METTL3

METTL3
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	5IL0、5IL2、5IL1、5K7M、5K7U、5K7W
识别号
别名	METTL3；, IME4, M6A, MT-A70, Spo8, methyltransferase like 3, hmethyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
外部ID	OMIM：612472 MGI：1927165 HomoloGene：10501 GeneCards：METTL3
基因位置（人类）
染色体	14号染色体
终止	21,511,342 bp
基因位置（小鼠）
染色体	小鼠14号染色体
终止	52,542,585 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• methyltransferase activity; • 转移酶活性; • RNA binding; • RNA methyltransferase activity; • mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity; • mRNA binding; • S-adenosyl-L-methionine binding; • protein heterodimerization activity; • 血浆蛋白结合; • mRNA (N6-adenosine)-methyltransferase activity;
细胞组分	• RNA N6-methyladenosine methyltransferase complex; • 核质; • nuclear speck; • 细胞核; • 细胞质;
生物学过程	• rhythmic process; • mRNA processing; • positive regulation of cap-independent translational initiation; • stem cell population maintenance; • 甲基化; • mRNA methylation; • mRNA destabilization; • 昼夜节律; • primary miRNA processing; • adenosine to inosine editing; • RNA甲基化; • mRNA splicing, via spliceosome; • mRNA catabolic process; • forebrain radial glial cell differentiation; • cellular response to UV; • gliogenesis; • regulation of T cell differentiation; • negative regulation of Notch signaling pathway; • regulation of meiotic cell cycle; • endothelial to hematopoietic transition; • regulation of hematopoietic stem cell differentiation; • cellular response to DNA damage stimulus; • 精子发生; • 细胞分化; • dosage compensation by inactivation of X chromosome; • 核糖核酸代谢过程;
	Sources:Amigo / QuickGO
直系同源
	56339
	56335
	ENSG00000165819
	ENSMUSG00000022160
	Q86U44
	Q8C3P7
	NM_019852
	NM_019721
	NP_062826
	NP_062695
	维基数据
查看/编辑人类	查看/编辑小鼠

METTL3全称为甲基转移酶样蛋白3（methyltransferase like 3），又称N6-腺苷甲基转移酶复合体催化亚基（N6-adenosine-methyltransferase complex catalytic subunit），在人类基因组中由14号染色体上的METTL3基因编码^[5]。此蛋白为N6-腺苷甲基转移酶复合体中具甲基转移酶（英语：Methyltransferase）活性的组成蛋白，由580个氨基酸组成，大小为70kDa，包含一锌指结构域与一甲基转移酶结构域，可将S-腺苷甲硫氨酸（SAM）上的甲基转移到mRNA中的腺苷（A）上，将其甲基化成N6-甲基腺苷（m⁶A）^[5]^[6]。METTL3与另一蛋白METTL14（英语：METTL14）共同组成N6-腺苷甲基转移酶复合体的核心，但METTL14在此复合体中仅有与RNA结合和稳定结构的功能，无催化甲基化的功能。METTL3的基因表达异常与多种癌症有关，许多案例中METTL3为致癌基因，在许多癌症中表现量增加^[6]。

参考文献[编辑]

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000165819 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000022160 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^5.0 ^5.1 Entrez Gene: METTL3 methyltransferase like 3.
^ ^6.0 ^6.1 Zeng C, Huang W, Li Y, Weng H. Roles of METTL3 in cancer: mechanisms and therapeutic targeting.. J Hematol Oncol. 2020, 13 (1): 117. PMC 7457244 . PMID 32854717. doi:10.1186/s13045-020-00951-w.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000165819 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000022160 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 5.0 ^5.1 Entrez Gene: METTL3 methyltransferase like 3.

[pmid32854717-6] 6.0 ^6.1 Zeng C, Huang W, Li Y, Weng H. Roles of METTL3 in cancer: mechanisms and therapeutic targeting.. J Hematol Oncol. 2020, 13 (1): 117. PMC 7457244 . PMID 32854717. doi:10.1186/s13045-020-00951-w.

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