早幼粒细胞白血病蛋白：修订间差异

Promyelocytic leukemia; 早幼粒细胞白血病蛋白
	PDB rendering based on 1bor.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1BOR
标识
代号	PML; MYL; PP8675; RNF71; TRIM19
扩展标识	遗传学：102578 鼠基因：104662 同源基因：13245 GeneCards: PML Gene
基因本体论描述
分子功能	· DNA binding; · transcription coactivator activity; · protein binding; · zinc ion binding; · ubiquitin protein ligase binding; · SUMO binding; · protein homodimerization activity; · SMAD binding; · protein heterodimerization activity; · cobalt ion binding;
细胞成分	· nucleus; · nucleoplasm; · nucleolus; · cytoplasm; · cytosol; · nuclear matrix; · PML body; · early endosome membrane; · nuclear membrane; · extrinsic component of endoplasmic reticulum membrane;
生物过程	· response to hypoxia; · regulation of protein phosphorylation; · positive regulation of defense response to virus by host; · transcription, DNA-templated; · regulation of transcription, DNA-templated; · protein complex assembly; · protein targeting; · apoptotic process; · activation of cysteine-type endopeptidase activity involved in apoptotic process; · DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; · cell cycle arrest; · transforming growth factor beta receptor signaling pathway; · common-partner SMAD protein phosphorylation; · SMAD protein import into nucleus; · negative regulation of cell proliferation; · intrinsic apoptotic signaling pathway in response to DNA damage; · intrinsic apoptotic signaling pathway in response to oxidative stress; · response to UV; · response to gamma radiation; · regulation of calcium ion transport into cytosol; · viral process; · negative regulation of angiogenesis; · cytokine-mediated signaling pathway; · myeloid cell differentiation; · negative regulation of cell growth; · PML body organization; · positive regulation of histone deacetylation; · negative regulation of telomere maintenance via telomerase; · endoplasmic reticulum calcium ion homeostasis; · circadian regulation of gene expression; · negative regulation of translation in response to oxidative stress; · response to cytokine; · regulation of circadian rhythm; · intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; · entrainment of circadian clock by photoperiod; · proteasome-mediated ubiquitin-dependent protein catabolic process; · innate immune response; · cell fate commitment; · regulation of MHC class I biosynthetic process; · negative regulation of transcription, DNA-templated; · negative regulation of mitotic cell cycle; · retinoic acid receptor signaling pathway; · protein stabilization; · maintenance of protein location in nucleus; · defense response to virus; · negative regulation of telomerase activity; · positive regulation of apoptotic process involved in mammary gland involution; · interferon-gamma-mediated signaling pathway; · branching involved in mammary gland duct morphogenesis; · intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; · cellular response to interleukin-4; · cellular senescence; · extrinsic apoptotic signaling pathway; · negative regulation of viral release from host cell; · negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; · regulation of double-strand break repair; · positive regulation of extrinsic apoptotic signaling pathway;
	Sources: Amigo / QuickGO
直系同源体
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2015年2月8日 (日) 14:36的版本

早幼粒细胞白血病蛋白是指可能的转录因子可能的转录因子（英語：Probable transcription factor PML），是一个由人类基因 PML 编码的抑癌蛋白。

功能

已隱藏部分未翻譯内容，歡迎參與翻譯。

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies (Nuclear dots) where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.^[1]

