NITD008
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| 臨床資料 | |
|---|---|
| 商品名 | NITD008 |
| 識別資訊 | |
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| CAS號 | 1044589-82-3  |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| 化學資訊 | |
| 化學式 | C13H14N4O4 |
| 摩爾質量 | 290.28 g·mol−1 |
| 3D模型（JSmol） | |
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NITD008是一種抗病毒藥物，屬於腺苷類似物（一種核苷類似物）。它作為治療黃病毒感染的潛在藥物被開發，並顯示出對很多相關病毒的廣譜活性，如骨痛熱症病毒、西尼羅河病毒、黃熱病病毒、波瓦桑病毒、C肝病毒、克亞薩努爾森林病病毒、鄂木斯克出血熱病毒和茲卡病毒。[1][2][3]然而，雖然NITD008在臨床前的動物試驗中顯示出較大毒性，不適合人體試驗，但是它仍被用於新型病毒性疾病治療的研究中。[4]
參考文獻[編輯]
- ^ Yin Z, Chen YL, Schul W, Wang QY, Gu F, Duraiswamy J, et al. An adenosine nucleoside inhibitor of dengue virus. Proceedings of the National Academy of Sciences of the United States of America. December 2009, 106 (48): 20435–9. Bibcode:2009PNAS..10620435Y. PMC 2787148
. PMID 19918064. doi:10.1073/pnas.0907010106 .
- ^ Lo MK, Shi PY, Chen YL, Flint M, Spiropoulou CF. In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses. Antiviral Research. June 2016, 130: 46–9. PMC 5096641 . PMID 27016316. doi:10.1016/j.antiviral.2016.03.013.
- ^ Deng YQ, Zhang NN, Li CF, Tian M, Hao JN, Xie XP, et al. Adenosine Analog NITD008 Is a Potent Inhibitor of Zika Virus. Open Forum Infectious Diseases. October 2016, 3 (4): ofw175. PMC 5063548 . PMID 27747251. doi:10.1093/ofid/ofw175 .
- ^ Nelson J, Roe K, Orillo B, Shi PY, Verma S. Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection. Antiviral Research. October 2015, 122: 39–45. PMC 4853296 . PMID 26225754. doi:10.1016/j.antiviral.2015.07.008.
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