卡莫司他：修订间差异

维基百科，自由的百科全书
交互式浏览历史
←上一版本下一版本→
删除的内容 添加的内容
可视化wikitext
InternetArchiveBot（留言 | 贡献）
机器人
1,948,016次编辑
补救1个来源，并将0个来源标记为失效。) #IABot (v2.0.7
InternetArchiveBot（留言 | 贡献）
机器人
1,948,016次编辑
补救2个来源，并将0个来源标记为失效。) #IABot (v2.0.8
第51行： 第51行：


'''卡莫司他'''（{{lang-en|camostat}}，开发代码FOY-305），是一种[[丝氨酸蛋白酶抑制剂]]，在体内有各种功能。被用来治疗某些[[肿瘤]]，并被用来有效地抵抗[[病毒]]感染。还可抑制[[肝脏]][[纤维化]]、肾病或[[胰腺炎]]。<ref>{{Cite journal | pmid = 11779708| year = 2002| last1 = Okuno| first1 = M.| title = Retinoids in liver fibrosis and cancer| journal = Frontiers in Bioscience | volume = 7| issue = 4| pages = d204-18| last2 = Kojima| first2 = S.| last3 = Akita| first3 = K.| last4 = Matsushima-Nishiwaki| first4 = R.| last5 = Adachi| first5 = S.| last6 = Sano| first6 = T.| last7 = Takano| first7 = Y.| last8 = Takai| first8 = K.| last9 = Obora| first9 = A.| last10 = Yasuda| first10 = I.| last11 = Shiratori| first11 = Y.| last12 = Okano| first12 = Y.| last13 = Shimada| first13 = J.| last14 = Suzuki| first14 = Y.| last15 = Muto| first15 = Y.| last16 = Moriwaki| first16 = Y.| doi = 10.2741/A775}}</ref><ref>{{Cite journal | pmid = 18220789| year = 2007| last1 = Hsieh| first1 = H. P.| title = Strategies of development of antiviral agents directed against influenza virus replication| journal = Current Pharmaceutical Design| volume = 13| issue = 34| pages = 3531–42| last2 = Hsu| first2 = J. T.| doi = 10.2174/138161207782794248}}</ref><ref>{{Cite journal | pmid = 22038264| year = 2012| last1 = Kitamura| first1 = K.| title = Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension| journal = Clinical and Experimental Nephrology| volume = 16| issue = 1| pages = 44–8| last2 = Tomita| first2 = K.| doi = 10.1007/s10157-011-0506-1}}</ref><ref>{{Cite journal | pmid = 25666761| pmc = 4774534| year = 2015| last1 = Zhou| first1 = Y.| title = Protease inhibitors targeting coronavirus and filovirus entry| journal = Antiviral Research| volume = 116| pages = 76–84| last2 = Vedantham| first2 = P.| last3 = Lu| first3 = K.| last4 = Agudelo| first4 = J.| last5 = Carrion Jr| first5 = R.| last6 = Nunneley| first6 = J. W.| last7 = Barnard| first7 = D.| last8 = Pöhlmann| first8 = S.| last9 = McKerrow| first9 = J. H.| last10 = Renslo| first10 = A. R.| last11 = Simmons| first11 = G.| doi = 10.1016/j.antiviral.2015.01.011}}</ref><ref>{{Cite journal | pmid = 25766432| year = 2015| last1 = Ueda| first1 = M.| title = The serine protease inhibitor camostat mesilate attenuates the progression of chronic kidney disease through its antioxidant effects| journal = Nephron| volume = 129| issue = 3| pages = 223–32| last2 = Uchimura| first2 = K.| last3 = Narita| first3 = Y.| last4 = Miyasato| first4 = Y.| last5 = Mizumoto| first5 = T.| last6 = Morinaga| first6 = J.| last7 = Hayata| first7 = M.| last8 = Kakizoe| first8 = Y.| last9 = Adachi| first9 = M.| last10 = Miyoshi| first10 = T.| last11 = Shiraishi| first11 = N.| last12 = Kadowaki| first12 = D.| last13 = Sakai| first13 = Y.| last14 = Mukoyama| first14 = M.| last15 = Kitamura| first15 = K.| doi = 10.1159/000375308}}</ref>在日本被批准使用。<ref>{{Cite web | url = https://www.drugs.com/international/camostat.html | title = Camostat | publisher = [[drugs.com]] | accessdate = 2020-03-02 | archive-date = 2020-03-05 | archive-url = https://web.archive.org/web/20200305112048/https://www.drugs.com/international/camostat.html | dead-url = no }}</ref>
