腺苷脫氨酶
（重定向自腺苷脱氨酶）
| Adenosine/AMP deaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of plasmodium yoelii adenosine deaminase (py02076) | |||||||||
| 鑑定 | |||||||||
| 標誌 | A_deaminase | ||||||||
| Pfam | PF00962（旧版） | ||||||||
| Pfam宗系 | CL0034（旧版） | ||||||||
| InterPro | IPR001365 | ||||||||
| PROSITE | PDOC00419 | ||||||||
| SCOP | 1add / SUPFAM | ||||||||
| |||||||||
| Adenosine deaminase (editase) domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 鑑定 | |||||||||
| 標誌 | A_deamin | ||||||||
| Pfam | PF02137（旧版） | ||||||||
| InterPro | IPR002466 | ||||||||
| PROSITE | PDOC00419 | ||||||||
| SCOP | 1add / SUPFAM | ||||||||
| |||||||||
| Adenosine/AMP deaminase N-terminal | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 鑑定 | |||||||||
| 標誌 | A_deaminase_N | ||||||||
| Pfam | PF08451（旧版） | ||||||||
| InterPro | IPR013659 | ||||||||
| |||||||||
腺苷脫氨酶（英語：Adenosine deaminase）的是一種參與嘌呤代謝作用的酶。它是用作拆解食物組織中的核酸中的腺苷。在人體中，它主要參與了免疫細胞的製造。若該酶突變，會造成T細胞、B細胞及自然殺手細胞皆無法表現的嚴重複合型免疫缺乏症(SCID)。
反應
[编辑]腺苷脫氨酶對腺苷進行不可逆轉的脫氨作用，轉化腺苷為相關的核苷肌苷，移除氨基酸組。
病理學
[编辑]腺苷脫氨酶的突變基因使之不容易被表達，這是一些嚴重複合型免疫缺乏症(SCID)的原因。基因突變令ADA被過度產生是溶血性貧血原因之一。有一些證據表明，一個不同的等位基因(ADA2)可能會導致自閉症。
ADA活性異常與多種疾病相關，如當人體發生結核桿菌侵襲時，人體主要啓動細胞免疫，T淋巴細胞和單核巨噬細胞被分枝桿菌激活可引起ADA的活性增強，且間皮細胞吞噬分枝桿菌後產生的特異性細胞因子亦誘導ADA的活性增強。
参考文献
[编辑]深入阅读
[编辑]- da Cunha JG. [Adenosine deaminase. A pluridisciplinary enzyme]. Acta médica portuguesa. 1992, 4 (6): 315–23. PMID 1807098.
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. PMID 2783588. doi:10.1172/JCI113909. - Murray JL, Perez-Soler R, Bywaters D, Hersh EM. Decreased adenosine deaminase (ADA) and 5'nucleotidase (5NT) activity in peripheral blood T cells in Hodgkin disease. Am. J. Hematol. 1986, 21 (1): 57–66. PMID 3010705. doi:10.1002/ajh.2830210108.
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- Daddona PE, Shewach DS, Kelley WN; et al. Human adenosine deaminase. cDNA and complete primary amino acid sequence. J. Biol. Chem. 1984, 259 (19): 12101–6. PMID 6090454.
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