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BW-723C86

维基百科,自由的百科全书
BW-723C86
识别信息
  • 1-[5-(2-Thienylmethoxy)-1H-indol-3-yl]-2-propanamine
CAS号160521-74-4  checkY
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C16H18N2OS
摩尔质量286.39 g·mol−1
3D模型(JSmol英语JSmol
  • c2c1c([nH]cc1CC(C)N)ccc2OCc3cccs3
  • InChI=1S/C16H18N2OS/c1-11(17)7-12-9-18-16-5-4-13(8-15(12)16)19-10-14-3-2-6-20-14/h2-6,8-9,11,18H,7,10,17H2,1H3 ☒N
  • Key:ALFGDCNSEBJYSP-UHFFFAOYSA-N ☒N

BW-723C86是一种人工合成的带有噻吩官能团色胺衍生物,分子式C16H18N2OS,可作为5-HT2B受体激动剂[1],在动物实验中显示出有抗焦虑药作用[2]并对在一些其它组织中5-HT2B受体的功能进行了研究。

参考文献

[编辑]
  1. ^ Kennett GA, Bright F, Trail B, Baxter GS, Blackburn TP. Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety. British Journal of Pharmacology. April 1996, 117 (7): 1443–8. PMC 1909458可免费查阅. PMID 8730737. doi:10.1111/j.1476-5381.1996.tb15304.x. 
  2. ^ Kennett GA, Trail B, Bright F. Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated. Neuropharmacology. December 1998, 37 (12): 1603–10. PMID 9886683. S2CID 7310462. doi:10.1016/S0028-3908(98)00115-4.