互作

早幼粒细胞白血病蛋白可与下列蛋白質发生交互作用：

另见

RING finger domain

参考文献

^ Entrez Gene: PML promyelocytic leukemia.
^ Kojic, S; Medeot, E; Guccione, E; Krmac, H; Zara, I; Martinelli, V; et al. The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle. J. Mol. Biol. May 2004, 339 (2): 313–25. PMID 15136035. doi:10.1016/j.jmb.2004.03.071. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ ^3.0 ^3.1 Zhong, S; Delva, L; Rachez, C; Cenciarelli, C; Gandini, D; Zhang, H; et al. A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins. Nat. Genet. Nov 1999, 23 (3): 287–95. PMID 10610177. doi:10.1038/15463. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ ^4.0 ^4.1 Matsuzaki, K; Minami, T; Tojo, M; Honda, Y; Saitoh, N; Nagahiro, S; et al. PML-nuclear bodies are involved in cellular serum response. Genes Cells. Mar 2003, 8 (3): 275–86. PMID 12622724. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Doucas, V; Tini, M; Egan, DA; Evans, RM. Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling. Proc. Natl. Acad. Sci. U.S.A. Mar 1999, 96 (6): 2627–32. PMC 15819 . PMID 10077561. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Marcello, A; Ferrari, A; Pellegrini, V; Pegoraro, G; Lusic, M; Beltram, F; et al. Recruitment of human cyclin T1 to nuclear bodies through direct interaction with the PML protein. EMBO J. May 2003, 22 (9): 2156–66. PMC 156077 . PMID 12727882. doi:10.1093/emboj/cdg205. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Ishov, AM; Sotnikov, AG; Negorev, D; Vladimirova, OV; Neff, N; Kamitani, T; et al. PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1. J. Cell Biol. Oct 1999, 147 (2): 221–34. PMC 2174231 . PMID 10525530. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Li, H; Leo, C; Zhu, J; Wu, X; O'Neil, J; Park, EJ; et al. Sequestration and inhibition of Daxx-mediated transcriptional repression by PML. Mol. Cell. Biol. Mar 2000, 20 (5): 1784–96. PMC 85360 . PMID 10669754. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Lehembre, F; Müller, S; Pandolfi, PP; Dejean, A. Regulation of Pax3 transcriptional activity by SUMO-1-modified PML. Oncogene. Jan 2001, 20 (1): 1–9. PMID 11244500. doi:10.1038/sj.onc.1204063. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Zhong, S; Salomoni, P; Ronchetti, S; Guo, A; Ruggero, D; Pandolfi, PP. Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis. J. Exp. Med. Feb 2000, 191 (4): 631–40. PMC 2195846 . PMID 10684855. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Tsuzuki, S; Towatari, M; Saito, H; Enver, T. Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein. Mol. Cell. Biol. Sep 2000, 20 (17): 6276–86. PMC 86102 . PMID 10938104. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Khan, MM; Nomura, T; Kim, H; Kaul, SC; Wadhwa, R; Shinagawa, T; et al. Role of PML and PML-RARalpha in Mad-mediated transcriptional repression. Mol. Cell. Jun 2001, 7 (6): 1233–43. PMID 11430826. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ ^13.0 ^13.1 Wu, WS; Vallian, S; Seto, E; Yang, WM; Edmondson, D; Roth, S; et al. The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases. Mol. Cell. Biol. Apr 2001, 21 (7): 2259–68. PMC 86860 . PMID 11259576. doi:10.1128/MCB.21.7.2259-2268.2001. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Topcu, Z; Mack, DL; Hromas, RA; Borden, KL. The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control. Oncogene. Nov 1999, 18 (50): 7091–100. PMID 10597310. doi:10.1038/sj.onc.1203201. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Shin, J; Park, B; Cho, S; Lee, S; Kim, Y; Lee, SO; et al. Promyelocytic leukemia is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase. J. Biol. Chem. Sep 2004, 279 (39): 40994–1003. PMID 15273249. doi:10.1074/jbc.M407369200. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Dahle, Ø; Bakke, O; Gabrielsen, OS. c-Myb associates with PML in nuclear bodies in hematopoietic cells. Exp. Cell Res. Jul 2004, 297 (1): 118–26. PMID 15194430. doi:10.1016/j.yexcr.2004.03.014. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
^ ^17.0 ^17.1 Kurki, S; Latonen, L; Laiho, M. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. J. Cell. Sci. Oct 2003, 116 (Pt 19): 3917–25. PMID 12915590. doi:10.1242/jcs.00714. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
