LAMA1

LAMA1
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	2JD4
識別號
别名	LAMA1；, LAMA, S-LAM-alpha, PTBHS, Laminin, alpha 1, laminin subunit alpha 1
外部ID	OMIM：150320 MGI：99892 HomoloGene：21146 GeneCards：LAMA1
相關疾病
	2型糖尿病、ataxia-intellectual disability-oculomotor apraxia-cerebellar cysts syndrome
為以下藥物的標靶
	ocriplasmin
基因位置（人类）
染色体	18號染色體
终止	7,117,797 bp
基因位置（小鼠）
染色体	小鼠17号染色体
终止	68,129,642 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本體
分子功能	• signaling receptor binding; • extracellular matrix structural constituent; • 血浆蛋白结合; • protein C-terminus binding; • glycosphingolipid binding;
細胞組分	• 细胞外间质; • 細胞外區域; • 基底膜; • laminin-1 complex; • laminin-3 complex; • 細胞外空間; • 膜; • cell-cell junction; • laminin complex; • collagen-containing extracellular matrix;
生物學過程	• cell surface receptor signaling pathway; • regulation of cell adhesion; • 細胞粘附; • extracellular matrix organization; • regulation of cell migration; • regulation of embryonic development; • morphogenesis of an epithelial sheet; • protein phosphorylation; • 组织发生; • neuron projection development; • establishment of epithelial cell apical/basal polarity; • retina development in camera-type eye; • epithelial tube branching involved in lung morphogenesis; • branching involved in salivary gland morphogenesis; • retinal blood vessel morphogenesis; • 轴突导向; • animal organ morphogenesis; • camera-type eye development; • blood vessel morphogenesis;
	Sources:Amigo / QuickGO
直系同源
	284217
	16772
	ENSG00000101680
	ENSMUSG00000032796
	P25391
	P19137
	NM_005559
	NM_008480
	NP_005550
	NP_032506
	維基數據
檢視/編輯人類	檢視/編輯小鼠

层粘连蛋白亚基α1是一个层粘连蛋白的蛋白亚基。层粘蛋白是一种组成核纤层的蛋白，在细胞核的形态维持中扮演重要角色。此蛋白質在人体内由LAMA1基因编码^[7]^[8]。

相互作用

层粘蛋白亚基α1会与FBLN2（英语：FBLN2）发生蛋白质相互作用^[9]^[10]。

参考资料

^ 與LAMA1相關的疾病；在維基數據上查看/編輯參考.
^ 對Laminin subunit alpha 1起作用的藥物；在維基數據上查看/編輯參考.
^ ^3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000101680 - Ensembl, May 2017
^ ^4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000032796 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagayoshi, T.; Mattei, M. G.; Passage, E.; Knowlton, R.; Chu, M. L.; Uitto, J. Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3. Genomics. 1989-11, 5 (4): 932–935 [2021-11-10]. ISSN 0888-7543. PMID 2591971. doi:10.1016/0888-7543(89)90136-5. （原始内容存档于2021-11-10）.
^ LAMA1 laminin subunit alpha 1 [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2021-11-10]. （原始内容存档于2021-11-10）.
^ Utani, A.; Nomizu, M.; Yamada, Y. Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences. The Journal of Biological Chemistry. 1997-01-31, 272 (5): 2814–2820 [2021-11-10]. ISSN 0021-9258. PMID 9006922. doi:10.1074/jbc.272.5.2814. （原始内容存档于2021-11-10）.
^ Talts, J. F.; Sasaki, T.; Miosge, N.; Göhring, W.; Mann, K.; Mayne, R.; Timpl, R. Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues. The Journal of Biological Chemistry. 2000-11-10, 275 (45): 35192–35199 [2021-11-10]. ISSN 0021-9258. PMID 10934193. doi:10.1074/jbc.M003261200. （原始内容存档于2022-01-21）.