'''卡莫司他'''（{{lang-en|camostat}}，开发代码FOY-305），是一种[[丝氨酸蛋白酶抑制剂]]，在体内有各种功能。被用来治疗某些[[肿瘤]]，并被用来有效地抵抗[[病毒]]感染。还可抑制[[肝脏]][[纤维化]]、肾病或[[胰腺炎]]。<ref>{{Cite journal | pmid = 11779708| year = 2002| last1 = Okuno| first1 = M.| title = Retinoids in liver fibrosis and cancer| journal = Frontiers in Bioscience | volume = 7| issue = 4| pages = d204-18| last2 = Kojima| first2 = S.| last3 = Akita| first3 = K.| last4 = Matsushima-Nishiwaki| first4 = R.| last5 = Adachi| first5 = S.| last6 = Sano| first6 = T.| last7 = Takano| first7 = Y.| last8 = Takai| first8 = K.| last9 = Obora| first9 = A.| last10 = Yasuda| first10 = I.| last11 = Shiratori| first11 = Y.| last12 = Okano| first12 = Y.| last13 = Shimada| first13 = J.| last14 = Suzuki| first14 = Y.| last15 = Muto| first15 = Y.| last16 = Moriwaki| first16 = Y.| doi = 10.2741/A775}}</ref><ref>{{Cite journal | pmid = 18220789| year = 2007| last1 = Hsieh| first1 = H. P.| title = Strategies of development of antiviral agents directed against influenza virus replication| journal = Current Pharmaceutical Design| volume = 13| issue = 34| pages = 3531–42| last2 = Hsu| first2 = J. T.| doi = 10.2174/138161207782794248}}</ref><ref>{{Cite journal | pmid = 22038264| year = 2012| last1 = Kitamura| first1 = K.| title = Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension| journal = Clinical and Experimental Nephrology| volume = 16| issue = 1| pages = 44–8| last2 = Tomita| first2 = K.| doi = 10.1007/s10157-011-0506-1}}</ref><ref>{{Cite journal | pmid = 25666761| pmc = 4774534| year = 2015| last1 = Zhou| first1 = Y.| title = Protease inhibitors targeting coronavirus and filovirus entry| journal = Antiviral Research| volume = 116| pages = 76–84| last2 = Vedantham| first2 = P.| last3 = Lu| first3 = K.| last4 = Agudelo| first4 = J.| last5 = Carrion Jr| first5 = R.| last6 = Nunneley| first6 = J. W.| last7 = Barnard| first7 = D.| last8 = Pöhlmann| first8 = S.| last9 = McKerrow| first9 = J. H.| last10 = Renslo| first10 = A. R.| last11 = Simmons| first11 = G.| doi = 10.1016/j.antiviral.2015.01.011}}</ref><ref>{{Cite journal | pmid = 25766432| year = 2015| last1 = Ueda| first1 = M.| title = The serine protease inhibitor camostat mesilate attenuates the progression of chronic kidney disease through its antioxidant effects| journal = Nephron| volume = 129| issue = 3| pages = 223–32| last2 = Uchimura| first2 = K.| last3 = Narita| first3 = Y.| last4 = Miyasato| first4 = Y.| last5 = Mizumoto| first5 = T.| last6 = Morinaga| first6 = J.| last7 = Hayata| first7 = M.| last8 = Kakizoe| first8 = Y.| last9 = Adachi| first9 = M.| last10 = Miyoshi| first10 = T.| last11 = Shiraishi| first11 = N.| last12 = Kadowaki| first12 = D.| last13 = Sakai| first13 = Y.| last14 = Mukoyama| first14 = M.| last15 = Kitamura| first15 = K.| doi = 10.1159/000375308}}</ref>在日本被批准使用。<ref>{{Cite web | url = https://www.drugs.com/international/camostat.html | title = Camostat | publisher = [[drugs.com]] | accessdate = 2020-03-02 | archive-date = 2020-03-05 | archive-url = https://web.archive.org/web/20200305112048/https://www.drugs.com/international/camostat.html | dead-url = no }}</ref>
2020年德国科学家在[[細胞 (期刊)|细胞]]杂志上发表论文指出甲磺酸卡莫司他（{{lang-en|camostat mesylate}}）积极对抗[[TMPRSS2]]，部分阻断SARS-2-S-驱动的进入Caco-2和Vero195 TMPRSS2细胞。<ref>[https://www.cell.com/cell/fulltext/S0092-8674(20)30229-4 SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically-proven protease inhibitor]</ref>
2020年德国科学家在[[細胞 (期刊)|细胞]]杂志上发表论文指出甲磺酸卡莫司他（{{lang-en|camostat mesylate}}）积极对抗[[TMPRSS2]]，部分阻断SARS-2-S-驱动的进入Caco-2和Vero195 TMPRSS2细胞。<ref>{{Cite web |url=https://www.cell.com/cell/fulltext/S0092-8674(20)30229-4 |title=SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically-proven protease inhibitor |access-date=2020-03-05 |archive-date=2021-02-24 |archive-url=https://web.archive.org/web/20210224061325/https://www.cell.com/cell/fulltext/S0092-8674(20)30229-4 |dead-url=no }}</ref>


