醇脱氢酶4

Alcohol dehydrogenase 4 (class II), pi polypeptide
Alcohol dehydrogenase 4 (class II), pi polypeptide
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	3COS
标识
代号	ADH4; ADH-2; HEL-S-4
扩展标识	遗传学：103740 鼠基因：1349472 同源基因：20162 ChEMBL: 2990 GeneCards: ADH4 Gene
EC编号	1.1.1.1
基因本体论描述
分子功能	· NADPH:quinone reductase activity; · alcohol dehydrogenase (NAD) activity; · alcohol dehydrogenase activity, zinc-dependent; · alditol:NADP+ 1-oxidoreductase activity; · retinol dehydrogenase activity; · all-trans retinal binding; · zinc ion binding; · oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; · benzaldehyde dehydrogenase activity; · retinol binding; · ethanol binding; · NAD binding;
细胞成分	· cytosol;
生物过程	· retinoid metabolic process; · alcohol metabolic process; · ethanol oxidation; · cellular aldehyde metabolic process; · xenobiotic metabolic process; · retinol metabolic process; · small molecule metabolic process; · alcohol catabolic process; · quinone metabolic process;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	127
Ensembl	ENSG00000198099
UniProt	P08319
mRNA序列	NM_000670
蛋白序列	NP_000661
基因位置	Chr 4:; 100.04 – 100.08 Mb
PubMed查询	[1]
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醇脱氢酶4（英语：Alcohol dehydrogenase 4）是由人类基因 ADH4 编码的蛋白质^[1]。

ADH4编码醇脱氢酶家族中的第II类醇脱氢酶4π亚基。这一类脱氢酶可以催化许多底物，包括乙醇、视黄醇以及其它脂肪醇、羟类固醇（英语：hydroxysteroids）和脂质过氧化产物。第II类醇脱氢酶由两个π亚基同聚形成，对氧化长链脂肪醇和芳香醇有很高的活性，并对吡唑不敏感。这一基因存在于人4号染色体醇脱氢酶基因簇中^[1]。

参考文献

^ ^1.0 ^1.1 Entrez Gene: ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide. （原始内容存档于2009-05-11）.

延伸阅读

Jörnvall H. The alcohol dehydrogenase system.. EXS. 1994, 71: 221–9. PMID 8032153. doi:10.1007/978-3-0348-7330-7_22.
Edman K, Maret W. Alcohol dehydrogenase genes: restriction fragment length polymorphisms for ADH4 (pi-ADH) and ADH5 (chi-ADH) and construction of haplotypes among different ADH classes.. Hum. Genet. 1993, 90 (4): 395–401. PMID 1362387. doi:10.1007/bf00220466.
von Bahr-Lindström H, Jörnvall H, Höög JO. Cloning and characterization of the human ADH4 gene.. Gene. 1991, 103 (2): 269–74. PMID 1889753. doi:10.1016/0378-1119(91)90285-J.
Höög JO, von Bahr-Lindström H, Hedén LO; et al. Structure of the class II enzyme of human liver alcohol dehydrogenase: combined cDNA and protein sequence determination of the pi subunit.. Biochemistry. 1987, 26 (7): 1926–32. PMID 3036213. doi:10.1021/bi00381a021.
Mårdh G, Dingley AL, Auld DS, Vallee BL. Human class II (pi) alcohol dehydrogenase has a redox-specific function in norepinephrine metabolism.. Proc. Natl. Acad. Sci. U.S.A. 1987, 83 (23): 8908–12. PMC 387042 . PMID 3466164. doi:10.1073/pnas.83.23.8908.
Li M, Edenberg HJ. Function of cis-acting elements in human alcohol dehydrogenase 4 (ADH4) promoter and role of C/EBP proteins in gene expression.. DNA Cell Biol. 1998, 17 (4): 387–97. PMID 9570155. doi:10.1089/dna.1998.17.387.
Tryggvason K, Romert A, Eriksson U. Biosynthesis of 9-cis-retinoic acid in vivo. The roles of different retinol dehydrogenases and a structure-activity analysis of microsomal retinol dehydrogenases.. J. Biol. Chem. 2001, 276 (22): 19253–8. PMID 11279029. doi:10.1074/jbc.M100215200.
Xu XR, Huang J, Xu ZG; et al. Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.. Proc. Natl. Acad. Sci. U.S.A. 2002, 98 (26): 15089–94. PMC 64988 . PMID 11752456. doi:10.1073/pnas.241522398.
Iida A, Saito S, Sekine A; et al. Thirteen single-nucleotide polymorphisms (SNPs) in the alcohol dehydrogenase 4 (ADH4) gene locus.. J. Hum. Genet. 2002, 47 (2): 74–6. PMID 11916005. doi:10.1007/s100380200003.
Strömberg P, Svensson S, Hedberg JJ; et al. Identification and characterisation of two allelic forms of human alcohol dehydrogenase 2.. Cell. Mol. Life Sci. 2002, 59 (3): 552–9. PMID 11964133. doi:10.1007/s00018-002-8447-1.
Chou CF, Lai CL, Chang YC; et al. Kinetic mechanism of human class IV alcohol dehydrogenase functioning as retinol dehydrogenase.. J. Biol. Chem. 2002, 277 (28): 25209–16. PMID 11997393. doi:10.1074/jbc.M201947200.
Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Galter D, Carmine A, Buervenich S; et al. Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain.. Eur. J. Biochem. 2003, 270 (6): 1316–26. PMID 12631290. doi:10.1046/j.1432-1033.2003.03502.x.
Neumark YD, Friedlander Y, Durst R; et al. Alcohol dehydrogenase polymorphisms influence alcohol-elimination rates in a male Jewish population.. Alcohol. Clin. Exp. Res. 2004, 28 (1): 10–4. PMID 14745297. doi:10.1097/01.ALC.0000108667.79219.4D.
Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Luo X, Kranzler HR, Zuo L; et al. ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies.. Pharmacogenet. Genomics. 2006, 15 (11): 755–68. PMID 16220108. doi:10.1097/01.fpc.0000180141.77036.dc.
Luo X, Kranzler HR, Zuo L; et al. ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies.. Neuropsychopharmacology. 2006, 31 (5): 1085–95. PMID 16237392. doi:10.1038/sj.npp.1300925.
Luo X, Kranzler HR, Zuo L; et al. Personality traits of agreeableness and extraversion are associated with ADH4 variation.. Biol. Psychiatry. 2007, 61 (5): 599–608. PMC 1853245 . PMID 17069770. doi:10.1016/j.biopsych.2006.05.017.

[entrez-1] 1.0 ^1.1 Entrez Gene: ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide. （原始内容存档于2009-05-11）.

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