NNC 45-0095

**NNC 45-0095**
臨床資料
其他名稱	NNC-450095
藥物類別（英语：Drug class）	選擇性雌激素受體調節物
识别信息
	IUPAC命名法 4-(1-ethylpyrrolo[2,1,5-cd]indolizin-2-yl)phenol; ;
CAS号	217318-90-6
PubChem CID	9903336;
ChemSpider	8078990;
UNII	IS4M82C29X;
ChEMBL	ChEMBL420017;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID60432621 ;
化学信息
化学式	C18H15NO
摩尔质量	261.32 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES CCC1=C(C2=CC=C3N2C1=CC=C3)C4=CC=C(C=C4)O;
	InChI InChI=1S/C18H15NO/c1-2-15-16-5-3-4-13-8-11-17(19(13)16)18(15)12-6-9-14(20)10-7-12/h3-11,20H,2H2,1H3; Key:GBHFDPQPLXKNIU-UHFFFAOYSA-N;

NNC 45-0095是一种含氮有机化合物，化学式C₁₈H₁₇NO，可作为非甾体選擇性雌激素受體調節物（SERMs），由诺和诺德开发，用于治疗骨質疏鬆症，从未上市销售。^[1]^[2]^[3]^[4]^[5]

参考文献[编辑]

^ Jørgensen AS, Jacobsen P, Christiansen LB, Bury PS, Kanstrup A, Thorpe SM, et al. Synthesis and pharmacology of a novel pyrrolo[2,1,5-cd] indolizine (NNC 45-0095), a high affinity non-steroidal agonist for the estrogen receptor. Bioorganic & Medicinal Chemistry Letters. February 2000, 10 (4): 399–402. PMID 10714509. doi:10.1016/S0960-894X(00)00015-9.
^ Sharma V, Kumar V. Indolizine: a biologically active moiety. Medicinal Chemistry Research. 2014, 23 (8): 3593–3606. ISSN 1054-2523. S2CID 2643469. doi:10.1007/s00044-014-0940-1.
^ Wallace OB, Richardson TI, Dodge JA. Estrogen receptor modulators: relationships of ligand structure, receptor affinity and functional activity. Current Topics in Medicinal Chemistry. 2003, 3 (14): 1663–1682. PMID 14683521. doi:10.2174/1568026033451727.
^ Meegan MJ, Lloyd DG. Understanding the Molecular Mechanism of Action of Estrogen Receptor Modulators. Frontiers in Medicinal Chemistry-Online. Atta-ur-Rahman, Reitz AB (编). Frontiers in Medicinal Chemistry 2. Bentham Science Publishers. January 2005: 183–231 (206). ISBN 978-1-60805-205-9. |issue=被忽略 (帮助)
^ NNC 450095. AdisInsight. Springer Nature Switzerland AG.