早幼粒细胞白血病蛋白
外观
早幼粒细胞白血病蛋白是指可能的转录因子可能的转录因子(英語:Probable transcription factor PML),是一个由人类基因 PML 编码的抑癌蛋白。
功能
互作
早幼粒细胞白血病蛋白可与下列蛋白質发生交互作用:
- ANKRD2,[1]
- CREB-binding protein,[2][3][4]
- Cyclin T1,[5]
- Death associated protein 6,[6][7][8][9]
- GATA2,[10]
- HDAC1,[11][12]
- HDAC3,[12]
- HHEX,[13]
- MAPK11,[14]
- MYB,[15]
- Mdm2,[16][17][18][19]
- Nerve Growth factor IB,[20]
- Nuclear receptor co-repressor 1,[11]
- Nuclear receptor co-repressor 2,[11][21]
- P53,[16][22][23]
- RPL11,[17]
- 视网膜母细胞瘤蛋白[24]
- 视黄酸受体α,[2]
- SIN3A,[11]
- SKI protein,[11]
- STAT3,[25]
- Serum response factor[3] and
- Small ubiquitin-related modifier 1,[26][27]
- Sp1 transcription factor,[28]
- TOPBP1,[29]
- Thymine-DNA glycosylase,[30] and
- Zinc finger and BTB domain-containing protein 16.[31]
参见
参考文献
- ^ Kojic, S; Medeot, E; Guccione, E; Krmac, H; Zara, I; Martinelli, V; et al. The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle. J. Mol. Biol. May 2004, 339 (2): 313–25. PMID 15136035. doi:10.1016/j.jmb.2004.03.071. 已忽略未知参数
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(帮助) - ^ 2.0 2.1 Zhong, S; Delva, L; Rachez, C; Cenciarelli, C; Gandini, D; Zhang, H; et al. A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins. Nat. Genet. Nov 1999, 23 (3): 287–95. PMID 10610177. doi:10.1038/15463. 已忽略未知参数
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(帮助) - ^ 3.0 3.1 Matsuzaki, K; Minami, T; Tojo, M; Honda, Y; Saitoh, N; Nagahiro, S; et al. PML-nuclear bodies are involved in cellular serum response. Genes Cells. Mar 2003, 8 (3): 275–86. PMID 12622724. 已忽略未知参数
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(帮助) - ^ Doucas, V; Tini, M; Egan, DA; Evans, RM. Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling. Proc. Natl. Acad. Sci. U.S.A. Mar 1999, 96 (6): 2627–32. PMC 15819 . PMID 10077561. 已忽略未知参数
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(帮助) - ^ Marcello, A; Ferrari, A; Pellegrini, V; Pegoraro, G; Lusic, M; Beltram, F; et al. Recruitment of human cyclin T1 to nuclear bodies through direct interaction with the PML protein. EMBO J. May 2003, 22 (9): 2156–66. PMC 156077 . PMID 12727882. doi:10.1093/emboj/cdg205. 已忽略未知参数
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(帮助) - ^ Ishov, AM; Sotnikov, AG; Negorev, D; Vladimirova, OV; Neff, N; Kamitani, T; et al. PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1. J. Cell Biol. Oct 1999, 147 (2): 221–34. PMC 2174231 . PMID 10525530. 已忽略未知参数
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(帮助) - ^ Li, H; Leo, C; Zhu, J; Wu, X; O'Neil, J; Park, EJ; et al. Sequestration and inhibition of Daxx-mediated transcriptional repression by PML. Mol. Cell. Biol. Mar 2000, 20 (5): 1784–96. PMC 85360 . PMID 10669754. 已忽略未知参数
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(帮助) - ^ Lehembre, F; Müller, S; Pandolfi, PP; Dejean, A. Regulation of Pax3 transcriptional activity by SUMO-1-modified PML. Oncogene. Jan 2001, 20 (1): 1–9. PMID 11244500. doi:10.1038/sj.onc.1204063. 已忽略未知参数
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(帮助) - ^ Zhong, S; Salomoni, P; Ronchetti, S; Guo, A; Ruggero, D; Pandolfi, PP. Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis. J. Exp. Med. Feb 2000, 191 (4): 631–40. PMC 2195846 . PMID 10684855. 已忽略未知参数
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(帮助) - ^ Tsuzuki, S; Towatari, M; Saito, H; Enver, T. Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein. Mol. Cell. Biol. Sep 2000, 20 (17): 6276–86. PMC 86102 . PMID 10938104. 已忽略未知参数
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(帮助) - ^ 11.0 11.1 11.2 11.3 11.4 Khan, MM; Nomura, T; Kim, H; Kaul, SC; Wadhwa, R; Shinagawa, T; et al. Role of PML and PML-RARalpha in Mad-mediated transcriptional repression. Mol. Cell. Jun 2001, 7 (6): 1233–43. PMID 11430826. 已忽略未知参数
