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鄰苯二甲酸二乙酯

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鄰苯二甲酸二乙酯[1]
Skeletal formula of diethyl phthalate
Ball-and-stick model of the diethyl phthalate molecule
IUPAC名
Diethyl benzene-1,2-dicarboxylate
1,2-苯二甲酸二乙酯
別名 Diethyl phthalate
識別
CAS號 84-66-2  checkY
PubChem 6781
ChemSpider 13837303
SMILES
 
  • CCOC(=O)c1ccccc1C(=O)OCC
InChI
 
  • 1/C12H14O4/c1-3-15-11(13)9-7-5-6-8-10(9)12(14)16-4-2/h5-8H,3-4H2,1-2H3
InChIKey FLKPEMZONWLCSK-UHFFFAOYAV
ChEBI 34698
KEGG D03804
性質
化學式 C12H14O4
莫耳質量 222.24 g/mol g·mol⁻¹
外觀 colourless, oily liquid
密度 1.12 g/cm3 at 20 °C
熔點 -4 °C(269 K)
沸點 295 °C(568 K)
溶解性 1080 mg/L at 25 °C
log P 2.42
蒸氣壓 0.002 mmHg (25°C)[2]
磁化率 -127.5·10−6 cm3/mol
危險性
NFPA 704
1
1
0
 
爆炸極限 0.7%-?[2]
PEL none[2]
致死量或濃度:
LD50中位劑量
8600 mg/kg (Rat)
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。

鄰苯二甲酸二乙酯(英語:Diethyl phthalate,縮寫DEP)是一種鄰苯二甲酸乙醇形成的,室溫下為無色澄清液體,密度略大於水,燃燒時會產生有毒氣體[3]

由於鄰苯二甲酸二乙酯可溶於大部分有機溶劑,因此常用於化妝品和香水[4] ,其他工業用途包括增塑劑、洗滌劑和噴霧劑[5]。由於皮膚經常暴露於鄰苯二甲酸二乙酯,它的毒性問題非常重要。幾個研究表明鄰苯二甲酸二乙酯會造成神經系統損傷和男性與女性的生殖系統問題[6][7][8]

參考文獻

[編輯]
  1. ^ Chemical Information Profile for Diethyl Phthalate (PDF). Integrated Laboratory Systems, Inc. [3 March 2009]. (原始內容 (PDF)存檔於1 February 2009). 
  2. ^ 2.0 2.1 2.2 NIOSH Pocket Guide to Chemical Hazards. #0213. NIOSH. 
  3. ^ ICSC:NENG0258 (International Chemical Safety Card for 1,2-Benzenedicarboxylic acid diethyl ester). [2020-02-01]. (原始內容存檔於2017-10-25). 
  4. ^ Api, A.M. Toxicological profile of diethyl phthalate: a vehicle for fragrance and cosmetic ingredients. Food and Chemical Toxicology. 2001, 39 (2): 97–108. doi:10.1016/S0278-6915(00)00124-1. 
  5. ^ Ghorpade, N.; Mehta, V.; Khare, M. Toxicity Study of Diethyl Phthalate on Freshwater Fish Cirrhina mrigala. Ecotoxicology and Environmental Safety. 2002, 53 (2): 255–258. doi:10.1006/eesa.2002.2212. 
  6. ^ Miodovnik, A. Endocrine disruptors and childhood social impairment. Neurotoxicology. March 2011, 32 (2): 261–267. PMC 3057338可免費查閱. PMID 21182865. doi:10.1016/j.neuro.2010.12.009. 
  7. ^ Ivelisse Colón et al. Identification of Phthalate Esters in the Serum of Young Puerto Rican Girls with Premature Breast Development. Environmental Health Perspectives. 2000, 108 (9): 895–900. PMC 2556932可免費查閱. PMID 11017896. doi:10.1289/ehp.00108895. 
  8. ^ Shanna H. Swan. Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans. Environmental Research. 2008, 108 (2): 177–184. Bibcode:2008ER....108..177S. PMC 2775531可免費查閱. PMID 18949837. doi:10.1016/j.envres.2008.08.007.