STAT1

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Signal transducer and activator of transcription 1, 91kDa
信号转导及转录激活蛋白1,91千道尔顿

STAT1 bound to DNA
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 STAT1; CANDF7; ISGF-3; STAT91
扩展标识 遗传学600555 鼠基因103063 同源基因21428 ChEMBL: 6101 GeneCards: STAT1 Gene
RNA表达模式
PBB GE STAT1 200887 s at tn.png
更多表达数据
直系同源体
物种 人类 鼠类
Entrez 6772 20846
Ensembl ENSG00000115415 ENSMUSG00000026104
UniProt P42224 P42225
mRNA序列 NM_007315 NM_001205313
蛋白序列 NP_009330 NP_001192242
基因位置 Chr 2:
191.83 – 191.89 Mb
Chr 1:
52.12 – 52.16 Mb
PubMed查询 [1] [2]

STAT1转录因子信号转导及转录激活蛋白(STAT蛋白)家族的一员。STAT1涉及I型II型III型干扰素激活基因的正调控。在干扰素-γ刺激下,STAT1会组成同源二聚体或与STAT3组成异二聚体结合到GAS(Interferon-Gamma-Activated Sequence,干扰素γ激活序列)启动子上;而在干扰素-α或干扰素-β刺激下,STAT1会与STAT2组成异二聚体结合到ISREInterferon-Stimulated Response Element,干扰素激活反应元件)启动子上[1]。在这两种情况下,STAT二聚体与启动子的结合都会导致ISGInterferon-Stimulated Genes,干扰素激活基因)的表达。

Expression of STAT1 can be induced with diallyl disulfide, a compound in garlic.[2]

相互作用[编辑]

STAT1能与下列蛋白质发生相互作用

参考文献[编辑]

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