^ ^18.0 ^18.1 Bernardi, R; Scaglioni, PP; Bergmann, S; Horn, HF; Vousden, KH; Pandolfi, PP. PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Nat. Cell Biol. Jul 2004, 6 (7): 665–72. PMID 15195100. doi:10.1038/ncb1147. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Zhu, H; Wu, L; Maki, CG. MDM2 and promyelocytic leukemia antagonize each other through their direct interaction with p53. J. Biol. Chem. Dec 2003, 278 (49): 49286–92. PMID 14507915. doi:10.1074/jbc.M308302200. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
^ Wei, X; Yu, ZK; Ramalingam, A; Grossman, SR; Yu, JH; Bloch, DB; et al. Physical and functional interactions between PML and MDM2. J. Biol. Chem. Aug 2003, 278 (31): 29288–97. PMID 12759344. doi:10.1074/jbc.M212215200. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Wu, WS; Xu, ZX; Ran, R; Meng, F; Chang, KS. Promyelocytic leukemia protein PML inhibits Nur77-mediated transcription through specific functional interactions. Oncogene. May 2002, 21 (24): 3925–33. PMID 12032831. doi:10.1038/sj.onc.1205491. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Hong, SH; Yang, Z; Privalsky, ML. Arsenic trioxide is a potent inhibitor of the interaction of SMRT corepressor with Its transcription factor partners, including the PML-retinoic acid receptor alpha oncoprotein found in human acute promyelocytic leukemia. Mol. Cell. Biol. Nov 2001, 21 (21): 7172–82. PMC 99892 . PMID 11585900. doi:10.1128/MCB.21.21.7172-7182.2001. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Fogal, V; Gostissa, M; Sandy, P; Zacchi, P; Sternsdorf, T; Jensen, K; et al. Regulation of p53 activity in nuclear bodies by a specific PML isoform. EMBO J. Nov 2000, 19 (22): 6185–95. PMC 305840 . PMID 11080164. doi:10.1093/emboj/19.22.6185. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Guo, A; Salomoni, P; Luo, J; Shih, A; Zhong, S; Gu, W; et al. The function of PML in p53-dependent apoptosis. Nat. Cell Biol. Oct 2000, 2 (10): 730–6. PMID 11025664. doi:10.1038/35036365. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Alcalay, M; Tomassoni, L; Colombo, E; Stoldt, S; Grignani, F; Fagioli, M; et al. The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein. Mol. Cell. Biol. Feb 1998, 18 (2): 1084–93. PMC 108821 . PMID 9448006. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Kawasaki, A; Matsumura, I; Kataoka, Y; Takigawa, E; Nakajima, K; Kanakura, Y. Opposing effects of PML and PML/RAR alpha on STAT3 activity. Blood. May 2003, 101 (9): 3668–73. PMID 12506013. doi:10.1182/blood-2002-08-2474. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Lin, DY; Shih, HM. Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration. J. Biol. Chem. Jul 2002, 277 (28): 25446–56. PMID 11948183. doi:10.1074/jbc.M200633200. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
^ Kamitani, T; Nguyen, HP; Kito, K; Fukuda-Kamitani, T; Yeh, ET. Covalent modification of PML by the sentrin family of ubiquitin-like proteins. J. Biol. Chem. Feb 1998, 273 (6): 3117–20. PMID 9452416. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Vallian, S; Chin, KV; Chang, KS. The promyelocytic leukemia protein interacts with Sp1 and inhibits its transactivation of the epidermal growth factor receptor promoter. Mol. Cell. Biol. Dec 1998, 18 (12): 7147–56. PMC 109296 . PMID 9819401. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Xu, ZX; Timanova-Atanasova, A; Zhao, RX; Chang, KS. PML colocalizes with and stabilizes the DNA damage response protein TopBP1. Mol. Cell. Biol. Jun 2003, 23 (12): 4247–56. PMC 156140 . PMID 12773567. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Takahashi, H; Hatakeyama, S; Saitoh, H; Nakayama, KI. Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein. J. Biol. Chem. Feb 2005, 280 (7): 5611–21. PMID 15569683. doi:10.1074/jbc.M408130200. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
^ Koken, MH; Reid, A; Quignon, F; Chelbi-Alix, MK; Davies, JM; Kabarowski, JH; et al. Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies. Proc. Natl. Acad. Sci. U.S.A. Sep 1997, 94 (19): 10255–60. PMC 23349 . PMID 9294197. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

