右啡烷

右啡烷
临床资料
其他名称	DXO, Dextrorphanol
ATC码	未分配;
法律规范状态
法律规范	美：Unscheduled;
识别信息
	IUPAC命名法 (+)-17-methyl-9a,13a,14a-morphinan-3-ol; ;
CAS号	125-73-5
PubChem CID	5360697;
ChemSpider	10489895 ;
UNII	04B7QNO9WS;
ChEMBL	ChEMBL1254766 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID301014178 ;
ECHA InfoCard	100.004.323
化学信息
化学式	C17H23NO
摩尔质量	257.38 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES CN1CC[C@@]23CCCC[C@@H]2[C@@H]1Cc4c3cc(O)cc4;
	InChI InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m1/s1 ; Key:JAQUASYNZVUNQP-PVAVHDDUSA-N ;

右啡烷（Dextrorphan，DXO）是一种吗啡类的精神药物，具有镇咳与止咳，或作为解离性致幻剂的作用，也是外消旋吗汎（英语：Racemorphan）的右旋对映体，另一个左旋对映体则是左旋吗汎（英语：Levorphanol）。右啡烷是右美沙芬由CYP2D6酶经O-脱甲基（O-demethylated）而生成的，作为一种NMDA拮抗剂，右啡烷可产生右美沙芬所带来的精神效应。^[2]

药理学

药效学

右啡烷^[3]^[4]^[5]^[6]
位置	K_i (nM)	对象	引用
NMDAR (MK-801)	486–906	鼠	^[4]
σ₁	118–481	鼠	^[4]
σ₂	11,325–15,582	鼠	^[4]
MOR	420 >1,000	鼠人	^[4]^[7]
DOR	34,700	鼠	^[4]
KOR	5,950	鼠	^[4]
SERT	401–484	鼠	^[4]
NET	≥340	鼠	^[4]
DAT	>1,000	鼠	^[4]
5-HT_1A	>1,000	鼠	^[4]
5-HT_1B_/_1D	54% at 1 μM	鼠	^[4]
5-HT_2A	>1,000	鼠	^[4]
α₁	>1,000	鼠	^[4]
α₂	>1,000	鼠	^[4]
β	35% at 1 μM	鼠	^[4]
D₂	>1,000	鼠	^[4]
H₁	95% at 1 μM	鼠	^[4]
mAChRs	100% at 1 μM	鼠	^[4]
nAChRs	1,300–29,600 (IC₅₀)	鼠	^[4]
VDSCs	ND	ND	ND
除非另加说明，否则以上所示数值均为K_i(nM)。数值越小，说明药物与该位点的结合力越强。

右啡烷的药理作用类似于右美沙芬。不过，右啡烷作为NMDA受体拮抗剂的效力要强得多，作为SRI的活性也低得多。不过右啡烷仍保留了右美沙芬作为NRIs时的活性。^[8]并且其对阿片受体的亲和力也较右美沙芬强，且高剂量下更强。

药代动力学

右啡烷的生物半衰期长于其母体化合物，因此在重复服用正常剂量的右美沙芬制剂后容易在血液中蓄积。其还会被CYP3A4进一步转化为3-羟基吗啡喃或被葡萄糖醛酸化（英语：Glucuronidation）。^[9]

研究

右啡烷曾被开发用于治疗中风，也已进行了II期临床试验，但开发工作已经中止。^[10]

