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NPHS2

維基百科,自由的百科全書
NPHS2,特發性,類固醇耐藥性(足細胞)
標識
代號 NPHS2; PDCN; SRN1
擴展標識 遺傳學604766 鼠基因2157018 同源基因22826 GeneCards: NPHS2 Gene
RNA表達模式
更多表達數據
直系同源體
物種 人類 小鼠
Entrez 7827 170484
Ensembl ENSG00000116218 ENSMUSG00000026602
UniProt Q9NP85 Q91X05
mRNA序列 NM_001297575 NM_130456
蛋白序列 NP_001284504 NP_569723
基因位置 Chr 1:
179.52 – 179.55 Mb
Chr 1:
156.31 – 156.33 Mb
PubMed查詢 [1] [2]

足蛋白(Podocin、NPHS2)是在人體內由NPHS2(Nephrosis 2)基因編碼的蛋白質[1][2][3]

交互作用

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NPHS2已經顯示出與腎病蛋白(Nephrin)[4]CD2AP[4]有所交互作用

參見

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註釋

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  1. ^ Fuchshuber A, Jean G, Gribouval O, Gubler MC, Broyer M, Beckmann JS, Niaudet P, Antignac C. Mapping a gene (SRN1) to chromosome 1q25-q31 in idiopathic nephrotic syndrome confirms a distinct entity of autosomal recessive nephrosis. Hum Mol Genet. Mar 1996, 4 (11): 2155–8. PMID 8589695. doi:10.1093/hmg/4.11.2155. 
  2. ^ Boute N, Gribouval O, Roselli S, Benessy F, Lee H, Fuchshuber A, Dahan K, Gubler MC, Niaudet P, Antignac C. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat Genet. May 2000, 24 (4): 349–54. PMID 10742096. doi:10.1038/74166. 
  3. ^ Entrez Gene: NPHS2 Nephrosis 2, idiopathic, steroid-resistant (podocin). (原始內容存檔於2019-10-18). 
  4. ^ 4.0 4.1 Schwarz, K; Simons M; Reiser J; Saleem M A; Faul C; Kriz W; Shaw A S; Holzman L B; Mundel P. Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin. J. Clin. Invest. (United States). Dec 2001, 108 (11): 1621–9. ISSN 0021-9738. PMC 200981可免費查閱. PMID 11733557. doi:10.1172/JCI12849. 

延伸閱讀

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