蟾毒灵
外观
蟾毒灵 | |
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IUPAC名 (3β,5β)-3,14-Dihydroxybufa-20,22-dienolide | |
识别 | |
CAS号 | 465-21-4 |
PubChem | 9547215 |
ChemSpider | 7826155 |
SMILES |
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ChEBI | 517248 |
性质 | |
化学式 | C24H34O4 |
摩尔质量 | 386.52 g·mol−1 |
危险性 | |
GHS危险性符号![]() | |
GHS提示词 | Danger |
H-术语 | H300 |
P-术语 | P264, P270, P301+310, P321, P330, P405, P501 |
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。 |
蟾毒灵(英语:bufalin)又称蟾蜍灵,是一种具有强心作用的甾体蟾蜍毒素,是中药蟾酥中的有效成分之一。[1][2]
应用
[编辑]蟾毒灵在体外具有抗肿瘤的功效,如肝癌[3]和肺癌。[4] 但由于其所具有的心脏毒性,实际使用起来不如其他的蟾二烯羟酸内酯。[5]
参考资料
[编辑]- ^ "Datasheet: Bufotalin sc-sc-200136" Santa Cruz Biotechnology, Inc.https://datasheets.scbt.com/sc-200136.pdf (页面存档备份,存于互联网档案馆)
- ^ Okada, Masahiro; Suga, Toshiro; et al. Pharmacology of the priniciples isolated from Senso (Ch'an Su) the dried venom of the Chinese toad (IV) (PDF). Asian Medical Journal. April 1960, 3 (4): 155–160 [2021-04-10]. (原始内容存档 (PDF)于2017-04-27).
- ^ Zhang ZJ. Bufalin attenuates the stage and metastatic potential of hepatocellular carcinoma in nude mice.. J Transl Med. Feb 2014, 12: 57. PMC 4015709
. PMID 24581171. doi:10.1186/1479-5876-12-57.
- ^ Wu SH. Bufalin induces cell death in human lung cancer cells through disruption of DNA damage response pathways. Am J Chin Med. 2014, 42 (3): 729–42. PMID 24871662. doi:10.1142/S0192415X14500475.
- ^ Ma H. The novel antidote Bezoar Bovis prevents the cardiotoxicity of Toad (Bufo bufo gargarizans Canto) Venom in mice. Exp Toxicol Pathol. Jul 2012, 64 (5): 417–23. PMID 21084181. doi:10.1016/j.etp.2010.10.007.
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