1823–8. PMC 196225 . PMID 12897052. doi:10.1101/gad.269603.

[pmid1628830-2] S Messmer, A Franke, R Paro. Analysis of the functional role of the Polycomb chromo domain in Drosophila melanogaster. Genes Dev. July 1992, 6 (7): 1241–1254. PMID 1628830. doi:10.1101/gad.6.7.1241.

[Tajul-3] Tajul-Arifin, K; Teasdale, R; Ravasi, T; Humel, DA; Group, RIKEN GER; Members, GSL; Mattick, JS. Identification and Analysis of Chromodomain-Containing Proteins Encoded in the Mouse Transcriptome. Genome Res. 2003, 13 (6B): 1416–1429. PMC 403676 . PMID 12819141. doi:10.1101/gr.1015703.

[Jones-4] Jones, DO; Cowell, IG; Singh, PB. Mammalian chromodomain proteins: their role in genome organisation and expression. Bioessays. 2000, 22 (2): 124–37. PMID 10655032. doi:10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E.

[Nielsen-5] Nielsen, PR; Nietlispach, D; Mott, HR; Callaghan, J; Bannister, A; Kouzarides, T; Murzin, AG; Murzina, NV; Laue, ED; et al. Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9. Nature. 2002, 416 (6876): 103–7. PMID 11882902. doi:10.1038/nature722.

[Jacobs-6] Jacobs, SA; Khorasanizadeh, S. Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail. Science. 2002, 295 (5562): 2080–3. PMID 11859155. doi:10.1126/science.1069473.

[Verdel-7] Verdel, A; Jia, S; Gerber, S; Sugiyama, T; Gygi, S; Grewal, S; Moazed, D. RNAi-Mediated Targeting of Heterochromatin by the RITS Complex. Science. 2004, 303 (5658): 672–6. PMC 3244756 . PMID 14704433. doi:10.1126/science.1093686.

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