HLA-B

HLA-B
已知的结构 PDB 人类UniProt搜索: PDBe RCSB PDBID列表 3VCL、​4U1H、​4U1K、​5EO1、​5EO0,%%s1AGB、​1AGC、​1AGD、​1AGE、​1AGF、​1M05、​1MI5、​3FFC、​3SJV、​3SKM、​3SKO、​3SPV、​3X13、​3X14、​4QRP、​4QRQ、​4QRS、​4QRT、​4QRU,%%s4O2C、​4O2E、​4O2F,%%s3LN4、​3LN5,%%s4U1J、​4U1M、​4U1N,%%s4U1I、​4U1L、​4U1S,%%s1HSA、​1JGD、​1JGE、​1K5N、​1OF2、​1OGT、​1UXS、​1UXW、​1W0V、​1W0W、​2A83、​2BSR、​2BSS、​2BST、​3B3I、​3B6S、​3BP4、​3BP7、​3CZF、​3D18、​3DTX、​3HCV、​3LV3、​4G8G、​4G8I、​4G9D、​4G9F、​5DEF、​5DEG,%%s1A1N、​1A9B、​1A9E、​1CG9、​1XH3、​1ZHK、​1ZHL、​1ZSD、​2AK4、​2AXF、​2AXG、​2H6P、​2NW3、​2NX5、​3BW9、​3BWA、​3KWW、​3KXF、​3LKN、​3LKO、​3LKP、​3LKQ、​3LKR、​3LKS、​3MV7、​3MV8、​3MV9、​3VFS、​3VFT、​3VFU、​3VFV、​3VFW、​4LNR、​4PR5、​4PRN、​4QRR,%%s1A1M、​1A1O,%%s2BVO、​2BVP、​2BVQ、​2HJL、​2RFX、​2YPK、​2YPL、​3UPR、​3VH8、​3VRI、​3VRJ、​3WUW、​3X11、​3X12、​5B39、​5B38,%%s4JQV、​4XXC,%%s1XR8、​1XR9、​3C9N,%%s4LCY,%%s1M6O、​1N2R、​1SYV、​3DX6、​3DX7、​3DX8、​3DXA、​3KPL、​3KPM、​3KPN、​3KPO、​3KPP、​3KPQ、​3KPR、​3KPS、​3L3D、​3L3G、​3L3I、​3L3J、​4JQX,%%s1E27、​1E28、​4MJI,%%s3W39
识别号
别名	HLA-B；, AS, SPDA1, Bw-47, Bw-50, major histocompatibility complex, class I, B, B-4901, B-5001, HEL-S-83, HLA-B*45ZJ, HLA-B-3506, HLA-B-3905, HLA-B-5502, HLA-B-5602, HLA-B15, HLA-B39, HLA-B49, HLA-B50, HLA-B55, HLA-B59, HLA-B61, HLA-Cw, HLA-DRB1
外部ID	HomoloGene：134029 GeneCards：HLA-B
相关疾病
人类免疫缺陷病毒传染性疾病
基因位置（人类） 染色体 6号染色体 基因座 6p21.33 起始 31,353,872 bp 终止 31,367,067 bp
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • signaling receptor binding • peptide antigen binding 细胞组分 • integral component of membrane • phagocytic vesicle membrane • 高尔基体 • early endosome membrane • 膜 • Golgi membrane • 细胞膜 • integral component of plasma membrane • cell surface • 内质网 • MHC class I protein complex • ER to Golgi transport vesicle membrane • integral component of lumenal side of endoplasmic reticulum membrane • 外排体 • secretory granule membrane • recycling endosome membrane 生物学过程 • antigen processing and presentation • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • regulation of interleukin-12 production • interferon-gamma-mediated signaling pathway • immune system process • antigen processing and presentation of peptide antigen via MHC class I • regulation of dendritic cell differentiation • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent • protection from natural killer cell mediated cytotoxicity • type I interferon signaling pathway • 免疫反应 • regulation of immune response • regulation of T cell anergy • viral process • regulation of interleukin-6 production • neutrophil degranulation Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	3106	无数据
Ensembl	ENSG00000228964 ​ENSG00000234745 ​ENSG00000206450 ​ENSG00000224608 ​ENSG00000223532 ​ENSG00000232126	无数据
UniProt	P01889	无数据
mRNA​序列	NM_005514	无数据
蛋白序列	NP_005505	无数据
基因位置​（UCSC）	Chr 6: 31.35 – 31.37 Mb	无数据
PubMed​查找		无数据
维基数据
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HLA-B是人类白细胞抗原（HLA）的一个基因座，位于6号染色体上。

延伸阅读

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• Letvin NL, Walker BD. Immunopathogenesis and immunotherapy in AIDS virus infections. Nat Med. 2003, 9 (7): 861–6. PMID 12835706. doi:10.1038/nm0703-861. 
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• Sheehan NJ. The ramifications of HLA-B27. J R Soc Med. 2004, 97 (1): 10–4. PMC 1079257 . PMID 14702356. doi:10.1258/jrsm.97.1.10. 
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This article incorporates public domain text from The U.S. National Library of Medicine（页面存档备份，存于互联网档案馆）

外部链接

• OMIM 142830
• EntrezGene 3106
• Template:GeneCard
• Nomenclature for factors of the HLA system