STAT2

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Signal transducer and activator of transcription 2, 113kDa
信号转导及转录激活蛋白2,113千道尔顿
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 STAT2; ISGF-3; P113; STAT113
扩展标识 遗传学600556 鼠基因103039 同源基因3952 GeneCards: STAT2 Gene
RNA表达模式
PBB GE STAT2 205170 at tn.png
PBB GE STAT2 217199 s at tn.png
更多表达数据
直系同源体
物种 人类 鼠类
Entrez 6773 20847
Ensembl ENSG00000170581 ENSMUSG00000040033
UniProt P52630 Q9QXJ2
mRNA序列 NM_005419 NM_019963
蛋白序列 NP_005410 NP_064347
基因位置 Chr 12:
56.74 – 56.75 Mb
Chr 10:
128.27 – 128.29 Mb
PubMed查询 [1] [2]

信号转导及转录激活蛋白2英语Signal transducer and activator of transcription 2)是一種由人类基因STAT2 所表达的蛋白质[1][2]

相互作用[编辑]

STAT2能与MED14[3]CREB结合蛋白英语CREB-binding protein[4]SMARCA4[5]STAT1[6][7][8]IFNAR2[9][10] IFNAR1[9][11][12]ISGF3G[13][14]相互作用

参考文献[编辑]

  1. ^ Yan R, Qureshi S, Zhong Z, Wen Z, Darnell JE Jr. The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2. Nucleic Acids Res. Apr 1995, 23 (3): 459–63. doi:10.1093/nar/23.3.459. PMC 306697. PMID 7885841. 
  2. ^ Entrez Gene: STAT2 signal transducer and activator of transcription 2, 113kDa. 
  3. ^ Lau, Joe F; Nusinzon Inna, Burakov Darya, Freedman Leonard P, Horvath Curt M. Role of metazoan mediator proteins in interferon-responsive transcription. Mol. Cell. Biol. (United States). Jan 2003, 23 (2): 620–8. doi:10.1128/MCB.23.2.620-628.2003. ISSN 0270-7306. PMC 151539. PMID 12509459. 
  4. ^ Bhattacharya, S; Eckner R, Grossman S, Oldread E, Arany Z, D'Andrea A, Livingston D M. Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. Nature (ENGLAND). Sep 1996, 383 (6598): 344–7. doi:10.1038/383344a0. ISSN 0028-0836. PMID 8848048. 
  5. ^ Huang, Mei; Qian Feng, Hu Yuanyu, Ang Chengeng, Li Zhong, Wen Zilong. Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes. Nat. Cell Biol. (England). Oct 2002, 4 (10): 774–81. doi:10.1038/ncb855. ISSN 1465-7392. PMID 12244326. 
  6. ^ Li, X; Leung S, Qureshi S, Darnell J E, Stark G R. Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha. J. Biol. Chem. (UNITED STATES). Mar 1996, 271 (10): 5790–4. doi:10.1074/jbc.271.10.5790. ISSN 0021-9258. PMID 8621447. 
  7. ^ Dumler, I; Kopmann A, Wagner K, Mayboroda O A, Jerke U, Dietz R, Haller H, Gulba D C. Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells. J. Biol. Chem. (UNITED STATES). Aug 1999, 274 (34): 24059–65. doi:10.1074/jbc.274.34.24059. ISSN 0021-9258. PMID 10446176. 
  8. ^ Fagerlund, Riku; Mélen Krister, Kinnunen Leena, Julkunen Ilkka. Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5. J. Biol. Chem. (United States). Aug 2002, 277 (33): 30072–8. doi:10.1074/jbc.M202943200. ISSN 0021-9258. PMID 12048190. 
  9. ^ 9.0 9.1 Li, X; Leung S, Kerr I M, Stark G R. Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. Mol. Cell. Biol. (UNITED STATES). Apr 1997, 17 (4): 2048–56. ISSN 0270-7306. PMC 232052. PMID 9121453. 
  10. ^ Nguyen, Vinh-Phúc; Saleh Abu Z M, Arch Allison E, Yan Hai, Piazza Flavia, Kim John, Krolewski John J. Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling. J. Biol. Chem. (United States). Mar 2002, 277 (12): 9713–21. doi:10.1074/jbc.M111161200. ISSN 0021-9258. PMID 11786546. 
  11. ^ Uddin, S; Chamdin A, Platanias L C. Interaction of the transcriptional activator Stat-2 with the type I interferon receptor. J. Biol. Chem. (UNITED STATES). Oct 1995, 270 (42): 24627–30. doi:10.1074/jbc.270.42.24627. ISSN 0021-9258. PMID 7559568. 
  12. ^ Yan, H; Krishnan K, Greenlund A C, Gupta S, Lim J T, Schreiber R D, Schindler C W, Krolewski J J. Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. (ENGLAND). Mar 1996, 15 (5): 1064–74. ISSN 0261-4189. PMC 450004. PMID 8605876. 
  13. ^ Horvath, C M; Stark G R, Kerr I M, Darnell J E. Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex. Mol. Cell. Biol. (UNITED STATES). Dec 1996, 16 (12): 6957–64. ISSN 0270-7306. PMC 231699. PMID 8943351. 
  14. ^ Martinez-Moczygemba, M; Gutch M J, French D L, Reich N C. Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3. J. Biol. Chem. (UNITED STATES). Aug 1997, 272 (32): 20070–6. doi:10.1074/jbc.272.32.20070. ISSN 0021-9258. PMID 9242679. 

延伸阅读[编辑]

外部链接[编辑]

STAT2引用了美国国家医学图书馆提供的資料,这些資料属于公共领域