载脂蛋白C1

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Apolipoprotein C-I
载脂蛋白C1
PDB rendering based on 1ioj.
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 APOC1
扩展标识 遗传学107710 鼠基因88053 同源基因1244 GeneCards英语GeneCards: APOC1 Gene
直系同源体
物种 人类 小鼠
Entrez英语Entrez 341 11812
Ensembl ENSG00000130208 ENSMUSG00000040564
UniProt P02654 P34928
mRNA序列 NM_001645 NM_001110009
蛋白序列 NP_001636 NP_001103479
基因位置 Chr 19:
45.42 – 45.42 Mb
Chr 7:
19.69 – 19.69 Mb
PubMed查询 [1] [2]
ApoC-I
PDB 1eze EBI.jpg
structural studies of a baboon (papio sp.) plasma protein inhibitor of cholesteryl ester transferase.
鉴定
标志 ApoC-I
Pfam(蛋白家族查询站) PF04691
InterPro(蛋白数据整合站) IPR006781
SCOP(蛋白结构分类数据站) 1ale

载脂蛋白C1英语:Apolipoprotein C-I)是一个由人类基因 APOC1 编码的脂蛋白[1][2]

功能[编辑]

该基因编码的蛋白质是载脂蛋白C英语apolipoprotein C家族中的一员。

参考文献[编辑]

  1. ^ Tata F, Henry I, Markham AF, Wallis SC, Weil D, Grzeschik KH, Junien C, Williamson R, Humphries SE. Isolation and characterisation of a cDNA clone for human apolipoprotein CI and assignment of the gene to chromosome 19. Hum. Genet. 1985, 69 (4): 345–9. doi:10.1007/BF00291654. PMID 2985493. 
  2. ^ Smit M, van der Kooij-Meijs E, Frants RR, Havekes L, Klasen EC. Apolipoprotein gene cluster on chromosome 19. Definite localization of the APOC2 gene and the polymorphic Hpa I site associated with type III hyperlipoproteinemia. Hum. Genet. January 1988, 78 (1): 90–3. doi:10.1007/BF00291243. PMID 2892779. 

进一步阅读[编辑]

  • Shulman RS, Herbert PN, Wehrly K, Fredrickson DS. Thf complete amino acid sequence of C-I (apoLp-Ser), an apolipoprotein from human very low density lipoproteins. J. Biol. Chem. 1975, 250 (1): 182–90. PMID 166984. 
  • Lauer SJ, Walker D, Elshourbagy NA; 等. Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene. J. Biol. Chem. 1988, 263 (15): 7277–86. PMID 2835369. 
  • Smit M, van der Kooij-Meijs E, Woudt LP; 等. Exact localization of the familial dysbetalipoproteinemia associated HpaI restriction site in the promoter region of the APOC1 gene. Biochem. Biophys. Res. Commun. 1988, 152 (3): 1282–8. doi:10.1016/S0006-291X(88)80424-8. PMID 2897845. 
  • Davison PJ, Norton P, Wallis SC; 等. There are two gene sequences for human apolipoprotein CI (apo CI) on chromosome 19, one of which is 4 kb from the gene for apo E. Biochem. Biophys. Res. Commun. 1986, 136 (3): 876–84. doi:10.1016/0006-291X(86)90414-6. PMID 3013172. 
  • Myklebost O, Rogne S. The gene for human apolipoprotein CI is located 4.3 kilobases away from the apolipoprotein E gene on chromosome 19. Hum. Genet. 1986, 73 (4): 286–9. doi:10.1007/BF00279087. PMID 3017837. 
  • Jackson RL, Sparrow JT, Baker HN; 等. The primary structure of apolopoprotein-serine. J. Biol. Chem. 1974, 249 (16): 5308–13. PMID 4369340. 
  • Knott TJ, Robertson ME, Priestley LM; 等. Characterisation of mRNAs encoding the precursor for human apolipoprotein CI. Nucleic Acids Res. 1984, 12 (9): 3909–15. doi:10.1093/nar/12.9.3909. PMC 318798. PMID 6328444. 
  • Servillo L, Brewer HB, Osborne JC. Evaluation of the mixed interaction between apolipoproteins A-II and C-I equilibrium sedimentation. Biophys. Chem. 1981, 13 (1): 29–38. doi:10.1016/0301-4622(81)80022-1. PMID 6789904. 
  • Curry MD, McConathy WJ, Fesmire JD, Alaupovic P. Quantitative determination of apolipoproteins C-I and C-II in human plasma by separate electroimmunoassays. Clin. Chem. 1981, 27 (4): 543–8. PMID 7471419. 
  • Rozek A, Buchko GW, Cushley RJ. Conformation of two peptides corresponding to human apolipoprotein C-I residues 7-24 and 35-53 in the presence of sodium dodecyl sulfate by CD and NMR spectroscopy. Biochemistry. 1995, 34 (22): 7401–8. doi:10.1021/bi00022a013. PMID 7779782. 
  • Maruyama K, Sugano S. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene. 1994, 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Trask B, Fertitta A, Christensen M; 等. Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers. Genomics. 1993, 15 (1): 133–45. doi:10.1006/geno.1993.1021. PMID 8432525. 
  • Kamino K, Yoshiiwa A, Nishiwaki Y; 等. Genetic association study between senile dementia of Alzheimer's type and APOE/C1/C2 gene cluster. Gerontology. 1996,. 42 Suppl 1: 12–9. doi:10.1159/000213820. PMID 8804993. 
  • Rozek A, Buchko GW, Kanda P, Cushley RJ. Conformational studies of the N-terminal lipid-associating domain of human apolipoprotein C-I by CD and 1H NMR spectroscopy. Protein Sci. 1998, 6 (9): 1858–68. doi:10.1002/pro.5560060906. PMC 2143781. PMID 9300485. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; 等. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. Gene. 1997, 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Halushka MK, Fan JB, Bentley K; 等. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat. Genet. 1999, 22 (3): 239–47. doi:10.1038/10297. PMID 10391210. 
  • Freitas EM, Zhang WJ, Lalonde JP; 等. Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1. DNA Seq. 1999, 9 (2): 89–100. doi:10.3109/10425179809086433. PMID 10520737. 
  • Gautier T, Masson D, de Barros JP; 等. Human apolipoprotein C-I accounts for the ability of plasma high density lipoproteins to inhibit the cholesteryl ester transfer protein activity. J. Biol. Chem. 2001, 275 (48): 37504–9. doi:10.1074/jbc.M007210200. PMID 10978346. 
  • Hartley JL, Temple GF, Brasch MA. DNA cloning using in vitro site-specific recombination. Genome Res. 2001, 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.