戊二酰亚胺：修订间差异

维基百科，自由的百科全书
以互动方式浏览历史
←上一版本下一版本→
删除的内容 添加的内容
可视化wikitext
InternetArchiveBot（留言 | 贡献）
机器人
1,954,486次编辑
补救3个来源，并将0个来源标记为失效。) #IABot (v2.0.9.2
第24行： 第24行：
'''戊二酰亚胺'''是一种[[有机化合物]]，分子式为(CH<sub>2</sub>)<sub>3</sub>(CO)<sub>2</sub>NH。它是一种白色固体。该化合物在[[戊二酸]]酰胺脱水后形成。<ref>{{Cite journal |last=Paris |first=G. |last2=Berlinguet |first2=L. |last3=Gaudry |first3=R. |last4=English, Jr. |first4=J. |last5=Dayan |first5=J. E. |year=1957 |title=Glutaric Acid and Glutarimide |journal=Organic Syntheses |volume=37 |page=47 |doi=10.15227/orgsyn.037.0047}}</ref>
'''戊二酰亚胺'''是一种[[有机化合物]]，分子式为(CH<sub>2</sub>)<sub>3</sub>(CO)<sub>2</sub>NH。它是一种白色固体。该化合物在[[戊二酸]]酰胺脱水后形成。<ref>{{Cite journal |last=Paris |first=G. |last2=Berlinguet |first2=L. |last3=Gaudry |first3=R. |last4=English, Jr. |first4=J. |last5=Dayan |first5=J. E. |year=1957 |title=Glutaric Acid and Glutarimide |journal=Organic Syntheses |volume=37 |page=47 |doi=10.15227/orgsyn.037.0047}}</ref>


戊二酰亚胺有时称作2,6-哌啶二酮。它是多种[[药物]]的核心，包括[[沙利度胺]]，一种用于治疗[[多发性骨髓瘤]]<ref>{{Cite web |title=A to Z List of Cancer Drugs: Thalidomide |url=https://www.cancer.gov/about-cancer/treatment/drugs/thalidomide |publisher=National Cancer Institute |access-date=20 September 2021}}</ref>和[[麻风病]]的药物；<ref name="nyt-fda">{{Cite news|url=https://www.nytimes.com/1998/07/17/us/thalidomide-approved-to-treat-leprosy-with-other-uses-seen.html|title=Thalidomide Approved to Treat Leprosy, With Other Uses Seen|work=New York Times|first=Sheryl Gay|author=Stolberg|accessdate=20 September 2021|date=17 July 1998}}</ref>和[[放线菌酮]]，一种有效的蛋白质合成抑制剂。<ref>Hugh D. Sisler, Malcolm R. Siegel; [https://link.springer.com/chapter/10.1007/978-3-642-46051-7_21 Cycloheximide and Other Glutarimide Antibiotics]; Mechanism of Action pp 283-307</ref>
戊二酰亚胺有时称作2,6-哌啶二酮。它是多种[[药物]]的核心，包括[[沙利度胺]]，一种用于治疗[[多发性骨髓瘤]]<ref>{{Cite web |title=A to Z List of Cancer Drugs: Thalidomide |url=https://www.cancer.gov/about-cancer/treatment/drugs/thalidomide |publisher=National Cancer Institute |access-date=20 September 2021 |archive-date=2022-08-15 |archive-url=https://web.archive.org/web/20220815180447/https://www.cancer.gov/about-cancer/treatment/drugs/thalidomide |dead-url=no }}</ref>和[[麻风病]]的药物；<ref name="nyt-fda">{{Cite news|url=https://www.nytimes.com/1998/07/17/us/thalidomide-approved-to-treat-leprosy-with-other-uses-seen.html|title=Thalidomide Approved to Treat Leprosy, With Other Uses Seen|work=New York Times|first=Sheryl Gay|author=Stolberg|accessdate=20 September 2021|date=17 July 1998|archive-date=2020-12-03|archive-url=https://web.archive.org/web/20201203003055/https://www.nytimes.com/1998/07/17/us/thalidomide-approved-to-treat-leprosy-with-other-uses-seen.html|dead-url=no}}</ref>和[[放线菌酮]]，一种有效的蛋白质合成抑制剂。<ref>Hugh D. Sisler, Malcolm R. Siegel; [https://link.springer.com/chapter/10.1007/978-3-642-46051-7_21 Cycloheximide and Other Glutarimide Antibiotics] {{Wayback|url=https://link.springer.com/chapter/10.1007/978-3-642-46051-7_21 |date=20220804175044 }}; Mechanism of Action pp 283-307</ref>


== 参考文献 ==
== 参考文献 ==

2022年10月21日 (五) 22:41的版本

戊二酰亚胺
Skeletal formula
Ball-and-stick model
IUPAC名
Piperidine-2,6-dione
哌啶-2,6-二酮
别名 2,6-Diketopiperidine
识别
CAS号 1121-89-7  checkY
PubChem 70726
ChemSpider 63891
SMILES
 
  • C1CC(=O)NC(=O)C1
性质
化学式 C5H7NO2
摩尔质量 113.11 g/mol g·mol⁻¹
熔点 155-157 °C[1]
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

戊二酰亚胺是一种有机化合物，分子式为(CH2)3(CO)2NH。它是一种白色固体。该化合物在戊二酸酰胺脱水后形成。[2]

戊二酰亚胺有时称作2,6-哌啶二酮。它是多种药物的核心，包括沙利度胺，一种用于治疗多发性骨髓瘤[3]和麻风病的药物；[4]和放线菌酮，一种有效的蛋白质合成抑制剂。[5]

参考文献

  1. ^ Glutarimide - Sigma-Aldrich
  2. ^ Paris, G.; Berlinguet, L.; Gaudry, R.; English, Jr., J.; Dayan, J. E. Glutaric Acid and Glutarimide. Organic Syntheses. 1957, 37: 47. doi:10.15227/orgsyn.037.0047. 
  3. ^ A to Z List of Cancer Drugs: Thalidomide. National Cancer Institute. [20 September 2021]. （原始内容存档于2022-08-15）. 
  4. ^ Stolberg, Sheryl Gay. Thalidomide Approved to Treat Leprosy, With Other Uses Seen. New York Times. 17 July 1998 [20 September 2021]. （原始内容存档于2020-12-03）. 
  5. ^ Hugh D. Sisler, Malcolm R. Siegel; Cycloheximide and Other Glutarimide Antibiotics （页面存档备份，存于互联网档案馆）; Mechanism of Action pp 283-307
取自“https://zh.wikipedia.org/w/index.php?title=戊二酰亚胺&oldid=74193998”