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N-乙酰转移酶2

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N-乙酰转移酶2
(芳香胺N-乙酰转移酶)
N-acetyltransferase 2 (arylamine N-acetyltransferase)
PDB rendering based on 2pfr.
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 NAT2; AAC2; NAT-2; PNAT
扩展标识 遗传学612182 鼠基因97279 同源基因115468 ChEMBL: 2194 GeneCards: NAT2 Gene
EC编号 2.3.1.5
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 10 17960
Ensembl ENSG00000156006 ENSMUSG00000025588
UniProt P11245 P50294
mRNA序列 NM_000015 NM_008673
蛋白序列 NP_000006 NP_032699
基因位置 Chr 8:
18.25 – 18.26 Mb
Chr 8:
67.49 – 67.49 Mb
PubMed查询 [1] [2]

N-乙酰转移酶2(英语:N-acetyltransferase 2,又称为芳香胺N-乙酰转移酶(arylamine N-acetyltransferase),缩写为NAT2), 是一个由人类基因 NAT2编码的[1]

功能

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NAT2是N-乙酰基转移酶的一种,另一种芳香胺N-乙酰转移酶:N-乙酰转移酶1(NAT1)的基因也在八号染色体上,位于NAT2基因附近[2]

参考文献

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  1. ^ Vatsis KP, Weber WW, Bell DA, Dupret JM, Evans DA, Grant DM, Hein DW, Lin HJ, Meyer UA, Relling MV. Nomenclature for N-acetyltransferases. Pharmacogenetics. February 1995, 5 (1): 1–17. PMID 7773298. doi:10.1097/00008571-199502000-00001. 
  2. ^ Entrez Gene: NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase). (原始内容存档于2019-10-18). 

延伸阅读

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  • Vatsis KP, Weber WW, Bell DA; et al. Nomenclature for N-acetyltransferases.. Pharmacogenetics. 1995, 5 (1): 1–17. PMID 7773298. doi:10.1097/00008571-199502000-00001. 
  • Windmill KF, McKinnon RA, Zhu X; et al. The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies.. Mutat. Res. 1997, 376 (1-2): 153–60. PMID 9202751. doi:10.1016/S0027-5107(97)00038-9. 
  • Lan Q, Rothman N, Chow WH; et al. No apparent association between NAT1 and NAT2 genotypes and risk of stomach cancer.. Cancer Epidemiol. Biomarkers Prev. 2003, 12 (4): 384–6. PMID 12692115. 
  • Ochs-Balcom HM, Wiesner G, Elston RC. A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer.. Am. J. Epidemiol. 2007, 166 (3): 246–54. PMID 17535831. doi:10.1093/aje/kwm066. 
  • Sanderson S, Salanti G, Higgins J. Joint effects of the N-acetyltransferase 1 and 2 (NAT1 and NAT2) genes and smoking on bladder carcinogenesis: a literature-based systematic HuGE review and evidence synthesis.. Am. J. Epidemiol. 2007, 166 (7): 741–51. PMID 17675654. doi:10.1093/aje/kwm167. 

外部链接

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