印戒细胞

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高倍率显微镜下转移性乳腺印戒细胞癌的印戒细胞(苏木精-伊红染色
印戒细胞癌的印戒细胞(PAS染色
印戒细胞癌的印戒细胞(苏木精-伊红染色

印戒细胞Signet ring cell)在组织学上是一种恶性的细胞类型,主要见于癌症组织。

印戒细胞最常见于胃癌[1],但它也可出现在人体的任何组织,包括前列腺[2]膀胱胆囊[3]乳腺结肠[4]卵巢间质和睾丸[5]等。

外观[编辑]

印戒细胞这个名称来源于细胞的外观。印戒细胞含有大量的粘蛋白,从而将细胞核挤向了细胞的一侧外围,类似图章戒指,故得名。

诊断意义[编辑]

印戒细胞数量显著增加,往往预示患者的预后较差[6][7]

分类[编辑]

印戒细胞癌可以通过免疫組織化學进行分类[8]

参考资料[编辑]

  1. ^ Cancer Research UK. Signet Ring Cancer. cancerhelp.org.uk. URL: http://www.cancerhelp.org.uk/help/default.asp?page=7581. Accessed on: November 2, 2007.
  2. ^ Leong FJ, Leong AS, Swift J. Signet-ring carcinoma of the prostate. Pathol. Res. Pract. 1996, 192 (12): 1232–8; discussion 1239–41. PMID 9182294. 
  3. ^ Jain V, Gupta K, Kudva R, Rodrigues GS. A case of ovarian metastasis of gallbladder carcinoma simulating primary ovarian neoplasm: diagnostic pitfalls and review of literature. Int. J. Gynecol. Cancer. 2006,. 16 Suppl 1: 319–21. doi:10.1111/j.1525-1438.2006.00335.x. PMID 16515613. 
  4. ^ Makino T, Tsujinaka T, Mishima H, et al.. Primary signet-ring cell carcinoma of the colon and rectum: report of eight cases and review of 154 Japanese cases. Hepatogastroenterology. 2006, 53 (72): 845–9. PMID 17153438. 
  5. ^ Michal M, Hes O, Kazakov DV. Primary signet-ring stromal tumor of the testis. Virchows Arch. 2005, 447 (1): 107–10. doi:10.1007/s00428-005-1218-2. PMID 15909171. 
  6. ^ Lee WS, Chun HK, Lee WY, et al.. Treatment outcomes in patients with signet ring cell carcinoma of the colorectum. Am. J. Surg. 2007, 194 (3): 294–8. doi:10.1016/j.amjsurg.2006.12.041. PMID 17693269. 
  7. ^ Cabebe EC, Mehta VK, Fisher G. Gastric Cancer. eMedicine.com. URL: http://www.emedicine.com/med/topic845.htm. Accessed on: November 8, 2007.
  8. ^ Tian MM, Zhao AL, Li ZW, Li JY. Phenotypic classification of gastric signet ring cell carcinoma and its relationship with clinicopathologic parameters and prognosis. World J. Gastroenterol. 2007, 13 (23): 3189–98. PMID 17589897. 

外部链接[编辑]