訶黎勒酸
外觀
訶黎勒酸 | |
---|---|
![]() | |
識別 | |
CAS號 | 23094-71-5 ![]() |
PubChem | 442674 |
SMILES |
|
InChI |
|
InChIKey | HGJXAVROWQLCTP-YABCKIEDSA-N |
性質 | |
化學式 | C41H30O27 |
摩爾質量 | 954.66 g/mol g·mol⁻¹ |
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。 |
訶黎勒酸是一種苯並吡喃鞣質和抗氧化劑,在醫學上有許多潛在用途。
來源
[編輯]訶黎勒酸存在於欖仁屬的訶子、黃訶子、欖仁樹等植物中,[1]可以由老鸛草素通過穀胱甘肽的介導形成。[2]
應用
[編輯]訶黎勒酸可以應用於免疫抑制、[3]護肝等方面[4],以及作為一種強效α-葡萄糖苷酶抑制劑[5][6]。
訶黎勒酸對金黃色葡萄球菌和白色念珠菌有很強的殺滅作用。[7]
參考資料
[編輯]- ^ Chemopreventive effect of punicalagin, a novel tannin component isolated from Terminalia catappa, on H-ras-transformed NIH3T3 cells. Pin-Shern Chen and Jih-Heng Li, Toxicology Letters, Volume 163, Issue 1, 5 May 2006, Pages 44-53
- ^ Glutathione-mediated conversion of the ellagitannin geraniin into chebulagic acid. Tanaka T, Kouno I and Nonaka G.I, Chemical and pharmaceutical bulletin, 1996, volume 44, no 1, pages 34-40, INIST:3003361
- ^ HAMADA, Shin-ichi; KATAOKA, Takao; WOO, Je-Tae; YAMADA, Atsushi; YOSHIDA, Takashi; NISHIMURA, Toshio; OTAKE, Noboru; NAGAI, Kazuo. Immunosuppressive Effects of Gallic Acid and Chebulagic Acid on CTL-Mediated Cytotoxicity.. Biological & Pharmaceutical Bulletin. 1997, 20 (9): 1017–1019. PMID 9331989. doi:10.1248/bpb.20.1017.
- ^ Kinoshita, S.; Inoue, Y.; Nakama, S.; Ichiba, T.; Aniya, Y. Antioxidant and hepatoprotective actions of medicinal herb, Terminalia catappa L. from Okinawa Island and its tannin corilagin. Phytomedicine. November 2007, 14 (11): 755–762. PMID 17293097. doi:10.1016/j.phymed.2006.12.012.
- ^ Sasidharan, I; Sundaresan, A; Nisha, VM; Kirishna, MS; Raghu, KG; Jayamurthy, P. Inhibitory effect of Terminalia chebula Retz. fruit extracts on digestive enzyme related to diabetes and oxidative stress. J Enzyme Inhib Med Chem. 2012, 27 (4): 578–86. PMID 22512724. doi:10.3109/14756366.2011.603130.
- ^ Pham, AT; Malterud, KE; Paulsen, BS; Diallo, D; Wangensteen, H. α-Glucosidase inhibition, 15-lipoxygenase inhibition, and brine shrimp toxicity of extracts and isolated compounds from Terminalia macroptera leaves. Pharm Biol. 2014, 52 (9): 1166–9. PMID 24635511. doi:10.3109/13880209.2014.880486.
- ^ Archived copy. [2008-10-25]. (原始內容存檔於2008-12-06).
|