==来源==
==来源==

2021年8月17日 (二) 21:50的版本

卡莫司他
臨床資料
商品名（英语：Drug nomenclature）Foipan
AHFS/Drugs.com国际药品名称
给药途径Oral
ATC碼
法律規範狀態
法律規範
  • 美：Not FDA approved
  • 处方药（℞-only）
识别信息
  • N,N-Dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)phenylacetate
CAS号59721-28-7  checkY
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)
化学信息
化学式C20H22N4O5
摩尔质量398.42 g·mol−1
3D模型（JSmol（英语：JSmol））
  • CN(C)C(=O)COC(=O)CC1=CC=C(C=C1)OC(=O)C2=CC=C(C=C2)N=C(N)N
  • InChI=1S/C20H22N4O5/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22/h3-10H,11-12H2,1-2H3,(H4,21,22,23) checkY
  • Key:XASIMHXSUQUHLV-UHFFFAOYSA-N checkY

卡莫司他（英語：camostat，开发代码FOY-305），是一种丝氨酸蛋白酶抑制剂，在体内有各种功能。被用来治疗某些肿瘤，并被用来有效地抵抗病毒感染。还可抑制肝脏纤维化、肾病或胰腺炎。[1][2][3][4][5]在日本被批准使用。[6] 2020年德国科学家在细胞杂志上发表论文指出甲磺酸卡莫司他（英語：camostat mesylate）积极对抗TMPRSS2，部分阻断SARS-2-S-驱动的进入Caco-2和Vero195 TMPRSS2细胞。[7]

来源

  1. ^ Okuno, M.; Kojima, S.; Akita, K.; Matsushima-Nishiwaki, R.; Adachi, S.; Sano, T.; Takano, Y.; Takai, K.; Obora, A.; Yasuda, I.; Shiratori, Y.; Okano, Y.; Shimada, J.; Suzuki, Y.; Muto, Y.; Moriwaki, Y. Retinoids in liver fibrosis and cancer. Frontiers in Bioscience. 2002, 7 (4): d204–18. PMID 11779708. doi:10.2741/A775. 
  2. ^ Hsieh, H. P.; Hsu, J. T. Strategies of development of antiviral agents directed against influenza virus replication. Current Pharmaceutical Design. 2007, 13 (34): 3531–42. PMID 18220789. doi:10.2174/138161207782794248. 
  3. ^ Kitamura, K.; Tomita, K. Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension. Clinical and Experimental Nephrology. 2012, 16 (1): 44–8. PMID 22038264. doi:10.1007/s10157-011-0506-1. 
  4. ^ Zhou, Y.; Vedantham, P.; Lu, K.; Agudelo, J.; Carrion Jr, R.; Nunneley, J. W.; Barnard, D.; Pöhlmann, S.; McKerrow, J. H.; Renslo, A. R.; Simmons, G. Protease inhibitors targeting coronavirus and filovirus entry. Antiviral Research. 2015, 116: 76–84. PMC 4774534 可免费查阅. PMID 25666761. doi:10.1016/j.antiviral.2015.01.011. 
  5. ^ Ueda, M.; Uchimura, K.; Narita, Y.; Miyasato, Y.; Mizumoto, T.; Morinaga, J.; Hayata, M.; Kakizoe, Y.; Adachi, M.; Miyoshi, T.; Shiraishi, N.; Kadowaki, D.; Sakai, Y.; Mukoyama, M.; Kitamura, K. The serine protease inhibitor camostat mesilate attenuates the progression of chronic kidney disease through its antioxidant effects. Nephron. 2015, 129 (3): 223–32. PMID 25766432. doi:10.1159/000375308. 
  6. ^ Camostat. drugs.com. [2020-03-02]. （原始内容存档于2020-03-05）. 
  7. ^ SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically-proven protease inhibitor. [2020-03-05]. （原始内容存档于2021-02-24）. 
取自“https://zh.wikipedia.org/w/index.php?title=卡莫司他&oldid=67192268”