拓展阅读

Haaparanta, T.; Uitto, J.; Ruoslahti, E.; Engvall, E. Molecular cloning of the cDNA encoding human laminin A chain. Matrix (Stuttgart, Germany). 1991-06, 11 (3): 151–160 [2021-11-10]. ISSN 0934-8832. PMID 1714537. doi:10.1016/s0934-8832(11)80153-8. （原始内容存档于2021-11-10）.
Nissinen, M; Vuolteenaho, R; Boot-Handford, R; Kallunki, P; Tryggvason, K. Primary structure of the human laminin A chain. Limited expression in human tissues. Biochemical Journal. 1991-06-01, 276 (2): 369–379 [2021-11-10]. ISSN 0264-6021. PMC 1151101 . PMID 2049067. doi:10.1042/bj2760369. （原始内容存档于2021-08-12）（英语）.
Taraboletti, G.; Rao, C. N.; Krutzsch, H. C.; Liotta, L. A.; Roberts, D. D. Sulfatide-binding domain of the laminin A chain. The Journal of Biological Chemistry. 1990-07-25, 265 (21): 12253–12258 [2021-11-10]. ISSN 0021-9258. PMID 2373692. （原始内容存档于2021-11-10）.
Olsen, D.; Nagayoshi, T.; Fazio, M.; Peltonen, J.; Jaakkola, S.; Sanborn, D.; Sasaki, T.; Kuivaniemi, H.; Chu, M. L. Human laminin: cloning and sequence analysis of cDNAs encoding A, B1 and B2 chains, and expression of the corresponding genes in human skin and cultured cells. Laboratory Investigation; a Journal of Technical Methods and Pathology. 1989-06, 60 (6): 772–782 [2021-11-10]. ISSN 0023-6837. PMID 2733383. （原始内容存档于2021-11-10）.
Leivo, I; Engvall, E. C3d fragment of complement interacts with laminin and binds to basement membranes of glomerulus and trophoblast.. The Journal of Cell Biology. 1986-09-01, 103 (3): 1091–1100 [2021-11-10]. ISSN 0021-9525. PMC 2114300 . PMID 3488995. doi:10.1083/jcb.103.3.1091. （原始内容存档于2022-01-21）（英语）.
Wewer, U. M.; Gerecke, D. R.; Durkin, M. E.; Kurtz, K. S.; Mattei, M. G.; Champliaud, M. F.; Burgeson, R. E.; Albrechtsen, R. Human beta 2 chain of laminin (formerly S chain): cDNA cloning, chromosomal localization, and expression in carcinomas. Genomics. 1994-11-15, 24 (2): 243–252 [2021-11-10]. ISSN 0888-7543. PMID 7698745. doi:10.1006/geno.1994.1612. （原始内容存档于2021-11-10）.
Yamada, H.; Shimizu, T.; Tanaka, T.; Campbell, K. P.; Matsumura, K. Dystroglycan is a binding protein of laminin and merosin in peripheral nerve. FEBS letters. 1994-09-19, 352 (1): 49–53 [2021-11-10]. ISSN 0014-5793. PMID 7925941. doi:10.1016/0014-5793(94)00917-1. （原始内容存档于2022-03-13）.
Moser, T. L.; Enghild, J. J.; Pizzo, S. V.; Stack, M. S. The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator. The Journal of Biological Chemistry. 1993-09-05, 268 (25): 18917–18923 [2021-11-10]. ISSN 0021-9258. PMID 8360181. （原始内容存档于2021-11-10）. 、
Yurchenco, P. D.; Sung, U.; Ward, M. D.; Yamada, Y.; O'Rear, J. J. Recombinant laminin G domain mediates myoblast adhesion and heparin binding. The Journal of Biological Chemistry. 1993-04-15, 268 (11): 8356–8365 [2021-11-10]. ISSN 0021-9258. PMID 8463343. （原始内容存档于2021-11-10）.
Ancsin, J. B.; Kisilevsky, R. Characterization of high affinity binding between laminin and the acute-phase protein, serum amyloid A. The Journal of Biological Chemistry. 1997-01-03, 272 (1): 406–413 [2021-11-10]. ISSN 0021-9258. PMID 8995276. doi:10.1074/jbc.272.1.406. （原始内容存档于2021-11-10）.
Zahedi, K. Characterization of the binding of serum amyloid P to laminin. The Journal of Biological Chemistry. 1997-01-24, 272 (4): 2143–2148 [2021-11-10]. ISSN 0021-9258. PMID 8999915. （原始内容存档于2021-11-10）.
Utani, A.; Nomizu, M.; Yamada, Y. Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences. The Journal of Biological Chemistry. 1997-01-31, 272 (5): 2814–2820 [2021-11-10]. ISSN 0021-9258. PMID 9006922. doi:10.1074/jbc.272.5.2814. （原始内容存档于2021-11-10）.
Cáceres, J.; Brandan, E. Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans. Journal of Cellular Biochemistry. 1997-05, 65 (2): 145–158 [2021-11-10]. ISSN 0730-2312. PMID 9136074. doi:10.1002/(sici)1097-4644(199705)65:2<145::aid-jcb2>3.0.co;2-u. （原始内容存档于2021-11-10）.
Chen, M.; Marinkovich, M. P.; Veis, A.; Cai, X.; Rao, C. N.; O'Toole, E. A.; Woodley, D. T. Interactions of the amino-terminal noncollagenous (NC1) domain of type VII collagen with extracellular matrix components. A potential role in epidermal-dermal adherence in human skin. The Journal of Biological Chemistry. 1997-06-06, 272 (23): 14516–14522 [2021-11-10]. ISSN 0021-9258. PMID 9169408. doi:10.1074/jbc.272.23.14516. （原始内容存档于2022-04-06）.
Schuger, L.; Skubitz, A. P.; Zhang, J.; Sorokin, L.; He, L. Laminin alpha1 chain synthesis in the mouse developing lung: requirement for epithelial-mesenchymal contact and possible role in bronchial smooth muscle development. The Journal of Cell Biology. 1997-10-20, 139 (2): 553–562 [2021-11-10]. ISSN 0021-9525. PMC 2139794 . PMID 9334356. doi:10.1083/jcb.139.2.553. （原始内容存档于2021-11-10）.
Mrowiec, T.; Melchar, C.; Górski, A. HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium. Archivum Immunologiae Et Therapiae Experimentalis. 1997, 45 (2-3): 255–259 [2021-11-10]. ISSN 0004-069X. PMID 9597096. （原始内容存档于2021-11-10）.
O'Grady, P.; Thai, T. C.; Saito, H. The laminin-nidogen complex is a ligand for a specific splice isoform of the transmembrane protein tyrosine phosphatase LAR. The Journal of Cell Biology. 1998-06-29, 141 (7): 1675–1684 [2021-11-10]. ISSN 0021-9525. PMC 2133008 . PMID 9647658. doi:10.1083/jcb.141.7.1675. （原始内容存档于2021-11-10）.
Ettner, N.; Göhring, W.; Sasaki, T.; Mann, K.; Timpl, R. The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the heparan sulfate-containing domains of perlecan. FEBS letters. 1998-07-03, 430 (3): 217–221 [2021-11-10]. ISSN 0014-5793. PMID 9688542. doi:10.1016/s0014-5793(98)00601-2. （原始内容存档于2021-11-10）.
Ludwig, H. C.; Rausch, S.; Schallock, K.; Markakis, E. Expression of CD 73 (ecto-5'-nucleotidase) in 165 glioblastomas by immunohistochemistry and electronmicroscopic histochemistry. Anticancer Research. 1999-05, 19 (3A): 1747–1752 [2021-11-10]. ISSN 0250-7005. PMID 10470109. （原始内容存档于2021-11-10）.

