视网膜母细胞瘤蛋白

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Retinoblastoma 1

PDB rendering based on 1ad6.
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 RB1; OSRC; RB; p105-Rb; pRb; pp110
扩展标识 遗传学614041 鼠基因97874 同源基因272 ChEMBL: 5288 GeneCards: RB1 Gene
RNA表达模式
PBB GE RB1 203132 at.png
PBB GE RB1 211540 s at.png
更多表达数据
直系同源体
物种 人类 鼠类
Entrez 5925 19645
Ensembl ENSG00000139687 ENSMUSG00000022105
UniProt P06400 P13405
mRNA序列 NM_000321 NM_009029
蛋白序列 NP_000312 NP_033055
基因位置 Chr 13:
48.88 – 49.06 Mb
Chr 14:
73.18 – 73.33 Mb
PubMed查询 [1] [2]

视网膜母细胞瘤蛋白英语retinoblastoma protein,常缩写为pRbRBRB1)又译为成视网膜细胞瘤蛋白是一种抑癌蛋白,并在几种主要的癌症发生时失活[1]。pRb的功能之一是通过抑制细胞周期进程直到细胞准备妥当来防止细胞过度生长。

pRb是袋状蛋白家族的一员,其特点是有一个口袋状的结构用以结合其它蛋白[2][3]。使得一些致癌变蛋白,比如高危险群人类乳突病毒所感染的细胞产生的蛋白,结合并抑制pRb,最终导致癌症。

相互作用[编辑]

已知Rb蛋白与下列蛋白质有相互作用关系:

细胞凋亡中涉及的信号通路一览

参考文献[编辑]

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视网膜母细胞瘤蛋白引用了美国国家医学图书馆提供的資料,这些資料属于公共领域


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