S-甲基半胱氨酸
| S-甲基半胱氨酸 | |
|---|---|
| |
| 英文名 | S-Methylcysteine |
| 别名 | 3-甲硫基丙氨酸 |
| 识别 | |
| CAS号 | 7728-98-5  1187-84-4（L） 66255-16-1（S）
|
| PubChem | 24417 |
| ChemSpider | 22826 |
| SMILES |
|
| ChEBI | 45658 |
| DrugBank | 02216 |
| KEGG | C22040 |
| 性质 | |
| 化学式 | C4H9NO2S |
| 摩尔质量 | 135.18 g·mol−1 |
| 外观 | 白色固体 |
| 熔点 | 248 °C（521 K） |
| 危险性 | |
GHS危险性符号
| |
| GHS提示词 | 警告 |
| H-术语 | H302, H315, H319, H335 |
| P-术语 | P261, P264, P270, P271, P280, P301+312, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313 |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
S-甲基半胱氨酸是一种氨基酸，化学式为CH3SCH2CH(NH2)CO2H。它是半胱氨酸的巯基氢被甲基取代的衍生物。这种氨基酸广泛存在于植物中，包括一些可食用蔬菜。[1]
生物合成
[编辑]这种氨基酸并非遗传密码，而由半胱氨酸在翻译后的甲基化产生，甲基化的途径之一就是通过半胱氨酸锌的修复酶让烷基化的DNA脱甲基。[2][3]
参考文献
[编辑]- ^ Maw, George A. Biochemistry of S-Methyl-L-Cysteine and its Principal Derivatives. Sulfur Reports. 1982, 2: 1–26. doi:10.1080/01961778208082422.
- ^ Sors, Thomas G.; Ellis, Danielle R.; Na, Gun Nam; Lahner, Brett; Lee, Sangman; Leustek, Thomas; Pickering, Ingrid J.; Salt, David E. Analysis of sulfur and selenium assimilation in Astragalus plants with varying capacities to accumulate selenium. The Plant Journal. 2005, 42 (6): 785–797. PMID 15941393. doi:10.1111/j.1365-313X.2005.02413.x.
- ^ Clarke, Steven G. The ribosome: A hot spot for the identification of new types of protein methyltransferases. Journal of Biological Chemistry. 2018, 293 (27): 10438–10446. PMID 29743234. doi:10.1074/jbc.AW118.003235.
- ^ He, Haiyang; Lipowska, Malgorzata; Xu, Xiaolong; Taylor, Andrew T.; Carlone, Maria; Marzilli, Luigi G. Re(CO)3Complexes Synthesized via an Improved Preparation of Aqueousfac-[Re(CO)3(H2O)3]+as an Aid in Assessing 99m Tc Imaging Agents. Structural Characterization and Solution Behavior of Complexes with Thioether-Bearing Amino Acids as Tridentate Ligands. Inorganic Chemistry. 2005, 44 (15): 5437–5446. PMID 16022542. doi:10.1021/ic0501869.