3-碘類甲腺質

3-碘類甲腺質
	IUPAC名; 4-[4-(2-Aminoethyl)-2-iodophenoxy]phenol
別名	T1AM
識別
CAS號	712349-95-6
PubChem	9950514
ChemSpider	8126125
SMILES	OC1=CC=C(OC2=C(I)C=C(CCN)C=C2)C=C1;
InChI	1/C14H14INO2/c15-13-9-10(7-8-16)1-6-14(13)18-12-4-2-11(17)3-5-12/h1-6,9,17H,7-8,16H2;
InChIKey	XIINYOJWNGOUPF-UHFFFAOYAJ
性質
化學式	C14H14INO2
摩爾質量	355.17 g/mol g·mol⁻¹
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

3-類甲腺質，英文：3-Iodothyronamine（T₁AM）是一種內源性類甲腺質。T₁AM是痕量胺相關受體TAAR1（TAR1, TA1）的高親和力配體，而TAAR1是一種G蛋白偶聯受體。^[1]^[2]T₁AM是迄今為止發現的最有效的內源性TAAR1激動劑。^[3]T₁AM對TAAR1的激活導致產生大量cAMP。這種影響伴隨體溫和心輸出量的下降。^[4]這種關係不是典型的內分泌系統關係，表明TAAR1活性可能不會與某些組織中的G蛋白發生偶聯，或T₁AM可能與其他受體亞型相互作用。^[3]

由於3-類甲腺質可誘導負性肌力作用並降低心輸出量，T₁AM可能是調節心臟信號通路功能的一部分。 ^[5]

參見

<i id="mwKg">O-</i>苯基-3-碘酪胺
微量胺

參考

^ Scanlan T, Suchland K, Hart M, Chiellini G, Huang Y, Kruzich P, Frascarelli S, Crossley D, Bunzow J, Ronca-Testoni S, Lin E, Hatton D, Zucchi R, Grandy D. 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nat. Med. 2004, 10 (6): 638–42. PMID 15146179. S2CID 2389946. doi:10.1038/nm1051.
^ Hart M, Suchland K, Miyakawa M, Bunzow J, Grandy D, Scanlan T. Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues. J. Med. Chem. 2006, 49 (3): 1101–12. PMID 16451074. doi:10.1021/jm0505718.
^ ^3.0 ^3.1 Wu SY, Green WL, Huang WS, Hays MT, Chopra IJ. Alternate Pathways of Thyroid Hormone Metabolism. Thyroid. 2005, 15 (8): 943–958. PMID 16131336. doi:10.1089/thy.2005.15.943.
^ New compound may act to keep thyroid activity in check. [2008-05-30]. （原始內容存檔於2021-02-27）.
^ Chiellini G, Frascarelli S, Ghelardoni S, Carnicelli V, Tobias SC, Debarber A, Brogioni S, Ronca-Testoni S, Cerbai E, Grandy DK, Scanlan TS, Zucchi R. Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function. The FASEB Journal. 2007, 21 (7): 1597–608. PMID 17284482. S2CID 14015560. doi:10.1096/fj.06-7474com.

外部連結

醫學主題詞表（MeSH）：3-iodothyronamine

Template:Phenethylamines

[1] Scanlan T, Suchland K, Hart M, Chiellini G, Huang Y, Kruzich P, Frascarelli S, Crossley D, Bunzow J, Ronca-Testoni S, Lin E, Hatton D, Zucchi R, Grandy D. 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nat. Med. 2004, 10 (6): 638–42. PMID 15146179. S2CID 2389946. doi:10.1038/nm1051.

[2] Hart M, Suchland K, Miyakawa M, Bunzow J, Grandy D, Scanlan T. Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues. J. Med. Chem. 2006, 49 (3): 1101–12. PMID 16451074. doi:10.1021/jm0505718.

[Wu-3] 3.0 ^3.1 Wu SY, Green WL, Huang WS, Hays MT, Chopra IJ. Alternate Pathways of Thyroid Hormone Metabolism. Thyroid. 2005, 15 (8): 943–958. PMID 16131336. doi:10.1089/thy.2005.15.943.

[4] New compound may act to keep thyroid activity in check. [2008-05-30]. （原始內容存檔於2021-02-27）.

[5] Chiellini G, Frascarelli S, Ghelardoni S, Carnicelli V, Tobias SC, Debarber A, Brogioni S, Ronca-Testoni S, Cerbai E, Grandy DK, Scanlan TS, Zucchi R. Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function. The FASEB Journal. 2007, 21 (7): 1597–608. PMID 17284482. S2CID 14015560. doi:10.1096/fj.06-7474com.

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