無機焦磷酸酶

焦磷酸酶（無機）2
識別
符號	PPA2
Entrez	27068
HUGO	28883
OMIM	609988
RefSeq	NM_176869
UniProt	Q9H2U2
其他資料
基因座	4 q25

焦磷酸酶（無機）1
	從嗜熱高溫球菌中分離得到的無機焦磷酸酶的結構
識別
符號	PPA1
替換符號	PP
Entrez	5464
HUGO	9226
OMIM	179030
RefSeq	NM_021129
UniProt	Q15181
其他資料
EC編號	3.6.1.1
基因座	10 q11.1-q24

無機焦磷酸酶（英語：Inorganic Pyrophosphatase，簡稱為焦磷酸酶）是一種催化一分子焦磷酸鹽轉化為兩分子磷酸鹽離子的酶^[1]。這是一個高放能的反應，因此此反應可偶聯到一些熱力學上不利的轉化，以便驅動這些轉化進行到完全^[2]。此酶的功能乃是在脂代謝（包括脂合成與降解）、鈣吸收以及骨形成^[3]^[4]和DNA合成^[5]中扮演重要角色，其他生物化學轉化也是如此^[6]^[7]。

外部連結[編輯]

醫學主題詞表（MeSH）：pyrophosphatases

參考文獻[編輯]

^ Harold FM. Inorganic polyphosphates in biology: structure, metabolism, and function. Bacteriol Rev. December 1966, 30 (4): 772–94. PMC 441015 . PMID 5342521.
^ Terkeltaub RA. Inorganic pyrophosphate generation and disposition in pathophysiology. Am. J. Physiol., Cell Physiol. July 2001, 281 (1): C1–C11. PMID 11401820.
^ Orimo H, Ohata M, Fujita T. Role of inorganic pyrophosphatase in the mechanism of action of parathyroid hormone and calcitonin. Endocrinology. September 1971, 89 (3): 852–8. PMID 4327778. doi:10.1210/endo-89-3-852.
^ Poole KE, Reeve J. Parathyroid hormone - a bone anabolic and catabolic agent. Curr Opin Pharmacol. December 2005, 5 (6): 612–7. PMID 16181808. doi:10.1016/j.coph.2005.07.004.
^ Nelson, David L.; Cox, Michael M. Lehninger Principles of Biochemistry, 3rd ed.. New York: Worth Publishers. 2000: 937. ISBN 1-57259-153-6.
^ Ko KM, Lee W, Yu JR, Ahnn J. PYP-1, inorganic pyrophosphatase, is required for larval development and intestinal function in C. elegans. FEBS Lett. November 2007, 581 (28): 5445–53. PMID 17981157. doi:10.1016/j.febslet.2007.10.047.
^ Usui Y, Uematsu T, Uchihashi T; et al. Inorganic polyphosphate induces osteoblastic differentiation. J. Dent. Res. May 2010, 89 (5): 504–9. PMID 20332330. doi:10.1177/0022034510363096.

[pmid5342521-1] Harold FM. Inorganic polyphosphates in biology: structure, metabolism, and function. Bacteriol Rev. December 1966, 30 (4): 772–94. PMC 441015 . PMID 5342521.

[pmid11401820-2] Terkeltaub RA. Inorganic pyrophosphate generation and disposition in pathophysiology. Am. J. Physiol., Cell Physiol. July 2001, 281 (1): C1–C11. PMID 11401820.

[pmid4327778-3] Orimo H, Ohata M, Fujita T. Role of inorganic pyrophosphatase in the mechanism of action of parathyroid hormone and calcitonin. Endocrinology. September 1971, 89 (3): 852–8. PMID 4327778. doi:10.1210/endo-89-3-852.

[pmid16181808-4] Poole KE, Reeve J. Parathyroid hormone - a bone anabolic and catabolic agent. Curr Opin Pharmacol. December 2005, 5 (6): 612–7. PMID 16181808. doi:10.1016/j.coph.2005.07.004.

[lehninger-5] Nelson, David L.; Cox, Michael M. Lehninger Principles of Biochemistry, 3rd ed.. New York: Worth Publishers. 2000: 937. ISBN 1-57259-153-6.

[pmid17981157-6] Ko KM, Lee W, Yu JR, Ahnn J. PYP-1, inorganic pyrophosphatase, is required for larval development and intestinal function in C. elegans. FEBS Lett. November 2007, 581 (28): 5445–53. PMID 17981157. doi:10.1016/j.febslet.2007.10.047.

[pmid20332330-7] Usui Y, Uematsu T, Uchihashi T; et al. Inorganic polyphosphate induces osteoblastic differentiation. J. Dent. Res. May 2010, 89 (5): 504–9. PMID 20332330. doi:10.1177/0022034510363096.

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