延伸阅读

Zhong, S; Salomoni, P; Pandolfi, PP. The transcriptional role of PML and the nuclear body. Nat. Cell Biol. 2000, 2 (5): E85–90. PMID 10806494. doi:10.1038/35010583. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
Jensen, K; Shiels, C; Freemont, PS. PML protein isoforms and the RBCC/TRIM motif. Oncogene. 2001, 20 (49): 7223–33. PMID 11704850. doi:10.1038/sj.onc.1204765. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
Pearson, M; Pelicci, PG. PML interaction with p53 and its role in apoptosis and replicative senescence. Oncogene. 2001, 20 (49): 7250–6. PMID 11704853. doi:10.1038/sj.onc.1204856. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
Salomoni, P; Pandolfi, PP. The role of PML in tumor suppression. Cell. 2002, 108 (2): 165–70. PMID 11832207. doi:10.1016/S0092-8674(02)00626-8. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
Combes, R; Balls, M; Bansil, L; Barratt, M; Bell, D; Botham, P; et al. An assessment of progress in the use of alternatives in toxicity testing since the publication of the report of the second FRAME Toxicity Committee (1991). Alternatives to laboratory animals : ATLA. 2002, 30 (4): 365–406. PMID 12234245. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)
Bernardi, R; Pandolfi, PP. Role of PML and the PML-nuclear body in the control of programmed cell death. Oncogene. 2004, 22 (56): 9048–57. PMID 14663483. doi:10.1038/sj.onc.1207106. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)
Beez, S; Demmer, P; Puccetti, E. Targeting the Acute Promyelocytic Leukemia-Associated Fusion Proteins PML/RARα and PLZF/RARα with Interfering Peptides. PLOS ONE. 2012, 7 (11): e48636. PMC 3494703 . PMID 23152790. doi:10.1371/journal.pone.0048636. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

外部链接

醫學主題詞表（MeSH）：PML+protein,+human

[1] Entrez Gene: PML promyelocytic leukemia.

[pmid15136035-2] Kojic, S; Medeot, E; Guccione, E; Krmac, H; Zara, I; Martinelli, V; et al. The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle. J. Mol. Biol. May 2004, 339 (2): 313–25. PMID 15136035. doi:10.1016/j.jmb.2004.03.071. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid10610177-3] 3.0 ^3.1 Zhong, S; Delva, L; Rachez, C; Cenciarelli, C; Gandini, D; Zhang, H; et al. A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins. Nat. Genet. Nov 1999, 23 (3): 287–95. PMID 10610177. doi:10.1038/15463. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid12622724-4] 4.0 ^4.1 Matsuzaki, K; Minami, T; Tojo, M; Honda, Y; Saitoh, N; Nagahiro, S; et al. PML-nuclear bodies are involved in cellular serum response. Genes Cells. Mar 2003, 8 (3): 275–86. PMID 12622724. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid10077561-5] Doucas, V; Tini, M; Egan, DA; Evans, RM. Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling. Proc. Natl. Acad. Sci. U.S.A. Mar 1999, 96 (6): 2627–32. PMC 15819 . PMID 10077561. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid12727882-6] Marcello, A; Ferrari, A; Pellegrini, V; Pegoraro, G; Lusic, M; Beltram, F; et al. Recruitment of human cyclin T1 to nuclear bodies through direct interaction with the PML protein. EMBO J. May 2003, 22 (9): 2156–66. PMC 156077 . PMID 12727882. doi:10.1093/emboj/cdg205. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid10525530-7] Ishov, AM; Sotnikov, AG; Negorev, D; Vladimirova, OV; Neff, N; Kamitani, T; et al. PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1. J. Cell Biol. Oct 1999, 147 (2): 221–34. PMC 2174231 . PMID 10525530. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid10669754-8] Li, H; Leo, C; Zhu, J; Wu, X; O'Neil, J; Park, EJ; et al. Sequestration and inhibition of Daxx-mediated transcriptional repression by PML. Mol. Cell. Biol. Mar 2000, 20 (5): 1784–96. PMC 85360 . PMID 10669754. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid11244500-9] Lehembre, F; Müller, S; Pandolfi, PP; Dejean, A. Regulation of Pax3 transcriptional activity by SUMO-1-modified PML. Oncogene. Jan 2001, 20 (1): 1–9. PMID 11244500. doi:10.1038/sj.onc.1204063. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid10684855-10] Zhong, S; Salomoni, P; Ronchetti, S; Guo, A; Ruggero, D; Pandolfi, PP. Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis. J. Exp. Med. Feb 2000, 191 (4): 631–40. PMC 2195846 . PMID 10684855. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid10938104-11] Tsuzuki, S; Towatari, M; Saito, H; Enver, T. Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein. Mol. Cell. Biol. Sep 2000, 20 (17): 6276–86. PMC 86102 . PMID 10938104. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid11430826-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Khan, MM; Nomura, T; Kim, H; Kaul, SC; Wadhwa, R; Shinagawa, T; et al. Role of PML and PML-RARalpha in Mad-mediated transcriptional repression. Mol. Cell. Jun 2001, 7 (6): 1233–43. PMID 11430826. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

