4-羟基雌二醇
外观
4-羟基雌二醇 | |
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IUPAC名 (8R,9S,13S,14S,17S)-13-Methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,4,17-triol | |
别名 | 4-OHE2; Estra-1,3,5(10)-triene-3,4,17β-triol; 3,4,17β-Trihydroxyestra-1,3,5(10)-triene |
识别 | |
CAS号 | 5976-61-4 ![]() |
PubChem | 5282360 |
ChemSpider | 4445523 |
SMILES |
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ChEBI | 62845 |
KEGG | C14209 |
性质 | |
化学式 | C18H24O3 |
摩尔质量 | 288.38 g·mol−1 |
熔点 | 252—253 °C(525—526 K)[1] |
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。 |
4-羟基雌二醇(英语:4-Hydroxyestradiol,缩写4-OHE2,或称为雌甾-1,3,5(10)-三烯-3,4,17β-三醇,estra-1,3,5(10)-triene-3,4,17β-triol)是一种内源性的天然儿茶酚雌激素和雌酮与雌二醇的次要代谢产物[2],带有一定的雌激素活性[2][3]。
参考资料
[编辑]- ^ Hecker, Erich; Walk, Elisabeth. The chemistry of the p-quinols. III. o-Quinone diacetates and amino analogs of natural estrogens. Chemische Berichte, 1960. 93: 2928-2937. ISSN: 0009-2940.
- ^ 2.0 2.1 Michael Oettel; Ekkehard Schillinger. Estrogens and Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens. Springer Science & Business Media. 6 December 2012: 224, 232, 244–245, 249. ISBN 978-3-642-58616-3.
- ^ Bhavnani BR, Nisker JA, Martin J, Aletebi F, Watson L, Milne JK. Comparison of pharmacokinetics of a conjugated equine estrogen preparation (premarin) and a synthetic mixture of estrogens (C.E.S.) in postmenopausal women. J. Soc. Gynecol. Investig. 2000, 7 (3): 175–83. PMID 10865186. doi:10.1016/s1071-5576(00)00049-6.
外部链接
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