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(帮助) - ^ 12.0 12.1 Wu, WS; Vallian, S; Seto, E; Yang, WM; Edmondson, D; Roth, S; et al. The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases. Mol. Cell. Biol. Apr 2001, 21 (7): 2259–68. PMC 86860 . PMID 11259576. doi:10.1128/MCB.21.7.2259-2268.2001. 已忽略未知参数
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(帮助) - ^ Topcu, Z; Mack, DL; Hromas, RA; Borden, KL. The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control. Oncogene. Nov 1999, 18 (50): 7091–100. PMID 10597310. doi:10.1038/sj.onc.1203201. 已忽略未知参数
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(帮助) - ^ Shin, J; Park, B; Cho, S; Lee, S; Kim, Y; Lee, SO; et al. Promyelocytic leukemia is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase. J. Biol. Chem. Sep 2004, 279 (39): 40994–1003. PMID 15273249. doi:10.1074/jbc.M407369200. 已忽略未知参数
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(帮助) - ^ Dahle, Ø; Bakke, O; Gabrielsen, OS. c-Myb associates with PML in nuclear bodies in hematopoietic cells. Exp. Cell Res. Jul 2004, 297 (1): 118–26. PMID 15194430. doi:10.1016/j.yexcr.2004.03.014. 已忽略未知参数
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(帮助) - ^ 16.0 16.1 Kurki, S; Latonen, L; Laiho, M. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. J. Cell. Sci. Oct 2003, 116 (Pt 19): 3917–25. PMID 12915590. doi:10.1242/jcs.00714. 已忽略未知参数
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(帮助) - ^ 17.0 17.1 Bernardi, R; Scaglioni, PP; Bergmann, S; Horn, HF; Vousden, KH; Pandolfi, PP. PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Nat. Cell Biol. Jul 2004, 6 (7): 665–72. PMID 15195100. doi:10.1038/ncb1147. 已忽略未知参数
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(帮助) - ^ Zhu, H; Wu, L; Maki, CG. MDM2 and promyelocytic leukemia antagonize each other through their direct interaction with p53. J. Biol. Chem. Dec 2003, 278 (49): 49286–92. PMID 14507915. doi:10.1074/jbc.M308302200. 已忽略未知参数
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(帮助) - ^ Wei, X; Yu, ZK; Ramalingam, A; Grossman, SR; Yu, JH; Bloch, DB; et al. Physical and functional interactions between PML and MDM2. J. Biol. Chem. Aug 2003, 278 (31): 29288–97. PMID 12759344. doi:10.1074/jbc.M212215200. 已忽略未知参数
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(帮助) - ^ Wu, WS; Xu, ZX; Ran, R; Meng, F; Chang, KS. Promyelocytic leukemia protein PML inhibits Nur77-mediated transcription through specific functional interactions. Oncogene. May 2002, 21 (24): 3925–33. PMID 12032831. doi:10.1038/sj.onc.1205491. 已忽略未知参数
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(帮助) - ^ Hong, SH; Yang, Z; Privalsky, ML. Arsenic trioxide is a potent inhibitor of the interaction of SMRT corepressor with Its transcription factor partners, including the PML-retinoic acid receptor alpha oncoprotein found in human acute promyelocytic leukemia. Mol. Cell. Biol. Nov 2001, 21 (21): 7172–82. PMC 99892 . PMID 11585900. doi:10.1128/MCB.21.21.7172-7182.2001. 已忽略未知参数
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(帮助) - ^ Fogal, V; Gostissa, M; Sandy, P; Zacchi, P; Sternsdorf, T; Jensen, K; et al. Regulation of p53 activity in nuclear bodies by a specific PML isoform. EMBO J. Nov 2000, 19 (22): 6185–95. PMC 305840 . PMID 11080164. doi:10.1093/emboj/19.22.6185. 已忽略未知参数
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(帮助) - ^ Guo, A; Salomoni, P; Luo, J; Shih, A; Zhong, S; Gu, W; et al. The function of PML in p53-dependent apoptosis. Nat. Cell Biol. Oct 2000, 2 (10): 730–6. PMID 11025664. doi:10.1038/35036365. 已忽略未知参数
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(帮助) - ^ Alcalay, M; Tomassoni, L; Colombo, E; Stoldt, S; Grignani, F; Fagioli, M; et al. The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein. Mol. Cell. Biol. Feb 1998, 18 (2): 1084–93. PMC 108821 . PMID 9448006. 已忽略未知参数
