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A2780

维基百科,自由的百科全书

A2780是分離於未接受任何治療的人類女性卵巢癌患者上皮性卵巢細胞系[1],因對基質膜的粘附能力弱而具有強烈的遷移侵襲能力,故而惡性程度高。卵巢癌特異性結合 (OSTP) 對A2780細胞具有特異結合作用[2]。有研究指出新藤黃酸能誘導A2780細胞發生線粒體的凋亡,並且抑制細胞的生長及增殖[3]。同時又有研究指出敲除CKS2英语CKS2能夠抑制A2780細胞中CDC42-V1 mRNA的表達,同時增強CDC42-V2 mRNA的表達,從而抑制絲足英语Filopodia的形成及細胞的遷移能力[4]

參考資料

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  1. ^ Janczar, S; Graham, JS; Paige, AJW; Gabra, H. Targeting locoregional peritoneal dissemination in ovarian cancer. Expert Review of Obstetrics & Gynecology. 2014-01-10, 4 (2): 133–147. doi:10.1586/17474108.4.2.133. 
  2. ^ Yang, C; He, X; Liu, X; Tang, Z; Liang, X. OSTP as a novel peptide specifically targeting human ovarian cancer.. Oncology reports. 2015-08, 34 (2): 972–8 [2019-12-07]. PMID 26081347. doi:10.3892/or.2015.4066. 
  3. ^ CHENG Hui; LI Qing-lin; HOU Mei; SU Jing-jing. Effect of Gambogenic Acid on the Apoptosis of Ovarian Cancer Cell Line A2780. Journal of Anhui University of Chinese Medicine. 2019, (1): 58–62 [2019-12-07]. doi:10.3969/j.isn.2095-7246.2019.01.016. (原始内容存档于2019-12-07). 
  4. ^ Qian-ling, SUN; Meng-meng, DONG; YI, Yi; Jin-hui, HU; Mi-ni, ZHANG. Alternate title: CKS2 affects filopodia formation of A2780 cells through regulating CDC42 alternative splicing. Jie Fang Jun Yi Xue Za Zhi. 2016, 41 (8): 618–623. doi:10.11855/j.issn.0577-7402.2016.08.02. 

外部連結

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