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[pmid12915590-17] 17.0 ^17.1 Kurki, S; Latonen, L; Laiho, M. Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. J. Cell. Sci. Oct 2003, 116 (Pt 19): 3917–25. PMID 12915590. doi:10.1242/jcs.00714. 已忽略未知参数|author-separator= (帮助); 已忽略未知参数|author-name-separator= (帮助)

[pmid15195100-18] 18.0 ^18.1 Bernardi, R; Scaglioni, PP; Bergmann, S; Horn, HF; Vousden, KH; Pandolfi, PP. PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Nat. Cell Biol. Jul 2004, 6 (7): 665–72. PMID 15195100. doi:10.1038/ncb1147. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

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[pmid12759344-20] Wei, X; Yu, ZK; Ramalingam, A; Grossman, SR; Yu, JH; Bloch, DB; et al. Physical and functional interactions between PML and MDM2. J. Biol. Chem. Aug 2003, 278 (31): 29288–97. PMID 12759344. doi:10.1074/jbc.M212215200. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid12032831-21] Wu, WS; Xu, ZX; Ran, R; Meng, F; Chang, KS. Promyelocytic leukemia protein PML inhibits Nur77-mediated transcription through specific functional interactions. Oncogene. May 2002, 21 (24): 3925–33. PMID 12032831. doi:10.1038/sj.onc.1205491. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

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[pmid9448006-25] Alcalay, M; Tomassoni, L; Colombo, E; Stoldt, S; Grignani, F; Fagioli, M; et al. The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein. Mol. Cell. Biol. Feb 1998, 18 (2): 1084–93. PMC 108821 . PMID 9448006. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

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[pmid9452416-28] Kamitani, T; Nguyen, HP; Kito, K; Fukuda-Kamitani, T; Yeh, ET. Covalent modification of PML by the sentrin family of ubiquitin-like proteins. J. Biol. Chem. Feb 1998, 273 (6): 3117–20. PMID 9452416. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

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[pmid15569683-31] Takahashi, H; Hatakeyama, S; Saitoh, H; Nakayama, KI. Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein. J. Biol. Chem. Feb 2005, 280 (7): 5611–21. PMID 15569683. doi:10.1074/jbc.M408130200. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

[pmid9294197-32] Koken, MH; Reid, A; Quignon, F; Chelbi-Alix, MK; Davies, JM; Kabarowski, JH; et al. Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies. Proc. Natl. Acad. Sci. U.S.A. Sep 1997, 94 (19): 10255–60. PMC 23349 . PMID 9294197. 已忽略未知参数|author-name-separator= (帮助); 已忽略未知参数|author-separator= (帮助)

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