SIB-1757

**SIB-1757**
识别信息
	IUPAC命名法 6-methyl-2-(phenylazo)-3-pyridinol; ;
CAS号	31993-01-8
PubChem CID	6849066;
ChemSpider	10654582;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID00425754 ;
ECHA InfoCard	100.164.315
化学信息
化学式	C12H11N3O
摩尔质量	213.24 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES Oc1ccc(C)nc1\N=N\c2ccccc2;
	InChI InChI=1S/C12H11N3O/c1-9-7-8-11(16)12(13-9)15-14-10-5-3-2-4-6-10/h2-8,16H,1H3/b15-14+; Key:LOCPVWIREQIGNQ-CCEZHUSRSA-N;

SIB-1757是一种有机化合物，分子式C₁₂H₁₁N₃O，带有偶氮基团，可作为代谢型谷氨酸受体亚型mGluR₅的受体拮抗剂^[1]，在动物实验中存在抗痛觉过敏作用^[2]。

参考文献[编辑]

^ Varney MA, Cosford ND, Jachec C, Rao SP, Sacaan A, Lin FF, Bleicher L, Santori EM, Flor PJ, Allgeier H, Gasparini F, Kuhn R, Hess SD, Veliçelebi G, Johnson EC. SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5. The Journal of Pharmacology and Experimental Therapeutics. July 1999, 290 (1): 170–81. PMID 10381773.
^ Dogrul A, Ossipov MH, Lai J, Malan TP, Porreca F. Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR(5)) antagonist, in experimental neuropathic pain in rats. Neuroscience Letters. October 2000, 292 (2): 115–8. PMID 10998562. doi:10.1016/S0304-3940(00)01458-0.