参考文献

^ Bensinger, Peter. Dextrophan and Nalbuphine; Removal from Schedules (PDF). NARA. October 1, 1976 [June 26, 2023]. （原始内容存档 (PDF)于2023-06-27）.
^ Zawertailo LA, Kaplan HL, Busto UE, Tyndale RF, Sellers EM. Psychotropic effects of dextromethorphan are altered by the CYP2D6 polymorphism: a pilot study. Journal of Clinical Psychopharmacology. August 1998, 18 (4): 332–337. PMID 9690700. doi:10.1097/00004714-199808000-00014.
^ Roth BL, Driscol J. PDSP K_i Database. Psychoactive Drug Screening Program (PDSP). University of North Carolina at Chapel Hill and the United States National Institute of Mental Health. [14 August 2017]. （原始内容存档于2023-01-01）.
^ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 ^4.17 ^4.18 ^4.19 Nguyen L, Thomas KL, Lucke-Wold BP, Cavendish JZ, Crowe MS, Matsumoto RR. Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders. Pharmacol. Ther. 2016, 159: 1–22. PMID 26826604. doi:10.1016/j.pharmthera.2016.01.016.
^ Werling LL, Keller A, Frank JG, Nuwayhid SJ. A comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: treatment of involuntary emotional expression disorder. Exp. Neurol. 2007, 207 (2): 248–57. PMID 17689532. S2CID 38476281. doi:10.1016/j.expneurol.2007.06.013.
^ Taylor CP, Traynelis SF, Siffert J, Pope LE, Matsumoto RR. Pharmacology of dextromethorphan: Relevance to dextromethorphan/quinidine (Nuedexta®) clinical use. Pharmacol. Ther. 2016, 164: 170–82. PMID 27139517. doi:10.1016/j.pharmthera.2016.04.010 .
^ Raynor K, Kong H, Mestek A, Bye LS, Tian M, Liu J, Yu L, Reisine T. Characterization of the cloned 人 mu opioid receptor. J. Pharmacol. Exp. Ther. 1995, 272 (1): 423–8. PMID 7815359.
^ Pechnick RN, Poland RE. Comparison of the effects of dextromethorphan, dextrorphan, and levorphanol on the hypothalamo-pituitary-adrenal axis. The Journal of Pharmacology and Experimental Therapeutics. May 2004, 309 (2): 515–522. PMID 14742749. S2CID 274504. doi:10.1124/jpet.103.060038.
^ Yu A, Haining RL. Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities?. Drug Metabolism and Disposition. November 2001, 29 (11): 1514–20 [2023-10-01]. PMID 11602530. （原始内容存档于2020-03-12）.
^ Dextrorphan - AdisInsight. [2023-10-01]. （原始内容存档于2021-07-05）.

[1] Bensinger, Peter. Dextrophan and Nalbuphine; Removal from Schedules (PDF). NARA. October 1, 1976 [June 26, 2023]. （原始内容存档 (PDF)于2023-06-27）.

[2] Zawertailo LA, Kaplan HL, Busto UE, Tyndale RF, Sellers EM. Psychotropic effects of dextromethorphan are altered by the CYP2D6 polymorphism: a pilot study. Journal of Clinical Psychopharmacology. August 1998, 18 (4): 332–337. PMID 9690700. doi:10.1097/00004714-199808000-00014.

[PDSP-3] Roth BL, Driscol J. PDSP K_i Database. Psychoactive Drug Screening Program (PDSP). University of North Carolina at Chapel Hill and the United States National Institute of Mental Health. [14 August 2017]. （原始内容存档于2023-01-01）.

[pmid26826604-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 ^4.15 ^4.16 ^4.17 ^4.18 ^4.19 Nguyen L, Thomas KL, Lucke-Wold BP, Cavendish JZ, Crowe MS, Matsumoto RR. Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders. Pharmacol. Ther. 2016, 159: 1–22. PMID 26826604. doi:10.1016/j.pharmthera.2016.01.016.

[pmid17689532-5] Werling LL, Keller A, Frank JG, Nuwayhid SJ. A comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: treatment of involuntary emotional expression disorder. Exp. Neurol. 2007, 207 (2): 248–57. PMID 17689532. S2CID 38476281. doi:10.1016/j.expneurol.2007.06.013.

[pmid27139517-6] Taylor CP, Traynelis SF, Siffert J, Pope LE, Matsumoto RR. Pharmacology of dextromethorphan: Relevance to dextromethorphan/quinidine (Nuedexta®) clinical use. Pharmacol. Ther. 2016, 164: 170–82. PMID 27139517. doi:10.1016/j.pharmthera.2016.04.010 .

[pmid7815359-7] Raynor K, Kong H, Mestek A, Bye LS, Tian M, Liu J, Yu L, Reisine T. Characterization of the cloned 人 mu opioid receptor. J. Pharmacol. Exp. Ther. 1995, 272 (1): 423–8. PMID 7815359.

[8] Pechnick RN, Poland RE. Comparison of the effects of dextromethorphan, dextrorphan, and levorphanol on the hypothalamo-pituitary-adrenal axis. The Journal of Pharmacology and Experimental Therapeutics. May 2004, 309 (2): 515–522. PMID 14742749. S2CID 274504. doi:10.1124/jpet.103.060038.

[DXMdualprobe-9] Yu A, Haining RL. Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities?. Drug Metabolism and Disposition. November 2001, 29 (11): 1514–20 [2023-10-01]. PMID 11602530. （原始内容存档于2020-03-12）.

[AdisInsight-10] Dextrorphan - AdisInsight. [2023-10-01]. （原始内容存档于2021-07-05）.

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