DEDD

DEDD
識別號
別名	DEDD；, CASP8IP1, DEDD1, DEFT, FLDED1, KE05, death effector domain containing
外部ID	OMIM：606841 MGI：1333874 HomoloGene：7980 GeneCards：DEDD
基因位置（人類）
染色體	1號染色體
終止	161,132,688 bp
基因位置（小鼠）
染色體	小鼠1號染色體
終止	171,169,899 bp
RNA表達模式
	; ; ; ;
	查閱更多表達數據
基因本體
分子功能	• 血漿蛋白結合; • DNA結合;
細胞組分	• 細胞質; • 細胞核; • 核仁;
生物學過程	• regulation of apoptotic process; • regulation of transcription, DNA-templated; • transcription, DNA-templated; • 細胞凋亡; • 精子發生; • extrinsic apoptotic signaling pathway via death domain receptors; • negative regulation of protein catabolic process; • 蛻膜化; • negative regulation of transcription of nucleolar large rRNA by RNA polymerase I;
	Sources:Amigo / QuickGO
直系同源
	9191
	21945
	ENSG00000158796
	ENSMUSG00000013973
	O75618
	Q9Z1L3
	NM_001039711; NM_001039712; NM_004216; NM_032998; NM_001330765
NM_001128609; NM_011615; NM_001357550; NM_001357551; NM_001357552;
	NM_001357553
	NP_001034800; NP_001034801; NP_001317694; NP_127491
NP_001122081; NP_035745; NP_001344479; NP_001344480; NP_001344481;
	NP_001344482
	維基數據
檢視/編輯人類	檢視/編輯小鼠

含死亡效應結構域蛋白（英語：Death effector domain containing protein）是人類中由DEDD基因編碼的蛋白質。^[5]^[6]^[7]

功能[編輯]

該基因編碼含有死亡效應結構域（DED）的蛋白質。DED是程式性細胞死亡途徑的銜接子、調節子和執行子共享的蛋白質相互作用域。該基因的過度表達被證明可誘導微弱的細胞凋亡。在刺激作用下，發現該蛋白從細胞質易位到細胞核，並與UBTF共定位在核仁中，UBTF是RNA聚合酶I轉錄所需的基礎因子。該基因至少有三種編碼相同蛋白質的轉錄變體。^[8]

相互作用[編輯]

DEDD已被證明可以與以下基因產生相互作用：

參考資料[編輯]

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000158796 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000013973 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^5.0 ^5.1 Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. Dec 1998, 17 (20): 5974–86. PMC 1170924 . PMID 9774341. doi:10.1093/emboj/17.20.5974.
^ Leo CP, Hsu SY, McGee EA, Salanova M, Hsueh AJ. DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells. Endocrinology. Dec 1998, 139 (12): 4839–48. PMID 9832420. doi:10.1210/endo.139.12.6335 .
^ Entrez Gene: DEDD death effector domain containing.
^ 引用錯誤：沒有為名為entrez2的參考文獻提供內容
^ ^9.0 ^9.1 Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. Cell Death Differ. Apr 2002, 9 (4): 439–47. PMID 11965497. doi:10.1038/sj.cdd.4401038 .
^ ^10.0 ^10.1 Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC. Identification and characterization of DEDD2, a death effector domain-containing protein. J. Biol. Chem. Mar 2002, 277 (9): 7501–8. PMID 11741985. doi:10.1074/jbc.M110749200 .
^ Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. Oct 1998, 17 (20): 5974–86. PMC 1170924 . PMID 9774341. doi:10.1093/emboj/17.20.5974.
^ Alcivar A, Hu S, Tang J, Yang X. DEDD and DEDD2 associate with caspase-8/10 and signal cell death. Oncogene. Jan 2003, 22 (2): 291–7. PMID 12527898. doi:10.1038/sj.onc.1206099 .

延伸閱讀[編輯]

Park MY, Ryu SW, Kim KD, Lim JS, Lee ZW, Kim E. Fas-associated factor-1 mediates chemotherapeutic-induced apoptosis via death effector filament formation. Int. J. Cancer. 2005, 115 (3): 412–8. PMID 15688372. doi:10.1002/ijc.20857 .
Alcivar A, Hu S, Tang J, Yang X. DEDD and DEDD2 associate with caspase-8/10 and signal cell death. Oncogene. 2003, 22 (2): 291–7. PMID 12527898. doi:10.1038/sj.onc.1206099 .
Lee JC, Schickling O, Stegh AH, Oshima RG, Dinsdale D, Cohen GM, Peter ME. DEDD regulates degradation of intermediate filaments during apoptosis. J. Cell Biol. 2002, 158 (6): 1051–66. PMC 2173221 . PMID 12235123. doi:10.1083/jcb.200112124.
Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. Cell Death Differ. 2002, 9 (4): 439–47. PMID 11965497. doi:10.1038/sj.cdd.4401038 .
Schickling O, Stegh AH, Byrd J, Peter ME. Nuclear localization of DEDD leads to caspase-6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription. Cell Death Differ. 2002, 8 (12): 1157–68. PMID 11753564. doi:10.1038/sj.cdd.4400928 .
Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC. Identification and characterization of DEDD2, a death effector domain-containing protein. J. Biol. Chem. 2002, 277 (9): 7501–8. PMID 11741985. doi:10.1074/jbc.M110749200 .

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000158796 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000013973 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9774341-5] 5.0 ^5.1 Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. Dec 1998, 17 (20): 5974–86. PMC 1170924 . PMID 9774341. doi:10.1093/emboj/17.20.5974.

[pmid9832420-6] Leo CP, Hsu SY, McGee EA, Salanova M, Hsueh AJ. DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells. Endocrinology. Dec 1998, 139 (12): 4839–48. PMID 9832420. doi:10.1210/endo.139.12.6335 .

[entrez-7] Entrez Gene: DEDD death effector domain containing.

[entrez2-8] 引用錯誤：沒有為名為entrez2的參考文獻提供內容

[pmid11965497-9] 9.0 ^9.1 Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. Cell Death Differ. Apr 2002, 9 (4): 439–47. PMID 11965497. doi:10.1038/sj.cdd.4401038 .

[pmid11741985-10] 10.0 ^10.1 Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC. Identification and characterization of DEDD2, a death effector domain-containing protein. J. Biol. Chem. Mar 2002, 277 (9): 7501–8. PMID 11741985. doi:10.1074/jbc.M110749200 .

[autogenerated1-11] Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. EMBO J. Oct 1998, 17 (20): 5974–86. PMC 1170924 . PMID 9774341. doi:10.1093/emboj/17.20.5974.

[pmid12527898-12] Alcivar A, Hu S, Tang J, Yang X. DEDD and DEDD2 associate with caspase-8/10 and signal cell death. Oncogene. Jan 2003, 22 (2): 291–7. PMID 12527898. doi:10.1038/sj.onc.1206099 .

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