EID1

EP300 相互作用分化抑制因子1
EP300 interacting inhibitor of differentiation 1
EP300 相互作用分化抑制因子1; EP300 interacting inhibitor of differentiation 1
标识
代号	EID1; C15orf3; CRI1; EID-1; IRO45620; PTD014; RBP21
扩展标识	遗传学：605894 鼠基因：1889651 同源基因：49376 GeneCards: EID1 Gene
基因本体论描述
分子功能	· transcription corepressor activity; · protein binding; · histone acetyltransferase regulator activity; · histone acetyltransferase binding;
细胞成分	· nucleus; · cytoplasm;
生物过程	· negative regulation of transcription from RNA polymerase II promoter; · transcription, DNA-dependent; · cell cycle; · cell differentiation; · regulation of histone acetylation; · negative regulation of transcription, DNA-dependent;
	Sources: Amigo / QuickGO
直系同源体
物种	人类
Entrez	23741
Ensembl	ENSG00000255302
UniProt	Q9Y6B2
mRNA序列	NM_014335
蛋白序列	NP_055150
基因位置	Chr 15:; 49.17 – 49.17 Mb
PubMed查询	[1]
	查; 论; 编;

EP300相互作用分化抑制因子1（英语：EP300-interacting inhibitor of differentiation 1）是一种由人类基因 EID1 编码的蛋白质^[1]^[2]^[3]。

相互作用

EID1已知能与EP300^[2]^[4]或视网膜母细胞瘤蛋白^[2]^[4]相互作用。

参考文献

^ Carim L, Sumoy L, Andreu N, Estivill X, Escarceller M. Identification and expression analysis of C15orf3, a novel gene on chromosome 15q21.1→q21.2. Cytogenet Cell Genet. June 2000, 88 (3-4): 330–2. PMID 10828624. doi:10.1159/000015523.
^ ^2.0 ^2.1 ^2.2 MacLellan WR, Xiao G, Abdellatif M, Schneider MD. A novel Rb- and p300-binding protein inhibits transactivation by MyoD. Mol Cell Biol. December 2000, 20 (23): 8903–15. PMC 86545 . PMID 11073990. doi:10.1128/MCB.20.23.8903-8915.2000.
^ Entrez Gene: EID1 EP300 interacting inhibitor of differentiation 1. （原始内容存档于2019-10-16）.
^ ^4.0 ^4.1 Miyake, S; Sellers W R, Safran M, Li X, Zhao W, Grossman S R, Gan J, DeCaprio J A, Adams P D, Kaelin W G. Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle. Mol. Cell. Biol. (UNITED STATES). December 2000, 20 (23): 8889–902. ISSN 0270-7306. PMC 86544 . PMID 11073989. doi:10.1128/MCB.20.23.8889-8902.2000.

延伸阅读

Ghosh AK, Varga J. The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosis.. J. Cell. Physiol. 2007, 213 (3): 663–71. PMID 17559085. doi:10.1002/jcp.21162.
Margottin F, Bour SP, Durand H; et al. A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif.. Mol. Cell. 1998, 1 (4): 565–74. PMID 9660940. doi:10.1016/S1097-2765(00)80056-8.
Miyake S, Sellers WR, Safran M; et al. Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle.. Mol. Cell. Biol. 2000, 20 (23): 8889–902. PMC 86544 . PMID 11073989. doi:10.1128/MCB.20.23.8889-8902.2000.
Wen H, Ao S. Identification and characterization of a novel human cDNA encoding a 21 kDa pRb-associated protein.. Gene. 2001, 263 (1-2): 85–92. PMID 11223246. doi:10.1016/S0378-1119(00)00585-0.
Båvner A, Johansson L, Toresson G; et al. A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP.. EMBO Rep. 2002, 3 (5): 478–84. PMC 1084100 . PMID 11964378. doi:10.1093/embo-reports/kvf087.
Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ledl A, Schmidt D, Müller S. Viral oncoproteins E1A and E7 and cellular LxCxE proteins repress SUMO modification of the retinoblastoma tumor suppressor.. Oncogene. 2005, 24 (23): 3810–8. PMID 15806172. doi:10.1038/sj.onc.1208539.
Krützfeldt M, Ellis M, Weekes DB; et al. Selective ablation of retinoblastoma protein function by the RET finger protein.. Mol. Cell. 2005, 18 (2): 213–24. PMID 15837424. doi:10.1016/j.molcel.2005.03.009.
Benevolenskaya EV, Murray HL, Branton P; et al. Binding of pRB to the PHD protein RBP2 promotes cellular differentiation.. Mol. Cell. 2005, 18 (6): 623–35. PMID 15949438. doi:10.1016/j.molcel.2005.05.012.
Rual JF, Venkatesan K, Hao T; et al. Towards a proteome-scale map of the human protein-protein interaction network.. Nature. 2005, 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.

[pmid10828624-1] Carim L, Sumoy L, Andreu N, Estivill X, Escarceller M. Identification and expression analysis of C15orf3, a novel gene on chromosome 15q21.1→q21.2. Cytogenet Cell Genet. June 2000, 88 (3-4): 330–2. PMID 10828624. doi:10.1159/000015523.

[pmid11073990-2] 2.0 ^2.1 ^2.2 MacLellan WR, Xiao G, Abdellatif M, Schneider MD. A novel Rb- and p300-binding protein inhibits transactivation by MyoD. Mol Cell Biol. December 2000, 20 (23): 8903–15. PMC 86545 . PMID 11073990. doi:10.1128/MCB.20.23.8903-8915.2000.

[entrez-3] Entrez Gene: EID1 EP300 interacting inhibitor of differentiation 1. （原始内容存档于2019-10-16）.

[pmid11073989-4] 4.0 ^4.1 Miyake, S; Sellers W R, Safran M, Li X, Zhao W, Grossman S R, Gan J, DeCaprio J A, Adams P D, Kaelin W G. Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle. Mol. Cell. Biol. (UNITED STATES). December 2000, 20 (23): 8889–902. ISSN 0270-7306. PMC 86544 . PMID 11073989. doi:10.1128/MCB.20.23.8889-8902.2000.

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