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(帮助) - ^ Kawasaki, A; Matsumura, I; Kataoka, Y; Takigawa, E; Nakajima, K; Kanakura, Y. Opposing effects of PML and PML/RAR alpha on STAT3 activity. Blood. May 2003, 101 (9): 3668–73. PMID 12506013. doi:10.1182/blood-2002-08-2474. 已忽略未知参数
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(帮助) - ^ Lin, DY; Shih, HM. Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration. J. Biol. Chem. Jul 2002, 277 (28): 25446–56. PMID 11948183. doi:10.1074/jbc.M200633200. 已忽略未知参数
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(帮助) - ^ Kamitani, T; Nguyen, HP; Kito, K; Fukuda-Kamitani, T; Yeh, ET. Covalent modification of PML by the sentrin family of ubiquitin-like proteins. J. Biol. Chem. Feb 1998, 273 (6): 3117–20. PMID 9452416. 已忽略未知参数
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(帮助) - ^ Vallian, S; Chin, KV; Chang, KS. The promyelocytic leukemia protein interacts with Sp1 and inhibits its transactivation of the epidermal growth factor receptor promoter. Mol. Cell. Biol. Dec 1998, 18 (12): 7147–56. PMC 109296 . PMID 9819401. 已忽略未知参数
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(帮助) - ^ Xu, ZX; Timanova-Atanasova, A; Zhao, RX; Chang, KS. PML colocalizes with and stabilizes the DNA damage response protein TopBP1. Mol. Cell. Biol. Jun 2003, 23 (12): 4247–56. PMC 156140 . PMID 12773567. 已忽略未知参数
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(帮助) - ^ Takahashi, H; Hatakeyama, S; Saitoh, H; Nakayama, KI. Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein. J. Biol. Chem. Feb 2005, 280 (7): 5611–21. PMID 15569683. doi:10.1074/jbc.M408130200. 已忽略未知参数
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(帮助) - ^ Koken, MH; Reid, A; Quignon, F; Chelbi-Alix, MK; Davies, JM; Kabarowski, JH; et al. Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies. Proc. Natl. Acad. Sci. U.S.A. Sep 1997, 94 (19): 10255–60. PMC 23349 . PMID 9294197. 已忽略未知参数
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延伸阅读
- Zhong, S; Salomoni, P; Pandolfi, PP. The transcriptional role of PML and the nuclear body. Nat. Cell Biol. 2000, 2 (5): E85–90. PMID 10806494. doi:10.1038/35010583. 已忽略未知参数
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(帮助) - Jensen, K; Shiels, C; Freemont, PS. PML protein isoforms and the RBCC/TRIM motif. Oncogene. 2001, 20 (49): 7223–33. PMID 11704850. doi:10.1038/sj.onc.1204765. 已忽略未知参数
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(帮助) - Pearson, M; Pelicci, PG. PML interaction with p53 and its role in apoptosis and replicative senescence. Oncogene. 2001, 20 (49): 7250–6. PMID 11704853. doi:10.1038/sj.onc.1204856. 已忽略未知参数
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(帮助) - Salomoni, P; Pandolfi, PP. The role of PML in tumor suppression. Cell. 2002, 108 (2): 165–70. PMID 11832207. doi:10.1016/S0092-8674(02)00626-8. 已忽略未知参数
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(帮助) - Combes, R; Balls, M; Bansil, L; Barratt, M; Bell, D; Botham, P; et al. An assessment of progress in the use of alternatives in toxicity testing since the publication of the report of the second FRAME Toxicity Committee (1991). Alternatives to laboratory animals : ATLA. 2002, 30 (4): 365–406. PMID 12234245. 已忽略未知参数
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(帮助) - Bernardi, R; Pandolfi, PP. Role of PML and the PML-nuclear body in the control of programmed cell death. Oncogene. 2004, 22 (56): 9048–57. PMID 14663483. doi:10.1038/sj.onc.1207106. 已忽略未知参数
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(帮助) - Beez, S; Demmer, P; Puccetti, E. Targeting the Acute Promyelocytic Leukemia-Associated Fusion Proteins PML/RARα and PLZF/RARα with Interfering Peptides. PLOS ONE. 2012, 7 (11): e48636. PMC 3494703 . PMID 23152790. doi:10.1371/journal.pone.0048636. 已忽略未知参数
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