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儿茶酚-O-甲基转移酶抑制药

维基百科,自由的百科全书

兒茶酚-O-甲基轉移酶抑制劑COMT抑制劑(英語: Catechol-O-methyl transferase inhibitorCOMT inhibitor)是抑制儿茶酚-O-甲基转移酶的藥物。這個酶參與神经递质的降解。COMT抑制劑用於治療帕金森氏症

一些製劑:恩他卡朋,[1] tolcapone英语tolcapone,[2] opicapone英语opicapone 以及 nitecapone英语nitecapone

参考资料

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  1. ^ Nissinen E; Nissinen H; Larjonmaa H; et al. The COMT inhibitor, entacapone, reduces levodopa-induced elevations in plasma homocysteine in healthy adult rats. J Neural Transm. September 2005, 112 (9): 1213–1221. PMID 15614425. doi:10.1007/s00702-004-0262-4. 
  2. ^ Giakoumaki SG, Roussos P, Bitsios P. Improvement of Prepulse Inhibition and Executive Function by the COMT Inhibitor Tolcapone Depends on COMT Val158Met Polymorphism. Neuropsychopharmacology. June 2008, 33 (13): 3058–3068. PMID 18536698. doi:10.1038/npp.2008.82.