四硝酸二氯六氨二(1,6-己二胺)合三铂

**四硝酸二氯六氨二(1,6-己二胺)合三铂**
临床资料
ATC码	未分配;
识别信息
CAS号	172903-00-3
UNII	HAJ1000ARC;
ChEBI	CHEBI:85611 ;
化学信息
化学式	C12H50Cl2N14O12Pt3
摩尔质量	1,238.77 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES [O-][N+]([O-])=O.[O-][N+]([O-])=O.Cl[Pt-2]([NH3+])([NH3+])[NH2+]CCCCCC[NH2+][Pt-2]([NH3+])([NH3+])[NH2+]CCCCCC[NH2+][Pt-2]([NH3+])([NH3+])Cl.[O-][N+]([O-])=O.[O-][N+]([O-])=O;

四硝酸二氯六氨二(1,6-己二胺)合三铂是一种配位化合物，化学式为[ClPt(NH₃)₂]₂μ-{trans-Pt(NH₃)₂[H₂N(CH₂)₆NH₂]₂}(NO₃)₄，有专利报道了它的合成。^[1]它具有抗癌活性，在对三种卵巢瘤和四种黑色素瘤的研究中发现它的IC₅₀比顺铂至少低20倍。^[2]

参考文献

^ Valsecchi, Mariella; Conti, Marco; Del Greco, Luisa; Bugatti, Carlo; Menta, Ernesto; Giuliani, Ferdinando C.; Manzotti, Carla; Spinelli, Silvano; Farrell, Nicholas. Trinuclear cationic platinum complexes having antitumor activity and pharmaceutical compositions containing them. 1995. WO9526968.
^ Carla Manzotti; Graziella Pratesi; Ernesto Menta; Roberto Di Domenico; Ennio Cavalletti; Heinz H. Fiebig; Lloyd R. Kelland; Nicholas Farrell; Donatella Polizzi; Rosanna Supino; Gabriella Pezzoni; Franco Zunino. BBR 3464: A Novel Triplatinum Complex, Exhibiting a Preclinical Profile of Antitumor Efficacy Different from Cisplatin. Clin Cancer Res (2000) 6 (7): 2626–2634.

延伸阅读

Michael E. Oehlsen; Yun Qu; Nicholas Farrell. Reaction of Polynuclear Platinum Antitumor Compounds with Reduced Glutathione Studied by Multinuclear (1H, 1H−15N Gradient Heteronuclear Single-Quantum Coherence, and 195Pt) NMR Spectroscopy. Inorg. Chem. 2003, 42, 18, 5498–5506. doi:10.1021/ic030045b.

[1] Valsecchi, Mariella; Conti, Marco; Del Greco, Luisa; Bugatti, Carlo; Menta, Ernesto; Giuliani, Ferdinando C.; Manzotti, Carla; Spinelli, Silvano; Farrell, Nicholas. Trinuclear cationic platinum complexes having antitumor activity and pharmaceutical compositions containing them. 1995. WO9526968.

[2] Carla Manzotti; Graziella Pratesi; Ernesto Menta; Roberto Di Domenico; Ennio Cavalletti; Heinz H. Fiebig; Lloyd R. Kelland; Nicholas Farrell; Donatella Polizzi; Rosanna Supino; Gabriella Pezzoni; Franco Zunino. BBR 3464: A Novel Triplatinum Complex, Exhibiting a Preclinical Profile of Antitumor Efficacy Different from Cisplatin. Clin Cancer Res (2000) 6 (7): 2626–2634.

[1]

[2]