1-苄基哌嗪

1-苄基哌嗪
臨床資料
给药途径	Oral, intravenous, insufflation
ATC碼	未分配;
法律規範狀態
法律規範	澳：已禁止（S9）; 加：Schedule III; 德：Anlage II; NZ：Class C; 英：处方药（℞-only） (POM); 美：附表I;
藥物動力學數據
生物利用度	Unknown
药物代谢	Hepatic
生物半衰期	5.5 Hours
排泄途徑	Renal
识别信息
	IUPAC命名法 1-Benzylpiperazine; ;
CAS号	2759-28-6
PubChem CID	75994;
ChemSpider	68493 ;
UNII	3UG152ZU0E;
KEGG	C22780;
ChEBI	CHEBI:83537 ;
ChEMBL	ChEMBL113600 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID0022197 ;
ECHA InfoCard	100.018.567
化学信息
化学式	C11H16N2
摩尔质量	176.26 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES C1(CN2CCNCC2)=CC=CC=C1;
	InChI InChI=1S/C11H16N2/c1-2-4-11(5-3-1)10-13-8-6-12-7-9-13/h1-5,12H,6-10H2 ; Key:IQXXEPZFOOTTBA-UHFFFAOYSA-N ;

1-苄基哌嗪是一种有机化合物，化学式为C₁₁H₁₆N₂。它可由哌嗪和氯化苄或溴化苄反应得到，反应中生成的二苄基哌嗪副产物可以通过结晶除去。^[5]^[6]

参考文献

^ Benzylpiperazine [BZP], namely 1-benzylpiperazine and its salts, isomers and salts of isomers. Controlled Drugs and Substances Act: Schedule III. Justice Laws Website, Government of Canada. 14 January 2023.
^ Amending Schedule III to the Controlled Drugs and Substances Act (BZP and TFMPP).. Canada Gazette. [24 November 2012].
^ Antia U, Lee HS, Kydd RR, Tingle MD, Russell BR. Pharmacokinetics of 'party pill' drug N-benzylpiperazine (BZP) in healthy human participants. Forensic Science International. April 2009, 186 (1–3): 63–67. PMID 19261399. doi:10.1016/j.forsciint.2009.01.015.
^ Anvisa. RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-07-24 [2023-08-27]. （原始内容存档于2023-08-27）（巴西葡萄牙语）.
^ Putt, Karson S; Chen, Grace W; Pearson, Jennifer M; Sandhorst, Joseph S; Hoagland, Martin S; Kwon, Jung-Taek; Hwang, Soon-Kyung; Jin, Hua; Churchwell, Mona I; Cho, Myung-Haing (2006). Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol, 2(10), 543–550. doi:10.1038/nchembio814
^ Berenger Biannic, Joseph J. Bozell and Thomas Elder. Steric effects in the design of Co-Schiff base complexes for the catalytic oxidation of lignin models to para-benzoquinones. Green Chem., 2014,16, 3635-3642. doi:10.1039/C4GC00709C.

[1] Benzylpiperazine [BZP], namely 1-benzylpiperazine and its salts, isomers and salts of isomers. Controlled Drugs and Substances Act: Schedule III. Justice Laws Website, Government of Canada. 14 January 2023.

[2] Amending Schedule III to the Controlled Drugs and Substances Act (BZP and TFMPP).. Canada Gazette. [24 November 2012].

[3] Antia U, Lee HS, Kydd RR, Tingle MD, Russell BR. Pharmacokinetics of 'party pill' drug N-benzylpiperazine (BZP) in healthy human participants. Forensic Science International. April 2009, 186 (1–3): 63–67. PMID 19261399. doi:10.1016/j.forsciint.2009.01.015.

[4] Anvisa. RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-07-24 [2023-08-27]. （原始内容存档于2023-08-27）（巴西葡萄牙语）.

[5] Putt, Karson S; Chen, Grace W; Pearson, Jennifer M; Sandhorst, Joseph S; Hoagland, Martin S; Kwon, Jung-Taek; Hwang, Soon-Kyung; Jin, Hua; Churchwell, Mona I; Cho, Myung-Haing (2006). Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol, 2(10), 543–550. doi:10.1038/nchembio814

[6] Berenger Biannic, Joseph J. Bozell and Thomas Elder. Steric effects in the design of Co-Schiff base complexes for the catalytic oxidation of lignin models to para-benzoquinones. Green Chem., 2014,16, 3635-3642. doi:10.1039/C4GC00709C.

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