脂聯素受體1

Adiponectin receptor 1
脂聯素受體1
Adiponectin receptor 1; 脂聯素受體1
標識
代號	ADIPOR1; ACDCR1; CGI45; PAQR1; TESBP1A
擴展標識	遺傳學：607945 鼠基因：1919924 同源基因：69199 IUPHAR: GeneCards: ADIPOR1 Gene
基因本體論描述
分子功能	· receptor activity; · protein kinase binding; · hormone binding; · identical protein binding; · protein heterodimerization activity;
細胞成分	· plasma membrane; · membrane; · integral component of membrane;
生物過程	· hormone-mediated signaling pathway; · fatty acid oxidation; · negative regulation of cell growth; · leptin-mediated signaling pathway; · adiponectin-activated signaling pathway; · positive regulation of JAK-STAT cascade; · positive regulation of insulin receptor signaling pathway;
	Sources: Amigo / QuickGO
RNA表達模式
	更多表達數據
直系同源體
物種	人類
Entrez	51094
Ensembl	ENSG00000159346
UniProt	Q96A54
mRNA序列	NM_001290553
蛋白序列	NP_001277482
基因位置	Chr 1:; 202.91 – 202.93 Mb
PubMed查詢	[1]
	閱; 論; 編;

脂聯素受體1（英語：Adiponectin receptor 1，縮寫ADIPOR1）是一種由人類基因 ADIPOR1 編碼的蛋白質^[1]。

結構

ADIPOR1和G蛋白偶聯受體（GPCRs）類似，都擁有7個跨膜結構域（英語：transmembrane domain）。但是ADIPOR1的七跨膜的位置與GPCRs相反，N-端在細胞內，C-端在細胞外，也不能與G蛋白相互作用^[1]。

功能

脂聯素的受體，ADIPOR1和ADIPOR2，能應答球狀或全長的脂聯素信號，促使AMPK（英語：AMP-activated protein kinase）和PPAR-α（英語：Peroxisome proliferator-activated receptor alpha）配體活性增加，以及脂肪酸的氧化和葡萄糖攝取^[1]^[2]。

參考文獻

^ ^1.0 ^1.1 ^1.2 Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. June 2003, 423 (6941): 762–9. PMID 12802337. doi:10.1038/nature01705.
^ Entrez Gene: ADIPOR1 adiponectin receptor 1.

延伸閱讀

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Staiger H, Kaltenbach S, Staiger K; et al. Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism.. Diabetes. 2004, 53 (9): 2195–201. PMID 15331527. doi:10.2337/diabetes.53.9.2195.
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Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Punyadeera C, Zorenc AH, Koopman R; et al. The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle.. Eur. J. Endocrinol. 2005, 152 (3): 427–36. PMID 15757860. doi:10.1530/eje.1.01872.
Hara K, Horikoshi M, Kitazato H; et al. Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes.. Diabetologia. 2005, 48 (7): 1307–14. PMID 15918014. doi:10.1007/s00125-005-1806-3.
Damcott CM, Ott SH, Pollin TI; et al. Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish.. Diabetes. 2005, 54 (7): 2245–50. PMID 15983228. doi:10.2337/diabetes.54.7.2245.
Neumeier M, Weigert J, Schäffler A; et al. Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors.. Biochem. Biophys. Res. Commun. 2006, 334 (3): 924–9. PMID 16023994. doi:10.1016/j.bbrc.2005.06.187.
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[pmid12802337-1] 1.0 ^1.1 ^1.2 Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. June 2003, 423 (6941): 762–9. PMID 12802337. doi:10.1038/nature01705.

[entrez-2] Entrez Gene: ADIPOR1 adiponectin receptor 1.

[1]

[2]