CCL9

趋化因子（C-C基序）配体9
Chemokine (C-C motif) ligand 9
趋化因子（C-C基序）配体9; Chemokine (C-C motif) ligand 9
标识
代号	Ccl9; CCF18; MRP-2; Scya10; Scya9
扩展标识	鼠基因：104533 同源基因：86734 GeneCards: Ccl9 Gene
基因本体论描述
分子功能	· cytokine activity; · chemokine activity;
细胞成分	· extracellular region; · extracellular space;
生物过程	· chemotaxis; · immune response;
	Sources: Amigo / QuickGO
直系同源体
物种	人类
Entrez	20308
Ensembl	ENSMUSG00000019122
UniProt	P51670
mRNA序列	NM_011338
蛋白序列	NP_035468
基因位置	Chr 11:; 83.57 – 83.58 Mb
PubMed查询	[1]
	查; 论; 编;

CCL9（英語：Chemokine (C-C motif) ligand 9）是一个小型的细胞因子，属于CC趋化因子家族。它的别名有巨噬细胞炎性蛋白-1γ（英語：macrophage inflammatory protein-1 gamma，MIP-1γ）, 巨噬细胞炎症蛋白相关蛋白-2（英語：macrophage inflammatory protein-related protein-2，MRP-2）以及在啮齿类中使用的CCF18。CCL9还曾经被定名为CCL10，但这个名称已不再使用。

它由淋巴结相关上皮组织（FAE）分泌（如Peyer氏斑块（英语：Peyer's patch）周围），并影响拥有细胞表面分子CD11b与趋化因子受体 CCR1的树突状细胞^[1]。 CCL9 通过其受体CCR1（破骨细胞中最丰富的趋化因子受体）激活破骨细胞，表明了CCL9可能在骨质吸收（英语：bone resorption）中的重要作用^[2]。CCL9巨噬细胞和骨髓细胞里也持续表达^[3]^[4]。编码CCL9的基因位于小鼠的11号染色体上^[4]。

参考文献

^ Zhao X, Sato A, Dela Cruz C, Linehan M, Luegering A, Kucharzik T, Shirakawa A, Marquez G, Farber J, Williams I, Iwasaki A. CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells. J Immunol. 2003, 171 (6): 2797–803. PMID 12960300.
^ Lean J, Murphy C, Fuller K, Chambers T. CCL9/MIP-1gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts. J Cell Biochem. 2002, 87 (4): 386–93. PMID 12397598. doi:10.1002/jcb.10319.
^ Youn B, Jang I, Broxmeyer H, Cooper S, Jenkins N, Gilbert D, Copeland N, Elick T, Fraser M, Kwon B. A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors. J Immunol. 1995, 155 (5): 2661–7. PMID 7650394.
^ ^4.0 ^4.1 Hara T, Bacon K, Cho L, Yoshimura A, Morikawa Y, Copeland N, Gilbert D, Jenkins N, Schall T, Miyajima A. Molecular cloning and functional characterization of a novel member of the C-C chemokine family. J Immunol. 1995, 155 (11): 5352–8. PMID 7594550.

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[1] Zhao X, Sato A, Dela Cruz C, Linehan M, Luegering A, Kucharzik T, Shirakawa A, Marquez G, Farber J, Williams I, Iwasaki A. CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells. J Immunol. 2003, 171 (6): 2797–803. PMID 12960300.

[2] Lean J, Murphy C, Fuller K, Chambers T. CCL9/MIP-1gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts. J Cell Biochem. 2002, 87 (4): 386–93. PMID 12397598. doi:10.1002/jcb.10319.

[3] Youn B, Jang I, Broxmeyer H, Cooper S, Jenkins N, Gilbert D, Copeland N, Elick T, Fraser M, Kwon B. A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors. J Immunol. 1995, 155 (5): 2661–7. PMID 7650394.

[hara-4] 4.0 ^4.1 Hara T, Bacon K, Cho L, Yoshimura A, Morikawa Y, Copeland N, Gilbert D, Jenkins N, Schall T, Miyajima A. Molecular cloning and functional characterization of a novel member of the C-C chemokine family. J Immunol. 1995, 155 (11): 5352–8. PMID 7594550.

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