醋哌隆
外观
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临床资料 | |
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其他名称 | Acetabuton、R 3248 |
ATC码 |
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识别信息 | |
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CAS号 | 807-31-8 |
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CompTox Dashboard (EPA) | |
化学信息 | |
化学式 | C24H29FN2O2 |
摩尔质量 | 396.51 g·mol−1 |
3D模型(JSmol) | |
熔点 | 97至100 °C(207至212 °F) [1] |
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醋哌隆(INN:aceperone)是丁酰苯类的精神安定药。它是杨森制药于1960年代开发的一种α-去甲肾上腺素阻断药物。[1]
醋哌隆已被用作学习生化基础研究的工具。尽管醋哌隆本身不会阻碍学习,但在低于影响一般行为的剂量下,它会阻碍动物的一种注意力机制,该机制在学习视觉判别任务时帮助动物“调谐”到相关的视觉维度。[2][3][4]
参考资料
[编辑]- ^ 1.0 1.1 BE 606849,Janssen PA,“Alkoxylamino and alkoxycarbonylamino derivatives of 1(aroylalkyl)-4-arylpiperidines.”,发表于1961
- ^ Ridley RM, Haystead TA, Baker HF, Crow TJ. A new approach to the role of noradrenaline in learning: problem-solving in the marmoset after alpha-noradrenergic receptor blockade. Pharmacology, Biochemistry, and Behavior. June 1981, 14 (6): 849–55. PMID 6114497. S2CID 35341802. doi:10.1016/0091-3057(81)90373-7.
- ^ Baker HF, Ridley RM, Haystead TA, Crow TJ. Further consideration of the learning impairment after aceperone in the marmoset: effects of the drug on shape and colour discrimination and on an alternation task. Pharmacology, Biochemistry, and Behavior. May 1983, 18 (5): 701–4. PMID 6222386. S2CID 7905046. doi:10.1016/0091-3057(83)90009-6.
- ^ Scraggs PR, Ridley RM. The effect of dopamine and noradrenaline blockade on amphetamine-induced behaviour in the marmoset. Psychopharmacology. March 1979, 62 (1): 41–5. PMID 155838. S2CID 38197514. doi:10.1007/BF00426033.
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