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Spo11

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维基百科,自由的百科全书
Spo11
识别号
别名SPO11;, CT35, SPATA43, TOPVIA, initiator of meiotic double stranded breaks, SPO11 initiator of meiotic double stranded breaks, Meiotic recombination, Spo11, Meiotic_Spo11, IPR013048, Spo11, TOPOVIA
外部IDOMIM605114 MGI1349669 HomoloGene6059 GeneCardsSPO11
基因位置(人类
20号染色体
染色体20号染色体[1]
20号染色体
Spo11的基因位置
Spo11的基因位置
基因座20q13.31起始57,329,803 bp[1]
终止57,343,994 bp[1]
直系同源
物种人类小鼠
Entrez
Ensembl
UniProt
mRNA​序列

​NM_012444
​NM_198265

NM_001083959
​NM_001083960
​NM_012046
​NM_001305434

蛋白序列

NP_036576
​NP_937998

NP_001077428
​NP_001077429
​NP_001292363
​NP_036176

基因位置​(UCSC)Chr 20: 57.33 – 57.34 MbChr 2: 172.82 – 172.84 Mb
PubMed​查找[3][4]
维基数据
查看/编辑人类查看/编辑小鼠

Spo11是人类基因spo11 编码的蛋白质,在真核生物中广泛存在,与古菌基因TopVIA为直系同源体,负责减数第一次分裂前期遗传重组中DNA的双链断裂的形成[5][6]

参考文献

[编辑]
  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000054796 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000005883 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Vrielynck N, Chambon A, Vezon D, Pereira L, Chelysheva L, De Muyt A, et al. A DNA topoisomerase VI-like complex initiates meiotic recombination. Science. February 2016, 351 (6276): 939–43 [2020-08-29]. Bibcode:2016Sci...351..939V. PMID 26917763. S2CID 206643600. doi:10.1126/science.aad5196. (原始内容存档于2020-07-11). 
  6. ^ Robert T, Nore A, Brun C, Maffre C, Crimi B, Bourbon HM, de Massy B. The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation. Science. February 2016, 351 (6276): 943–9 [2020-08-29]. Bibcode:2016Sci...351..943R. PMID 26917764. S2CID 9445593. doi:10.1126/science.aad5309. (原始内容存档于2020-07-11).