芳香烃受体

编辑

芳香烃受体
标识
代号	AHR; bHLHe76
扩展标识	遗传学：600253 鼠基因：105043 同源基因：1224
基因本体论描述 分子功能 · DNA binding · DNA binding · sequence-specific DNA binding transcription factor activity · sequence-specific distal enhancer binding RNA polymerase II transcription factor activity · signal transducer activity · receptor activity · ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity · protein binding · transcription factor binding · sequence-specific DNA binding · transcription regulatory region DNA binding · protein heterodimerization activity · protein dimerization activity · Hsp90 protein binding 细胞成分 · nucleus · transcription factor complex · nucleolus · cytoplasm · cytosol · cytosolic aryl hydrocarbon receptor complex 生物过程 · negative regulation of transcription from RNA polymerase II promoter · cell morphogenesis · ovarian follicle development · blood vessel development · patterning of blood vessels · liver development · blood vessel remodeling · immune system process · negative regulation of systemic arterial blood pressure · circumferential growth involved in left ventricle morphogenesis · regulation of transcription, DNA-dependent · regulation of transcription, DNA-dependent · regulation of transcription from RNA polymerase II promoter · transcription from RNA polymerase II promoter · xenobiotic metabolic process · apoptotic process · response to stress · cell cycle · response to xenobiotic stimulus · regulation of gene expression · response to organic cyclic compound · intracellular receptor mediated signaling pathway · prostate gland development · regulation of B cell proliferation · response to estradiol stimulus · embryonic hemopoiesis · post-embryonic hemopoiesis · positive regulation of growth rate · camera-type eye development · T cell homeostasis · positive regulation of cell size · positive regulation of transcription, DNA-dependent · positive regulation of RNA polymerase II transcriptional preinitiation complex assembly · negative regulation of vasoconstriction · blood vessel morphogenesis · spleen development · smooth muscle tissue development · regulation of blood vessel size · negative regulation of necrotic cell death · venous blood vessel development · kidney morphogenesis · common bile duct development · cellular response to glucocorticoid stimulus · glomerulus morphogenesis
直系同源体
物种	人类	鼠类
Entrez	196	11622
Ensembl	ENSG00000106546	ENSMUSG00000019256
UniProt	P35869	P30561
参考序列	NM_001621.4 (mRNA)	NM_013464.4 (mRNA)
	NP_001612.1（蛋白）	NP_038492.1（蛋白）
基因位置	染色体7: 17.34 - 17.39 Mb	染色体12: 36.18 - 36.22 Mb
PubMed查询	[1]	[2]

芳香烃受体（英语：Aryl hydrocarbon receptor，或称为芳烃受体或芳基烃受体，简称为AhR或AHR）是基本螺旋-环-螺旋转录因子家族中的一个成员。此受体的生理学配体未知，但他会结合一些例如天然植物黄酮类化合物、多酚类与吲哚类等外源配体，人造的多环芳烃以及二噁英样物质同样也是。AhR是一种通常情况下无活性而与一些共分子伴侣胞质溶胶结合的转录因子。一旦配体结合到例如2,3,7,8-四氯二苯二氧芑（TCDD）等化学物质上时，分子伴侣离解并导致AhR转移到细胞核中并与ARNT（芳香烃受体核转运体）二聚化，致使基因转录产生改变。

外部链接

• MeSH（醫學主題詞）上面的Aryl+hydrocarbon+receptor