这是一篇與生物化學相關的小作品。您可以通过编辑或修订扩充其内容。

[1] 與LAMA1相關的疾病；在維基數據上查看/編輯參考.

[2] 對Laminin subunit alpha 1起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-3] 3.0 ^3.1 ^3.2 GRCh38: Ensembl release 89: ENSG00000101680 - Ensembl, May 2017

[refGRCm38Ensembl-4] 4.0 ^4.1 ^4.2 GRCm38: Ensembl release 89: ENSMUSG00000032796 - Ensembl, May 2017

[5] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2591971-7] Nagayoshi, T.; Mattei, M. G.; Passage, E.; Knowlton, R.; Chu, M. L.; Uitto, J. Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3. Genomics. 1989-11, 5 (4): 932–935 [2021-11-10]. ISSN 0888-7543. PMID 2591971. doi:10.1016/0888-7543(89)90136-5. （原始内容存档于2021-11-10）.

[entrez-8] LAMA1 laminin subunit alpha 1 [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2021-11-10]. （原始内容存档于2021-11-10）.

[pmid9006922-9] Utani, A.; Nomizu, M.; Yamada, Y. Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences. The Journal of Biological Chemistry. 1997-01-31, 272 (5): 2814–2820 [2021-11-10]. ISSN 0021-9258. PMID 9006922. doi:10.1074/jbc.272.5.2814. （原始内容存档于2021-11-10）.

[pmid10934193-10] Talts, J. F.; Sasaki, T.; Miosge, N.; Göhring, W.; Mann, K.; Mayne, R.; Timpl, R. Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues. The Journal of Biological Chemistry. 2000-11-10, 275 (45): 35192–35199 [2021-11-10]. ISSN 0021-9258. PMID 10934193. doi:10.1074/jbc.M003261200. （原始内容存档于2022-01-21）.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]